8CAU
| human alpha7 nicotinic receptor in complex with the C4 nanobody and nicotine | 分子名称: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Prevost, M.S, Barilone, N, Dejean de la Batie, G, Pons, S, Ayme, G, England, P, Gielen, M, Bontems, F, Pehau-Arnaudet, G, Maskos, U, Lafaye, P, Corringer, P.-J. | 登録日 | 2023-01-24 | 公開日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies. Nat Commun, 14, 2023
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8CC6
| Mouse serotonin 5-HT3A receptor in complex with PZ-1922 | 分子名称: | 1-[(3-chlorophenyl)methyl]-4-piperazin-1-yl-pyrrolo[3,2-c]quinoline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lopez-Sanchez, U, Nury, H. | 登録日 | 2023-01-26 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Superiority of the Triple-Acting 5-HT 6 R/5-HT 3 R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT 6 R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats. J.Med.Chem., 66, 2023
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8CC7
| Mouse serotonin 5-HT3A receptor in complex with PZ-1939 | 分子名称: | 1-(3-chlorophenyl)sulfonyl-4-piperazin-1-yl-pyrrolo[3,2-c]quinoline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lopez-Sanchez, U, Nury, H. | 登録日 | 2023-01-26 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Superiority of the Triple-Acting 5-HT 6 R/5-HT 3 R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT 6 R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats. J.Med.Chem., 66, 2023
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8CE4
| Human alpha7 nicotinic receptor in complex with the E3 nanobody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody E3, ... | 著者 | Prevost, M.S, Barilone, N, Dejean de la Batie, G, Pons, S, Ayme, G, England, P, Gielen, M, Bontems, F, Pehau-Arnaudet, G, Maskos, U, Lafaye, P, Corringer, P.-J. | 登録日 | 2023-02-01 | 公開日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies. Nat Commun, 14, 2023
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8CI1
| Human alpha7 nicotinic receptor in complex with the E3 nanobody and nicotine | 分子名称: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Prevost, M.S, Barilone, N, Dejean de la Batie, G, Pons, S, Ayme, G, England, P, Gielen, M, Bontems, F, Pehau-Arnaudet, G, Maskos, U, Lafaye, P, Corringer, P.-J. | 登録日 | 2023-02-08 | 公開日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies. Nat Commun, 14, 2023
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8CI2
| human alpha7 nicotinic receptor in complex with the C4 nanobody under sub-saturating conditions | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody C4, ... | 著者 | Prevost, M.S, Barilone, N, Dejean de la Batie, G, Pons, S, Ayme, G, England, P, Gielen, M, Bontems, F, Pehau-Arnaudet, G, Maskos, U, Lafaye, P, Corringer, P.-J. | 登録日 | 2023-02-08 | 公開日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies. Nat Commun, 14, 2023
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8DD2
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8DD3
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8DN2
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8DN3
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8DN4
| Cryo-EM structure of human Glycine Receptor alpha-1 beta heteromer, glycine-bound state3(desensitized state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alpha-1, Glycine receptor subunit beta,Green fluorescent protein,Glycine receptor beta, ... | 著者 | Liu, X, Wang, W. | 登録日 | 2022-07-10 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Asymmetric gating of a human hetero-pentameric glycine receptor. Nat Commun, 14, 2023
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8DN5
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8EIS
| Cryo-EM structure of octopus sensory receptor CRT1 | 分子名称: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Octopus sensory receptor | 著者 | Kang, G, Kim, J.J, Allard, C.A.H, Valencia-Montoya, W.A, Bellono, N.W, Hibbs, R.E. | 登録日 | 2022-09-15 | 公開日 | 2023-04-12 | 最終更新日 | 2023-04-26 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | Sensory specializations drive octopus and squid behaviour. Nature, 616, 2023
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8ESK
| Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium, resting-like state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | 登録日 | 2022-10-14 | 公開日 | 2023-06-07 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
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8F2S
| Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium, pore-blocked state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | 登録日 | 2022-11-08 | 公開日 | 2023-06-07 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
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8F4V
| Alpha7 nicotinic acetylcholine receptor intracellular and transmembrane domains bound to ivermectin in a desensitized state | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, Neuronal acetylcholine receptor subunit alpha-7 | 著者 | Bondarenko, V, Chen, Q, Tang, P. | 登録日 | 2022-11-11 | 公開日 | 2023-02-22 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Elucidation of Ivermectin Binding to alpha 7nAChR and the Induced Channel Desensitization. Acs Chem Neurosci, 14, 2023
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8F6Y
| Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with etomidate, desensitized-like state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | 登録日 | 2022-11-17 | 公開日 | 2023-06-07 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
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8F6Z
| Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with succinylcholine, desensitized-like state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM), 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | 登録日 | 2022-11-17 | 公開日 | 2023-06-07 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
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8FE1
| Alpha1/BetaB Heteromeric Glycine Receptor in 1 mM Glycine 20 uM Ivermectin State | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gibbs, E, Chakrapani, S. | 登録日 | 2022-12-05 | 公開日 | 2023-03-22 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | High-throughput reprogramming of an NRPS condensation domain. Nat.Chem.Biol., 2024
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8FOI
| Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA and allopregnanolone | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, DODECANE, ... | 著者 | Sun, C, Gouaux, E. | 登録日 | 2022-12-30 | 公開日 | 2023-09-20 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology. Nature, 622, 2023
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8FRW
| Full-length mouse 5-HT3A receptor in complex with ALB148471, pre-activated | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[(1R,3S,5R)-1-azabicyclo[3.2.2]nonan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one, 5-hydroxytryptamine receptor 3A | 著者 | Felt, K.C, Chakrapani, S. | 登録日 | 2023-01-09 | 公開日 | 2023-12-27 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Structural basis for partial agonism in 5-HT 3A receptors. Nat.Struct.Mol.Biol., 31, 2024
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8FRX
| Full-length mouse 5-HT3A receptor in complex with SMP100, pre-activated | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[(1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one, 5-hydroxytryptamine receptor 3A | 著者 | Felt, K.C, Chakrapani, S. | 登録日 | 2023-01-09 | 公開日 | 2023-12-27 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural basis for partial agonism in 5-HT 3A receptors. Nat.Struct.Mol.Biol., 31, 2024
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8FRZ
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8FSB
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8FSP
| Full-length mouse 5-HT3A receptor in complex with SMP100, open-like | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[(1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one, 5-hydroxytryptamine receptor 3A | 著者 | Felt, K.C, Chakrapani, S. | 登録日 | 2023-01-10 | 公開日 | 2023-12-27 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.79 Å) | 主引用文献 | Structural basis for partial agonism in 5-HT 3A receptors. Nat.Struct.Mol.Biol., 31, 2024
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