8J86
 
 | | Monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex in a DNA binding form | | 分子名称: | CALCIUM ION, DNA (5'-D(P*AP*GP*CP*TP*GP*CP*TP*AP*TP*GP*TP*GP*AP*GP*AP*TP*TP*AP*AP*GP*TP*TP*AP*T)-3'), DNA (5'-D(P*GP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*GP*AP*TP*AP*AP*CP*TP*TP*AP*AP*TP*CP*TP*CP*AP*CP*AP*TP*AP*GP*CP*AP*GP*CP*TP*)-3'), ... | | 著者 | Xu, Y, Wu, Y, Wu, X, Zhang, Y, Yang, Y, Li, D, Yang, B, Gao, K, Zhang, Z, Dong, C. | | 登録日 | 2023-04-30 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir.
Int.J.Biol.Macromol., 270, 2024
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8J8F
 | | Monkeypox virus DNA replication holoenzyme F8, A22 and E4 in complex with a DNA duplex and dCTP | | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*AP*GP*CP*TP*GP*CP*TP*AP*TP*GP*AP*GP*AP*TP*TP*AP*AP*GP*TP*TP*AP*T)-3'), ... | | 著者 | Xu, Y, Wu, Y, Wu, X, Zhang, Y, Yang, Y, Li, D, Yang, B, Gao, K, Zhang, Z, Dong, C. | | 登録日 | 2023-05-01 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir.
Int.J.Biol.Macromol., 270, 2024
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8J8G
 | | Monkeypox virus DNA replication holoenzyme F8, A22 and E4 in complex with a DNA duplex and cidofovir diphosphate | | 分子名称: | CALCIUM ION, DNA (5'-D(P*AP*GP*CP*TP*GP*CP*TP*AP*TP*GP*AP*GP*AP*TP*TP*AP*AP*GP*TP*TP*AP*T)-3'), DNA (5'-D(P*GP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*GP*AP*TP*AP*AP*CP*TP*TP*AP*AP*TP*CP*TP*CP*AP*CP*AP*TP*AP*GP*CP*AP*GP*CP*T)-3'), ... | | 著者 | Xu, Y, Wu, Y, Wu, X, Zhang, Y, Yang, Y, Li, D, Yang, B, Gao, K, Zhang, Z, Dong, C. | | 登録日 | 2023-05-01 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | | 主引用文献 | Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir.
Int.J.Biol.Macromol., 270, 2024
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8TLT
 | | Cryo-EM structure of Rev1(deltaN)-Polzeta-DNA-dCTP complex | | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*TP*AP*AP*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*AP*AP*T)-3'), ... | | 著者 | Malik, R, Aggarwal, A.K. | | 登録日 | 2023-07-27 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Cryo-EM structure of the Rev1-Pol zeta holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis.
Nat.Struct.Mol.Biol., 31, 2024
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8TLQ
 | | Cryo-EM structure of the Rev1-Polzeta-DNA-dCTP complex | | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ... | | 著者 | Malik, R, Aggarwal, A.K. | | 登録日 | 2023-07-27 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | | 主引用文献 | Cryo-EM structure of the Rev1-Pol zeta holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis.
Nat.Struct.Mol.Biol., 31, 2024
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8UCU
 | | Partial DNA termination subcomplex of Xenopus laevis DNA polymerase alpha-primase | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA template, ... | | 著者 | Mullins, E.A, Chazin, W.J, Eichman, B.F. | | 登録日 | 2023-09-27 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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8UCV
 | | Complete DNA termination subcomplex 1 of Xenopus laevis DNA polymerase alpha-primase | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA primase large subunit, ... | | 著者 | Mullins, E.A, Chazin, W.C, Eichman, B.F. | | 登録日 | 2023-09-27 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | | 主引用文献 | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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8UCW
 | | Complete DNA termination subcomplex 2 of Xenopus laevis DNA polymerase alpha-primase | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA template, ... | | 著者 | Mullins, E.A, Chazin, W.C, Eichman, B.F. | | 登録日 | 2023-09-27 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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8V5M
 | | Tetramer core subcomplex (conformation 1) of Xenopus laevis DNA polymerase alpha-primase | | 分子名称: | DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ... | | 著者 | Mullins, E.A, Chazin, W.J, Eichman, B.F. | | 登録日 | 2023-11-30 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (9.22 Å) | | 主引用文献 | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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8V6J
 | | DNA elongation complex (configuration 2) of Xenopus laevis DNA polymerase alpha-primase | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, ... | | 著者 | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | | 登録日 | 2023-12-01 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (11.11 Å) | | 主引用文献 | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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8V5O
 | | Tetramer core subcomplex (conformation 3) of Xenopus laevis DNA polymerase alpha-primase | | 分子名称: | DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ... | | 著者 | Mullins, E.A, Chazin, W.J, Eichman, B.F. | | 登録日 | 2023-11-30 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (8.99 Å) | | 主引用文献 | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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8V5N
 | | Tetramer core subcomplex (conformation 2) of Xenopus laevis DNA polymerase alpha-primase | | 分子名称: | DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ... | | 著者 | Mullins, E.A, Chazin, W.J, Eichman, B.F. | | 登録日 | 2023-11-30 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (8.56 Å) | | 主引用文献 | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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8V6I
