7AT1
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![BU of 7at1 by Molmil](/molmil-images/mine/7at1) | CRYSTAL STRUCTURES OF ASPARTATE CARBAMOYLTRANSFERASE LIGATED WITH PHOSPHONOACETAMIDE, MALONATE, AND CTP OR ATP AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ... | 著者 | Gouaux, J.E, Stevens, R.C, Lipscomb, W.N. | 登録日 | 1989-09-22 | 公開日 | 1990-10-15 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH. Biochemistry, 29, 1990
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4JTU
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![BU of 4jtu by Molmil](/molmil-images/mine/4jtu) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with brequinar analogue | 分子名称: | 6-bromo-2-{4-[(2R)-butan-2-yl]phenyl}-3-methylquinoline-4-carboxylic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Zhu, L, Zhu, J, Ren, X, Li, H. | 登録日 | 2013-03-24 | 公開日 | 2014-03-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 To be Published
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4JS3
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![BU of 4js3 by Molmil](/molmil-images/mine/4js3) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 | 分子名称: | 2-chloro-4-methyl-N-(naphthalen-2-yl)-1,3-thiazole-5-carboxamide, ACETIC ACID, Dihydroorotate dehydrogenase (quinone), ... | 著者 | Zhu, L, Li, H, Zhu, J, Ren, X. | 登録日 | 2013-03-22 | 公開日 | 2014-03-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 TO BE PUBLISHED
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4GRD
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![BU of 4grd by Molmil](/molmil-images/mine/4grd) | |
4JTS
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![BU of 4jts by Molmil](/molmil-images/mine/4jts) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 072 | 分子名称: | 4-methyl-N-(naphthalen-2-yl)-1,3-thiazole-5-carboxamide, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | 著者 | Zhu, L, Zhu, J, Ren, X, Li, H. | 登録日 | 2013-03-24 | 公開日 | 2014-03-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | 主引用文献 | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 To be Published
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7ASQ
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![BU of 7asq by Molmil](/molmil-images/mine/7asq) | |
6HV2
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![BU of 6hv2 by Molmil](/molmil-images/mine/6hv2) | MMP-13 in complex with the peptide IMISF | 分子名称: | CALCIUM ION, Collagenase 3, GLYCEROL, ... | 著者 | Mittl, P, Riedl, R, Hohl, D. | 登録日 | 2018-10-10 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.709 Å) | 主引用文献 | Drug Design Inspired by Nature: Crystallographic Detection of an Auto-Tailored Protease Inhibitor Template. Angew.Chem.Int.Ed.Engl., 58, 2019
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7CA0
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![BU of 7ca0 by Molmil](/molmil-images/mine/7ca0) | Crystal structure of dihydroorotase in complex with 5-fluoroorotic acid from Saccharomyces cerevisiae | 分子名称: | 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, Dihydroorotase, ZINC ION | 著者 | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | 登録日 | 2020-06-08 | 公開日 | 2021-06-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Complexed Crystal Structure of Saccharomyces cerevisiae Dihydroorotase with Inhibitor 5-Fluoroorotate Reveals a New Binding Mode. Bioinorg Chem Appl, 2021, 2021
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6JKT
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![BU of 6jkt by Molmil](/molmil-images/mine/6jkt) | Crystal structure of aspartate transcarbamoylase from Trypanosoma cruzi in complex with N-(PHOSPHONACETYL)-L-ASPARTIC ACID (PALA). | 分子名称: | Aspartate carbamoyltransferase, GLYCEROL, N-(PHOSPHONACETYL)-L-ASPARTIC ACID | 著者 | Matoba, K, Shiba, T, Nara, T, Aoki, T, Nagasaki, S, Hayamizu, R, Honma, T, Tanaka, A, Inoue, M, Matsuoka, S, Balogun, E.O, Inaoka, D.K, Kita, K, Harada, S. | 登録日 | 2019-03-01 | 公開日 | 2020-03-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystallographic snapshots of Trypanosoma cruzi aspartate transcarbamoylase
revealed an ordered Bi-Bi reaction mechanism To Be Published
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6JMD
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![BU of 6jmd by Molmil](/molmil-images/mine/6jmd) | Crystal structure of human DHODH in complex with inhibitor 1223 | 分子名称: | 3-[3,5-bis(fluoranyl)-4-[3-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | 著者 | Yu, Y, Chen, Q. | 登録日 | 2019-03-08 | 公開日 | 2020-03-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.781 Å) | 主引用文献 | Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production. J.Med.Chem., 63, 2020
