5M89
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![BU of 5m89 by Molmil](/molmil-images/mine/5m89) | Spliceosome component | 分子名称: | Spliceosome WD40 Sc | 著者 | Moura, T.R, Pena, V. | 登録日 | 2016-10-28 | 公開日 | 2018-03-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.605 Å) | 主引用文献 | Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors. Mol. Cell, 69, 2018
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1XK5
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![BU of 1xk5 by Molmil](/molmil-images/mine/1xk5) | Crystal structure of the m3G-cap-binding domain of snurportin1 in complex with a m3GpppG-cap dinucleotide | 分子名称: | 2,2,7-TRIMETHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, snurportin-1 | 著者 | Strasser, A, Dickmanns, A, Luehrmann, R, Ficner, R. | 登録日 | 2004-09-27 | 公開日 | 2005-06-07 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for m(3)G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1 Embo J., 24, 2005
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4LK2
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![BU of 4lk2 by Molmil](/molmil-images/mine/4lk2) | Crystal structure of RNA splicing effector Prp5 | 分子名称: | NICKEL (II) ION, Pre-mRNA-processing ATP-dependent RNA helicase PRP5 | 著者 | Zhang, Z.-M, Li, J, Yang, F, Xu, Y, Zhou, J. | 登録日 | 2013-07-05 | 公開日 | 2013-12-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly. Cell Rep, 5, 2013
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8BCH
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6N3D
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![BU of 6n3d by Molmil](/molmil-images/mine/6n3d) | Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State) | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Loerch, S, Jenkins, J.L, Kielkopf, C.L. | 登録日 | 2018-11-15 | 公開日 | 2019-01-02 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | 主引用文献 | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
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6N3F
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![BU of 6n3f by Molmil](/molmil-images/mine/6n3f) | Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5 | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, HIV Tat-specific factor 1, ... | 著者 | Leach, J.R, Jenkins, J.L, Kielkopf, C.L. | 登録日 | 2018-11-15 | 公開日 | 2019-01-02 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | 主引用文献 | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
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4LJY
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![BU of 4ljy by Molmil](/molmil-images/mine/4ljy) | Crystal structure of RNA splicing effector Prp5 in complex with ADP | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Zhang, Z.-M, Li, J, Yang, F, Xu, Y, Zhou, J. | 登録日 | 2013-07-05 | 公開日 | 2013-12-11 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly. Cell Rep, 5, 2013
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7OQE
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![BU of 7oqe by Molmil](/molmil-images/mine/7oqe) | Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A), Cold sensitive U2 snRNA suppressor 1, ... | 著者 | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | 登録日 | 2021-06-03 | 公開日 | 2021-08-11 | 最終更新日 | 2021-09-29 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
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7OQB
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![BU of 7oqb by Molmil](/molmil-images/mine/7oqb) | The U2 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | 分子名称: | ACT1 pre-mRNA (delta-BS-A), Cold sensitive U2 snRNA suppressor 1, Pre-mRNA-processing ATP-dependent RNA helicase PRP5, ... | 著者 | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | 登録日 | 2021-06-03 | 公開日 | 2021-08-11 | 最終更新日 | 2021-09-22 | 実験手法 | ELECTRON MICROSCOPY (9 Å) | 主引用文献 | Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
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7OQC
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![BU of 7oqc by Molmil](/molmil-images/mine/7oqc) | The U1 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A), Pre-mRNA-processing factor 39, ... | 著者 | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | 登録日 | 2021-06-03 | 公開日 | 2021-08-11 | 最終更新日 | 2021-09-29 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
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6N7P
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![BU of 6n7p by Molmil](/molmil-images/mine/6n7p) | S. cerevisiae spliceosomal E complex (UBC4) | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, Nuclear cap-binding protein complex subunit 1, Nuclear cap-binding protein subunit 2, ... | 著者 | Liu, S, Li, X, Zhou, Z.H, Zhao, R. | 登録日 | 2018-11-27 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | A unified mechanism for intron and exon definition and back-splicing. Nature, 573, 2019
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6N7R
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![BU of 6n7r by Molmil](/molmil-images/mine/6n7r) | Saccharomyces cerevisiae spliceosomal E complex (ACT1) | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA, Pre-mRNA-processing factor 39, ... | 著者 | Liu, S, Li, X, Zhou, Z.H, Zhao, R. | 登録日 | 2018-11-28 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | A unified mechanism for intron and exon definition and back-splicing. Nature, 573, 2019
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5GAP
