PDB: 496 件ウェブページステータス検索Chemie searchBIRD

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8G6O	HIV-1 capsid lattice bound to IP6 and Lenacapavir 分子名称: Capsid protein 著者 Highland, C.M, Dick, R.A. 登録日 2023-02-15 公開日 2023-05-03 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into HIV-1 polyanion-dependent capsid lattice formation revealed by single particle cryo-EM. Proc.Natl.Acad.Sci.USA, 120, 2023
3MBL	Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP 分子名称: 5-acetyl-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrole-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Dougan, D.R, Mol, C.D. 登録日 2010-03-25 公開日 2010-07-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
3M93	Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, Translation initiation factor 4E 著者 Liu, W, Berkeley Structural Genomics Center (BSGC) 登録日 2010-03-19 公開日 2011-07-20 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation. Nucleic Acids Res., 39, 2011
3MGE	X-ray Structure of Hexameric HIV-1 CA 分子名称: 1,2-ETHANEDIOL, Capsid protein p24 著者 Pornillos, O. 登録日 2010-04-05 公開日 2010-07-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Disulfide Bond Stabilization of the Hexameric Capsomer of Human Immunodeficiency Virus. J.Mol.Biol., 401, 2010
6OPI	phosphorylated ERK2 with SCH-CPD336 分子名称: (3R)-N-[3-(2-cyclopropylpyridin-4-yl)-1H-indazol-5-yl]-3-(methoxymethyl)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}ethyl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1 著者 Vigers, G.P, Smith, D. 登録日 2019-04-25 公開日 2019-07-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2. Proc.Natl.Acad.Sci.USA, 116, 2019
3R63	Structure of ERK2 (SPE) mutant (S246E) 分子名称: Mitogen-activated protein kinase 1 著者 Livnah, O, Karamansha, Y. 登録日 2011-03-21 公開日 2011-08-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Nuclear ERK translocation is mediated by protein kinase CK2 and accelerated by autophosphorylation. Mol.Cell.Biol., 31, 2011
3R90	Crystal structure of Malignant T cell-amplified sequence 1 protein 分子名称: GLYCEROL, Malignant T cell-amplified sequence 1, SULFATE ION, ... 著者 Hong, B, Dimov, S, Tempel, W, Tong, Y, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) 登録日 2011-03-24 公開日 2011-04-13 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of Malignant T cell-amplified sequence 1 protein to be published
6OBH	Structure of HIV-1 CA 1/2-hexamer 分子名称: CA, SODIUM ION 著者 Summers, B.J, Xiong, Y. 登録日 2019-03-20 公開日 2019-08-28 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.96 Å) 主引用文献 Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms. Cell Host Microbe, 26, 2019
5HD4	Dissecting Therapeutic Resistance to ERK Inhibition Rat Wild Type SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide 分子名称: (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 Jha, S, Morris, E.J, Hruza, A, Mansueto, M.S, Schroeder, G, Arbanas, J, McMasters, D, Restaino, C.R, Dayananth, R, Black, S, Elsen, N.L, Mannarino, A, Cooper, A, Fawell, S, Zawel, L, Jayaraman, L, Samatar, A.A. 登録日 2016-01-04 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Dissecting Therapeutic Resistance to ERK Inhibition. Mol.Cancer Ther., 15, 2016
5HGO	Hexameric HIV-1 CA R18G mutant 分子名称: Capsid protein P24 著者 Jacques, D.A, James, L.C. 登録日 2016-01-08 公開日 2016-08-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis. Nature, 536, 2016
3I5Z	Crystal structure of ERK2 bound to (S)-N-(2-hydroxy-1-phenylethyl)-4-(5-methyl-2-(phenylamino)pyrimidin-4-yl)-1H-pyrrole-2-carboxamide 分子名称: Mitogen-activated protein kinase 1, N-[(1S)-2-hydroxy-1-phenylethyl]-4-[5-methyl-2-(phenylamino)pyrimidin-4-yl]-1H-pyrrole-2-carboxamide, SULFATE ION 著者 Jacobs, M.D, Xie, X. 登録日 2009-07-06 公開日 2010-01-12 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J.Med.Chem., 52, 2009
6OPH	phosphorylated ERK2 with GDC-0994 分子名称: 1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one, Mitogen-activated protein kinase 1 著者 Vigers, G.P, Smith, D. 登録日 2019-04-25 公開日 2019-07-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2. Proc.Natl.Acad.Sci.USA, 116, 2019
3HXI	Crystal structure of Schistosome eIF4E complexed with m7GpppG and 4E-BP 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Eukaryotic Translation Initiation 4E, Eukaryotic translation initiation factor 4E-binding protein 1 著者 Liu, W, Zhao, R, Jones, D.N.M, Davis, R.E. 登録日 2009-06-20 公開日 2009-08-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural insights into parasite EIF4E binding specificity for m7G and m2,2,7G mRNA cap. J.Biol.Chem., 284, 2009