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6JKQ
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![BU of 6jkq by Molmil](/molmil-images/mine/6jkq) | Crystal structure of aspartate transcarbamoylase from Trypanosoma cruzi (Ligand-free form) | 分子名称: | Aspartate carbamoyltransferase | 著者 | Matoba, K, Shiba, T, Nara, T, Aoki, T, Nagasaki, S, Hayamizu, R, Honma, T, Tanaka, A, Inoue, M, Matsuoka, S, Balogun, E.O, Inaoka, D.K, Kita, K, Harada, S. | 登録日 | 2019-03-01 | 公開日 | 2020-03-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Crystallographic snapshots of Trypanosoma cruzi aspartate transcarbamoylase
revealed an ordered Bi-Bi reaction mechanism To Be Published
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6JL6
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![BU of 6jl6 by Molmil](/molmil-images/mine/6jl6) | Crystal structure of aspartate transcarbamoylase from Trypanosoma cruzi in complex with phosphate (Pi). | 分子名称: | ASPARTIC ACID, Aspartate carbamoyltransferase, PHOSPHATE ION | 著者 | Matoba, K, Shiba, T, Nara, T, Aoki, T, Nagasaki, S, Hayamizu, R, Honma, T, Tanaka, A, Inoue, M, Matsuoka, S, Balogun, E.O, Inaoka, D.K, Kita, K, Harada, S. | 登録日 | 2019-03-04 | 公開日 | 2020-03-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystallographic snapshots of Trypanosoma cruzi aspartate transcarbamoylase
revealed an ordered Bi-Bi reaction mechanism To Be Published
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6L0J
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![BU of 6l0j by Molmil](/molmil-images/mine/6l0j) | Crystal structure of Dihydroorotase in complex with malate at pH7.5 from Saccharomyces cerevisiae | 分子名称: | (2S)-2-hydroxybutanedioic acid, Dihydroorotase, ZINC ION | 著者 | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | 登録日 | 2019-09-26 | 公開日 | 2020-12-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.933 Å) | 主引用文献 | Structural Analysis of Saccharomyces cerevisiae Dihydroorotase Reveals Molecular Insights into the Tetramerization Mechanism Molecules, 2021
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4LC8
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![BU of 4lc8 by Molmil](/molmil-images/mine/4lc8) | Crystal structure of the mutant H128N of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP | 分子名称: | 1,2-ETHANEDIOL, 6-HYDROXYURIDINE-5'-PHOSPHATE, CHLORIDE ION, ... | 著者 | Fedorov, A.A, Fedorov, E.V, Desai, B, Gerlt, J.A, Almo, S.C. | 登録日 | 2013-06-21 | 公開日 | 2013-07-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.318 Å) | 主引用文献 | Crystal structure of the mutant H128N of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP To be Published
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2X75
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![BU of 2x75 by Molmil](/molmil-images/mine/2x75) | Staphylococcus aureus adenylosuccinate lyase | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENYLOSUCCINATE LYASE, CHLORIDE ION, ... | 著者 | Fyfe, P.K, Dawson, A, Hutchison, M.T, Cameron, S, Hunter, W.N. | 登録日 | 2010-02-23 | 公開日 | 2010-03-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of Staphylococcus Aureus Adenylosuccinate Lyase (Purb) and Assessment of its Potential as a Target for Structure-Based Inhibitor Discovery. Acta Crystallogr.,Sect.D, 66, 2010
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5AT1
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![BU of 5at1 by Molmil](/molmil-images/mine/5at1) | STRUCTURAL CONSEQUENCES OF EFFECTOR BINDING TO THE T STATE OF ASPARTATE CARBAMOYLTRANSFERASE. CRYSTAL STRUCTURES OF THE UNLIGATED AND ATP-, AND CTP-COMPLEXED ENZYMES AT 2.6-ANGSTROMS RESOLUTION | 分子名称: | ASPARTATE CARBAMOYLTRANSFERASE (T STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ... | 著者 | Stevens, R.C, Gouaux, J.E, Lipscomb, W.N. | 登録日 | 1990-04-26 | 公開日 | 1990-10-15 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution. Biochemistry, 29, 1990
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2YYU
