6HNO
17beta-hydroxysteroid dehydrogenase 14 variant S205 - mutant H93A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004303 | molecular_function | estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006004 | biological_process | fucose metabolic process |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042355 | biological_process | L-fucose catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0047834 | molecular_function | D-threo-aldose 1-dehydrogenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue NAD A 301 |
| Chain | Residue |
| A | GLY16 |
| A | ASN89 |
| A | LEU113 |
| A | ILE139 |
| A | SER140 |
| A | SER141 |
| A | TYR154 |
| A | LYS158 |
| A | PRO184 |
| A | GLY185 |
| A | ILE187 |
| A | ARG19 |
| A | THR189 |
| A | PRO190 |
| A | LEU191 |
| A | TRP192 |
| A | HOH486 |
| A | HOH490 |
| A | HOH514 |
| A | GLY20 |
| A | ILE21 |
| A | ASP40 |
| A | LYS41 |
| A | CYS61 |
| A | ASP62 |
| A | VAL63 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SlvgaigqaqAvpYVATKGAVtAMTkALA |
| Chain | Residue | Details |
| A | SER141-ALA169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 |
| Chain | Residue | Details |
| A | TYR154 |
| Chain | Residue | Details |
| A | ARG19 | |
| A | ILE21 | |
| A | ASP40 | |
| A | ASP62 | |
| A | VAL63 | |
| A | ILE187 | |
| A | THR189 | |
| A | LEU191 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27362750, ECO:0007744|PDB:5O6O, ECO:0007744|PDB:5O6X, ECO:0007744|PDB:6QCK, ECO:0007744|PDB:6ZRA, ECO:0007744|PDB:6ZT2 |
| Chain | Residue | Details |
| A | LYS41 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0007744|PDB:5EN4, ECO:0007744|PDB:5HS6, ECO:0007744|PDB:5ICM, ECO:0007744|PDB:5JS6, ECO:0007744|PDB:5JSF, ECO:0007744|PDB:5L7T, ECO:0007744|PDB:5L7W, ECO:0007744|PDB:5L7Y, ECO:0007744|PDB:5O42, ECO:0007744|PDB:5O43, ECO:0007744|PDB:5O6O, ECO:0007744|PDB:5O6X, ECO:0007744|PDB:5O6Z, ECO:0007744|PDB:5O72, ECO:0007744|PDB:5O7C, ECO:0007744|PDB:6EMM, ECO:0007744|PDB:6FFB, ECO:0007744|PDB:6G4L, ECO:0007744|PDB:6GBT, ECO:0007744|PDB:6GTB, ECO:0007744|PDB:6GTU, ECO:0007744|PDB:6H0M, ECO:0007744|PDB:6HNO, ECO:0007744|PDB:6QCK, ECO:0007744|PDB:6ZDE, ECO:0007744|PDB:6ZDI, ECO:0007744|PDB:6ZR6, ECO:0007744|PDB:6ZRA, ECO:0007744|PDB:6ZT2 |
| Chain | Residue | Details |
| A | ASN89 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27362750, ECO:0000269|PubMed:27933965, ECO:0000269|PubMed:29859505, ECO:0000269|PubMed:30836176, ECO:0007744|PDB:5EN4, ECO:0007744|PDB:5HS6, ECO:0007744|PDB:5ICM, ECO:0007744|PDB:5JS6, ECO:0007744|PDB:5L7T, ECO:0007744|PDB:5L7W, ECO:0007744|PDB:5L7Y, ECO:0007744|PDB:5O42, ECO:0007744|PDB:5O43, ECO:0007744|PDB:5O6O, ECO:0007744|PDB:5O72, ECO:0007744|PDB:6FFB, ECO:0007744|PDB:6GTB, ECO:0007744|PDB:6H0M, ECO:0007744|PDB:6HNO, ECO:0007744|PDB:6QCK, ECO:0007744|PDB:6ZDE, ECO:0007744|PDB:6ZDI, ECO:0007744|PDB:6ZRA, ECO:0007744|PDB:6ZT2 |
| Chain | Residue | Details |
| A | TYR154 |
| Chain | Residue | Details |
| A | LYS158 |