5IRT	Dimerization interface of the noncrystalline HIV-1 capsid protein lattice from solid state NMR spectroscopy of tubular assemblies 分子名称: Capsid protein p24 著者 Bayro, M.J, Tycko, R. 登録日 2016-03-14 公開日 2016-06-22 最終更新日 2024-05-15 実験手法 SOLID-STATE NMR 主引用文献 Structure of the Dimerization Interface in the Mature HIV-1 Capsid Protein Lattice from Solid State NMR of Tubular Assemblies. J.Am.Chem.Soc., 138, 2016
5HD7	Dissecting Therapeutic Resistance to ERK Inhibition Rat Mutant SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide 分子名称: (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 Jha, S, Morris, E.J, Hruza, A, Mansueto, M.S, Schroeder, G, Arbanas, J, McMasters, D, Restaino, C.R, Dayananth, R, Black, S, Elsen, N.L, Mannarino, A, Cooper, A, Fawell, S, Zawel, L, Jayaraman, L, Samatar, A.A. 登録日 2016-01-04 公開日 2016-02-24 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Dissecting Therapeutic Resistance to ERK Inhibition. Mol.Cancer Ther., 15, 2016
5HGM	Hexameric HIV-1 CA in complex with dATP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Capsid protein P24 著者 Jacques, D.A, James, L.C. 登録日 2016-01-08 公開日 2016-08-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis. Nature, 536, 2016
3ORN	Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP 分子名称: 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(3-oxo-1,2-oxazinan-2-yl)methyl]benzamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Lukacs, C.M, Janson, C, Schuck, V, Belunis, C. 登録日 2010-09-07 公開日 2011-03-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent. Bioorg.Med.Chem.Lett., 21, 2011
3OS3	Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4858061 and MgATP 分子名称: 2-[(4-ethynyl-2-fluorophenyl)amino]-3,4-difluoro-N-(2-hydroxyethoxy)-5-{[(2-hydroxyethoxy)imino]methyl}benzamide, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Lukacs, C.M, Janson, C, Schuck, V, Belunis, C. 登録日 2010-09-08 公開日 2011-07-27 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent. Bioorg.Med.Chem.Lett., 21, 2011
3SA0	Complex of ERK2 with norathyriol 分子名称: Mitogen-activated protein kinase 1, SULFATE ION, norathyriol 著者 Kurinov, I, Malakhova, M. 登録日 2011-06-02 公開日 2011-12-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.5947 Å) 主引用文献 Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases. Cancer Res., 72, 2012
3SLS	Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP 分子名称: 2-[(2-fluoro-4-iodophenyl)amino]-5,5-dimethyl-8-oxo-N-[(3R)-piperidin-3-yl]-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine-3-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Meier, C, Ceska, T.A. 登録日 2011-06-25 公開日 2012-02-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting. J.Struct.Biol., 177, 2012
3I60	Crystal structure of ERK2 bound to (S)-4-(2-(2-chlorophenylamino)-5-methylpyrimidin-4-yl)-N-(2-hydroxy-1-phenylethyl)-1H-pyrrole-2-carboxamide 分子名称: 4-{2-[(2-chlorophenyl)amino]-5-methylpyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-phenylethyl]-1H-pyrrole-2-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 Jacobs, M.D, Xie, X. 登録日 2009-07-06 公開日 2010-01-12 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J.Med.Chem., 52, 2009
3HXG	Crystal structure of Schistsome eIF4E complexed with m7GpppA and 4E-BP 分子名称: Eukaryotic Translation Initiation Factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE 著者 Liu, W, Zhao, R, Jones, D.N.M, Davis, R.E. 登録日 2009-06-20 公開日 2009-08-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural insights into parasite EIF4E binding specificity for m7G and m2,2,7G mRNA cap. J.Biol.Chem., 284, 2009
3P0A	X-ray structure of pentameric HIV-1 CA 分子名称: HIV-1 CA 著者 Pornillos, O. 登録日 2010-09-27 公開日 2011-01-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (5.954 Å) 主引用文献 Atomic-level modelling of the HIV capsid. Nature, 469, 2011
3P05	X-ray structure of pentameric HIV-1 CA 分子名称: HIV-1 CA, IODIDE ION 著者 Pornillos, O. 登録日 2010-09-27 公開日 2011-01-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Atomic-level modelling of the HIV capsid. Nature, 469, 2011
3TEI	Crystal structure of human ERK2 complexed with a MAPK docking peptide 分子名称: Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1 著者 Gogl, G, Remenyi, A. 登録日 2011-08-15 公開日 2012-08-15 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.404 Å) 主引用文献 Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove. Sci.Signal., 5, 2012

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