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![BU of 2yyu by Molmil](/molmil-images/mine/2yyu) | Crystal structure of uncharacterized conserved protein from Geobacillus kaustophilus | 分子名称: | CYTIDINE-5'-MONOPHOSPHATE, Orotidine 5'-phosphate decarboxylase | 著者 | Kanagawa, M, Baba, S, Nakamura, Y, Bessho, Y, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2007-05-02 | 公開日 | 2007-11-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of uncharacterized conserved protein from Geobacillus kaustophilus To be Published
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2J91
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![BU of 2j91 by Molmil](/molmil-images/mine/2j91) | Crystal structure of Human Adenylosuccinate Lyase in complex with AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENYLOSUCCINATE LYASE, CHLORIDE ION, ... | 著者 | Stenmark, P, Moche, M, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ericsson, U.B, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Johansson, I, Karlberg, T, Kosinska, U, Kotenyova, T, Magnusdottir, A, Nilsson, M.E, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Uppsten, M, Thorsell, A.G, van Den Berg, S, Wallden, K, Weigelt, J, Nordlund, P. | 登録日 | 2006-11-01 | 公開日 | 2006-11-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal Structure of Human Adenylosuccinate Lyase To be Published
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7ZEA
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![BU of 7zea by Molmil](/molmil-images/mine/7zea) | |
7ZCZ
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![BU of 7zcz by Molmil](/molmil-images/mine/7zcz) | |
7Z6C
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![BU of 7z6c by Molmil](/molmil-images/mine/7z6c) | Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-ispropyl-5-methyl-4-phenoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboxamide. | 分子名称: | ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Alberti, M, Lolli, M.L, Boschi, D, Sainas, S, Rizzi, M, Ferraris, D.M, Miggiano, R. | 登録日 | 2022-03-11 | 公開日 | 2022-10-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a ]pyridine Scaffold: SAR of the Aryloxyaryl Moiety. J.Med.Chem., 65, 2022
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4P3X
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![BU of 4p3x by Molmil](/molmil-images/mine/4p3x) | Structure of the Fe4S4 quinolinate synthase NadA from Thermotoga maritima | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, IRON/SULFUR CLUSTER, Quinolinate synthase A, ... | 著者 | Cherrier, M.V, Chan, A, Darnault, C, Reichmann, D, Amara, P, Ollagnier de Choudens, S, Fontecilla-Camps, J.C. | 登録日 | 2014-03-10 | 公開日 | 2014-04-02 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The crystal structure of Fe4S4 quinolinate synthase unravels an enzymatic dehydration mechanism that uses tyrosine and a hydrolase-type triad. J.Am.Chem.Soc., 136, 2014
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7JMF
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![BU of 7jmf by Molmil](/molmil-images/mine/7jmf) | Functional Pathways of Biomolecules Retrieved from Single-particle Snapshots - Frame 42 - State 6 (S6) | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ZINC ION, ... | 著者 | Dashti, A, des Georges, A, Frank, J, Ourmazd, A. | 登録日 | 2020-07-31 | 公開日 | 2020-08-12 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Retrieving functional pathways of biomolecules from single-particle snapshots. Nat Commun, 11, 2020
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3M47
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![BU of 3m47 by Molmil](/molmil-images/mine/3m47) | Crystal structure of the mutant I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum | 分子名称: | GLYCEROL, Orotidine 5'-phosphate decarboxylase | 著者 | Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. | 登録日 | 2010-03-10 | 公開日 | 2010-06-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
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3NQ6
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![BU of 3nq6 by Molmil](/molmil-images/mine/3nq6) | Crystal structure of the mutant P180A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor 6-azaUMP | 分子名称: | 6-AZA URIDINE 5'-MONOPHOSPHATE, GLYCEROL, Orotidine 5'-phosphate decarboxylase | 著者 | Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. | 登録日 | 2010-06-29 | 公開日 | 2011-05-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.494 Å) | 主引用文献 | Crystal structure of the mutant P180A of orotidine 5'-monophosphate
decarboxylase from Methanobacterium thermoautotrophicum complexed with
inhibitor 6-azaUMP To be Published
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