 | | DNA elongation complex (configuration 1) of Xenopus laevis DNA polymerase alpha-primase | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, ... | | 著者 | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | | 登録日 | 2023-12-01 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (14.06 Å) | | 主引用文献 | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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8V6G
 | | DNA initiation complex (configuration 1) of Xenopus laevis DNA polymerase alpha-primase | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, ... | | 著者 | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | | 登録日 | 2023-12-01 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (11.16 Å) | | 主引用文献 | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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8V6H
 | | DNA initiation complex (configuration 2) of Xenopus laevis DNA polymerase alpha-primase | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, ... | | 著者 | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | | 登録日 | 2023-12-01 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (11.11 Å) | | 主引用文献 | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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8K8S
 | | F8-A22-E4 complex of MPXV in complex with DNA and Ara-CTP | | 分子名称: | 4-amino-1-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}pyrimidin-2(1H)-one, DNA (5'-D(*AP*TP*CP*CP*TP*CP*CP*CP*CP*TP*AP*C)-3'), DNA (5'-D(P*TP*AP*GP*GP*TP*AP*GP*GP*GP*GP*AP*GP*GP*AP*T)-3'), ... | | 著者 | Shen, Y.P, Li, Y.N, Yan, R.H. | | 登録日 | 2023-07-31 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Structural basis for the inhibition mechanism of the DNA polymerase holoenzyme from mpox virus.
Structure, 32, 2024
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8K8U
 | | F8-A22-E4 complex of MPXV in complex with DNA and dCTP | | 分子名称: | CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*CP*CP*TP*CP*CP*CP*CP*TP*AP*C)-3'), DNA (5'-D(P*AP*AP*GP*GP*TP*AP*GP*GP*GP*GP*AP*GP*GP*AP*T)-3'), ... | | 著者 | Shen, Y.P, Li, Y.N, Yan, R.H. | | 登録日 | 2023-07-31 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Structural basis for the inhibition mechanism of the DNA polymerase holoenzyme from mpox virus.
Structure, 32, 2024
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8OJ6
 | | HSV-1 DNA polymerase-processivity factor complex in pre-translocation state | | 分子名称: | DNA (22-MER), DNA (48-MER), DNA polymerase catalytic subunit, ... | | 著者 | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | 登録日 | 2023-03-24 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | | 主引用文献 | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 52, 2024
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8OJD
 | | HSV-1 DNA polymerase beta-hairpin loop | | 分子名称: | CALCIUM ION, DNA (47-MER), DNA (68-MER), ... | | 著者 | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | 登録日 | 2023-03-24 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.46 Å) | | 主引用文献 | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 52, 2024
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8OJ7
 | | HSV-1 DNA polymerase-processivity factor complex in halted elongation state | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (53-MER), DNA (67-MER), ... | | 著者 | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | 登録日 | 2023-03-24 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.46 Å) | | 主引用文献 | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 52, 2024
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8OJB
 | | HSV-1 DNA polymerase-processivity factor complex in exonuclease state active site | | 分子名称: | CALCIUM ION, DNA (47-MER), DNA polymerase catalytic subunit | | 著者 | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | 登録日 | 2023-03-24 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | | 主引用文献 | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 52, 2024
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8OJC
 | | HSV-1 DNA polymerase active site in alternative exonuclease state | | 分子名称: | CALCIUM ION, DNA (47-MER), DNA polymerase catalytic subunit | | 著者 | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | 登録日 | 2023-03-24 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.08 Å) | | 主引用文献 | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 52, 2024
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8OJA
 | | HSV-1 DNA polymerase-processivity factor complex in exonuclease state | | 分子名称: | CALCIUM ION, DNA (47-MER), DNA (68-MER), ... | | 著者 | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | 登録日 | 2023-03-24 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (1.87 Å) | | 主引用文献 | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 52, 2024
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8Q3R
 | | Cryo-EM structure of the DNA polymerase holoenzyme E9-A20-D4 of vaccinia virus | | 分子名称: | DNA polymerase, DNA polymerase processivity factor component OPG148, Uracil-DNA glycosylase | | 著者 | Burmeister, W.P, Ballandras-Colas, A, Boettcher, B, Grimm, C. | | 登録日 | 2023-08-04 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure and flexibility of the DNA polymerase holoenzyme of vaccinia virus.
Plos Pathog., 20, 2024
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4B08
 | | Yeast DNA polymerase alpha, Selenomethionine protein | | 分子名称: | DNA POLYMERASE ALPHA CATALYTIC SUBUNIT A | | 著者 | Perera, R.L, Torella, R, Klinge, S, Kilkenny, M.L, Maman, J.D, Pellegrini, L. | | 登録日 | 2012-06-29 | | 公開日 | 2013-02-27 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Mechanism for Priming DNA Synthesis by Yeast DNA Polymerase Alpha
Elife, 2, 2013
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