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![BU of 5gap by Molmil](/molmil-images/mine/5gap) | Body region of the U4/U6.U5 tri-snRNP | 分子名称: | 13 kDa ribonucleoprotein-associated protein, Pre-mRNA-processing factor 31, Pre-mRNA-splicing factor 6, ... | 著者 | Nguyen, T.H.D, Galej, W.P, Oubridge, C, Bai, X.C, Newman, A, Scheres, S, Nagai, K. | 登録日 | 2015-12-15 | 公開日 | 2016-01-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution. Nature, 530, 2016
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1SYX
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![BU of 1syx by Molmil](/molmil-images/mine/1syx) | The crystal structure of a binary U5 snRNP complex | 分子名称: | CD2 antigen cytoplasmic tail-binding protein 2, Spliceosomal U5 snRNP-specific 15 kDa protein | 著者 | Nielsen, T.K, Liu, S, Luhrmann, R, Ficner, R. | 登録日 | 2004-04-02 | 公開日 | 2005-10-18 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.345 Å) | 主引用文献 | Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2). J.Mol.Biol., 369, 2007
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7PJH
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![BU of 7pjh by Molmil](/molmil-images/mine/7pjh) | Crystal structure of the human spliceosomal maturation factor AAR2 bound to the RNAse H domain of PRPF8 | 分子名称: | Pre-mRNA-processing-splicing factor 8, Protein AAR2 homolog | 著者 | Preussner, M, Santos, K, Heroven, A.C, Alles, J, Heyd, F, Wahl, M.C, Weber, G. | 登録日 | 2021-08-24 | 公開日 | 2022-11-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H-like domain of PRPF8. Acta Crystallogr D Struct Biol, 78, 2022
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3IM1
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5M52
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![BU of 5m52 by Molmil](/molmil-images/mine/5m52) | Crystal structure of yeast Brr2 full-lenght in complex with Prp8 Jab1 domain | 分子名称: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2 | 著者 | Wollenhaupt, J, Absmeier, E, Becke, C, Santos, K.F, Wahl, M.C. | 登録日 | 2016-10-20 | 公開日 | 2016-12-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2. Cell Cycle, 16, 2017
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3IM2
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7EVN
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![BU of 7evn by Molmil](/molmil-images/mine/7evn) | The cryo-EM structure of the DDX42-SF3b complex | 分子名称: | ATP-dependent RNA helicase DDX42, PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, ... | 著者 | Zhang, X, Zhan, X, Shi, Y. | 登録日 | 2021-05-21 | 公開日 | 2022-08-03 | 最終更新日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural insights into branch site proofreading by human spliceosome Nat.Struct.Mol.Biol., 2024
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5M59
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![BU of 5m59 by Molmil](/molmil-images/mine/5m59) | Crystal structure of Chaetomium thermophilum Brr2 helicase core in complex with Prp8 Jab1 domain | 分子名称: | ACETATE ION, Pre-mRNA splicing helicase-like protein, Putative pre-mRNA splicing factor | 著者 | Absmeier, E, Becke, C, Wollenhaupt, J, Santos, K.F, Wahl, M.C. | 登録日 | 2016-10-20 | 公開日 | 2016-12-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2. Cell Cycle, 16, 2017
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7P08
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7Q4A
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![BU of 7q4a by Molmil](/molmil-images/mine/7q4a) | Toxoplasma gondii PRP4K kinase domain (L715F) bound to altiratinib | 分子名称: | Altiratinib, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Swale, C, Bellini, V, Bowler, M. | 登録日 | 2021-10-29 | 公開日 | 2022-08-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase. Sci Transl Med, 14, 2022
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7P0V
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![BU of 7p0v by Molmil](/molmil-images/mine/7p0v) | Crystal structure of human SF3A1 ubiquitin-like domain in complex with U1 snRNA stem-loop 4 | 分子名称: | Isoform 2 of Splicing factor 3A subunit 1, PENTAETHYLENE GLYCOL, RNA (5'-R(P*GP*GP*GP*GP*AP*CP*UP*GP*CP*GP*UP*UP*CP*GP*CP*GP*CP*UP*UP*UP*CP*CP*CP*C)-3'), ... | 著者 | Sabath, K, de Vries, T, Jonas, S. | 登録日 | 2021-06-30 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly. Proc.Natl.Acad.Sci.USA, 119, 2022
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1URN
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![BU of 1urn by Molmil](/molmil-images/mine/1urn) | U1A MUTANT/RNA COMPLEX + GLYCEROL | 分子名称: | CHLORIDE ION, GLYCEROL, PROTEIN (U1A), ... | 著者 | Oubridge, C, Ito, N, Evans, P.R, Teo, C.-H, Nagai, K. | 登録日 | 1995-01-04 | 公開日 | 1996-03-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. Nature, 372, 1994
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2XEB
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![BU of 2xeb by Molmil](/molmil-images/mine/2xeb) | NMR STRUCTURE OF THE PROTEIN-UNBOUND SPLICEOSOMAL U4 SNRNA 5' STEM LOOP | 分子名称: | 5'-R(P*GP*AP*UP*CP*GP*UP*AP*GP*CP*CP*AP*AP*UP*GP*AP* GP*GP*UP*U)-3', 5'-R(P*GP*CP*CP*GP*AP*GP*GP*CP*GP*CP*GP*AP*UP*C)-3' | 著者 | Falb, M, Amata, I, Gabel, F, Simon, B, Carlomagno, T. | 登録日 | 2010-05-12 | 公開日 | 2010-05-26 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the K-turn U4 RNA: a combined NMR and SANS study. Nucleic Acids Res., 38, 2010
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