3ZM4

Crystal structure of MEK1 in complex with fragment 1

Summary for 3ZM4

Entry DOI	10.2210/pdb3zm4/pdb
Related	3ZLS 3ZLW 3ZLX 3ZLY
Descriptor	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, 7-chloranyl-6-[(3S)-pyrrolidin-3-yl]oxy-2H-isoquinolin-1-one (3 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	39181.59
Authors	Amaning, K.,Lowinsky, M.,Vallee, F.,Steier, V.,Marcireau, C.,Ugolini, A.,Delorme, C.,McCort, G.,Andouche, C.,Vougier, S.,Llopart, S.,Halland, N.,Rak, A. (deposition date: 2013-02-05, release date: 2013-05-22, Last modification date: 2019-04-24)
Primary citation	Amaning, K.,Lowinski, M.,Vallee, F.,Steier, V.,Marcireau, C.,Ugolini, A.,Delorme, C.,Foucalt, F.,Mccort, G.,Derimay, N.,Andouche, C.,Vougier, S.,Llopart, S.,Halland, N.,Rak, A. The Use of Virtual Screening and Differential Scanning Fluorimetry for the Rapid Identification of Fragments Active Against Mek1. Bioorg.Med.Chem.Lett., 23:3620-, 2013 Cited by PubMed: 23648182 DOI: 10.1016/J.BMCL.2013.04.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation