8QZ1
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![BU of 8qz1 by Molmil](/molmil-images/mine/8qz1) | Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with a nanobody (Nb58) | 分子名称: | Isoform B of Potassium channel subfamily K member 10, Nanobody 58, POTASSIUM ION | 著者 | Rodstrom, K.E.J, Pike, A.C.W, Baronina, A, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2023-10-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.588 Å) | 主引用文献 | Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024
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8QZ3
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![BU of 8qz3 by Molmil](/molmil-images/mine/8qz3) | Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb67) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Nanobody 67, POTASSIUM ION, ... | 著者 | Baronina, A, Pike, A.C.W, Rodstrom, K.E.J, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2023-10-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024
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8RDA
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8RND
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![BU of 8rnd by Molmil](/molmil-images/mine/8rnd) | Cathepsin S in complex with NNPI-C10 inhibitor | 分子名称: | 1,2-ETHANEDIOL, Cathepsin S, DI(HYDROXYETHYL)ETHER, ... | 著者 | Petruzzella, A, Lau, K, Pojer, F, Oricchio, E. | 登録日 | 2024-01-09 | 公開日 | 2024-06-05 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins. Nat.Chem.Biol., 2024
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4YEJ
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![BU of 4yej by Molmil](/molmil-images/mine/4yej) | Tailspike protein double mutant D339A/E372Q of E. coli bacteriophage HK620 in complex with pentasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-02-24 | 公開日 | 2016-03-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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8QZ4
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![BU of 8qz4 by Molmil](/molmil-images/mine/8qz4) | Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb76) | 分子名称: | BARIUM ION, CHOLESTEROL HEMISUCCINATE, Nanobody 76, ... | 著者 | Rodstrom, K.E.J, Pike, A.C.W, Baronina, A, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2023-10-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024
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8QBM
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6Z7C
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![BU of 6z7c by Molmil](/molmil-images/mine/6z7c) | Variant Surface Glycoprotein VSGsur mutant H122A | 分子名称: | Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Zeelen, J.P, Straaten van, M, Stebbins, C.E. | 登録日 | 2020-05-30 | 公開日 | 2021-03-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Structure of trypanosome coat protein VSGsur and function in suramin resistance. Nat Microbiol, 6, 2021
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5EWJ
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![BU of 5ewj by Molmil](/molmil-images/mine/5ewj) | |
8QBL
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6Z7E
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![BU of 6z7e by Molmil](/molmil-images/mine/6z7e) | |
8QBK
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![BU of 8qbk by Molmil](/molmil-images/mine/8qbk) | |
4YLQ
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![BU of 4ylq by Molmil](/molmil-images/mine/4ylq) | Crystal Structure of a FVIIa-Trypsin Chimera (FT) in Complex with Soluble Tissue Factor | 分子名称: | CALCIUM ION, Coagulation factor VII, N-PROPANOL, ... | 著者 | Sorensen, A.B, Svensson, L.A, Gandhi, P.S. | 登録日 | 2015-03-05 | 公開日 | 2015-12-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity. J.Biol.Chem., 291, 2016
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8QE4
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![BU of 8qe4 by Molmil](/molmil-images/mine/8qe4) | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions | 分子名称: | DNA (5'-D(*CP*(FRG)P*CP*(FRG)P*CP*(FRG))-3') | 著者 | El-Khoury, R, Cabrero, C, Movilla, S, Friedland, D, Thorpe, J.D, Roman, M, Orozco, M, Gonzalez, C, Damha, M. | 登録日 | 2023-08-30 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-31 | 実験手法 | SOLUTION NMR | 主引用文献 | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions. Nucleic Acids Res., 52, 2024
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8QOR
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![BU of 8qor by Molmil](/molmil-images/mine/8qor) | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions | 分子名称: | DNA (5'-D(*(CFL)P*(FRG)P*(CFL)P*(FRG)P*(CFL)P*(FRG))-3') | 著者 | El-Khoury, R, Cabrero, C, Movilla, S, Friedland, D, Thorpe, J.D, Roman, M, Orozco, M, Gonzalez, C, Damha, M. | 登録日 | 2023-09-29 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-31 | 実験手法 | SOLUTION NMR | 主引用文献 | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions. Nucleic Acids Res., 52, 2024
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4YIZ
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6Z7D
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![BU of 6z7d by Molmil](/molmil-images/mine/6z7d) | |
8QZJ
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![BU of 8qzj by Molmil](/molmil-images/mine/8qzj) | |
8RDU
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![BU of 8rdu by Molmil](/molmil-images/mine/8rdu) | Conformational Landscape of the Type V-K CRISPR-associated TransposonIntegration Assembly CAST V-K composite map | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, LE, MAGNESIUM ION, ... | 著者 | Tenjo-Castano, F, Mesa, P, Montoya, G. | 登録日 | 2023-12-08 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Conformational landscape of the type V-K CRISPR-associated transposon integration assembly. Mol.Cell, 84, 2024
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7T79
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![BU of 7t79 by Molmil](/molmil-images/mine/7t79) | |
7T78
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8QZI
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![BU of 8qzi by Molmil](/molmil-images/mine/8qzi) | Crystal structure of PptT-ACP from Mycobacterium tuberculosis | 分子名称: | 4'-phosphopantetheinyl transferase PptT, COENZYME A, ISOPROPYL ALCOHOL, ... | 著者 | Gavalda, S, Mourey, L, Pedelacq, J.D. | 登録日 | 2023-10-27 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Catalytic Cycle of Type II 4'-Phosphopantetheinyl Transferases Acs Catalysis, 14, 2024
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8R7Y
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![BU of 8r7y by Molmil](/molmil-images/mine/8r7y) | Deoxyribonucleoside regulator DeoR in complex with the DNA operator | 分子名称: | Deoxyribonucleoside regulator, OL18 DNA operator, strand 1, ... | 著者 | Pachl, P, Soltysova, M, Rezacova, P. | 登録日 | 2023-11-27 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Structural characterization of two prototypical repressors of SorC family reveals tetrameric assemblies on DNA and mechanism of function. Nucleic Acids Res., 52, 2024
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8RPJ
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![BU of 8rpj by Molmil](/molmil-images/mine/8rpj) | JanthE from Janthinobacterium sp. HH01 | 分子名称: | ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | 著者 | Lanza, L, Leogrande, C, Rabe von Pappenheim, F, Tittmann, K, Mueller, M. | 登録日 | 2024-01-16 | 公開日 | 2024-06-12 | 最終更新日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Identification and Characterization of Thiamine Diphosphate-Dependent Lyases with an Unusual CDG Motif. Angew.Chem.Int.Ed.Engl., 63, 2024
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8QQI
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![BU of 8qqi by Molmil](/molmil-images/mine/8qqi) | |