PDB: 5653 件ウェブページステータス検索Chemie searchBIRD

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5V4L	Cryptococcus neoformans adenylosuccinate lyase 分子名称: Adenylosuccinate lyase 著者 Chitty, J, Williams, S.J, Kobe, B, Fraser, J.A. 登録日 2017-03-09 公開日 2017-06-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. J. Biol. Chem., 292, 2017
4NLE	Crystal structure of apo Adenylosuccinate Lyase from Mycobacterium smegmatis 分子名称: Adenylosuccinate lyase 著者 Banerjee, S, Murthy, M.R.N. 登録日 2013-11-14 公開日 2014-03-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Structural and kinetic studies on adenylosuccinate lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme. Febs J., 281, 2014
7K46	Crystal Structure of a putative aspartate carbamoyltransferase Leishmania major Friedlin 分子名称: 1,2-ETHANEDIOL, Aspartate carbamoyltransferase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2020-09-14 公開日 2020-09-30 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure of a putative aspartate carbamoyltransferase Leishmania major Friedlin to be published
4MUZ	Crystal structure of orotidine 5'-monophosphate decarboxylase from Archaeoglobus fulgidus complexed with inhibitor BMP 分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, Orotidine 5'-phosphate decarboxylase 著者 Fedorov, A.A, Fedorov, E.V, Desai, B, Gerlt, J.A, Almo, S.C. 登録日 2013-09-23 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Crystal structure of orotidine 5'-monophosphate decarboxylase from Archaeoglobus fulgidus complexed with inhibitor BMP To be Published
6TAI	Crystal structure of Escherichia coli Orotate Phosphoribosyltransferase with an empty active site at 1.55 Angstrom resolution 分子名称: ACETATE ION, GLYCEROL, Orotate phosphoribosyltransferase 著者 Navas-Yuste, S, Lopez-Estepa, M, Gomez, S, Fernandez, F.J, Vega, M.C. 登録日 2019-10-29 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.551 Å) 主引用文献 Elucidating the Catalytic Reaction Mechanism of Orotate Phosphoribosyltransferase by Means of X-ray Crystallography and Computational Simulations Acs Catalysis, 10, 2020
4O11	Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-hydroxyuridine 5'-monophosphate 分子名称: 1,2-ETHANEDIOL, 6-HYDROXYURIDINE-5'-PHOSPHATE, CHLORIDE ION, ... 著者 Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. 登録日 2013-12-14 公開日 2014-01-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-hydroxyuridine 5'-monophosphate To be Published
4O8R	Crystal structure of orotidine 5'-monophosphate decarboxylase from methanobacterium thermoautotrophicum complexed with 5,6-dihydrouridine 5'-monophosphate 分子名称: 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE, CHLORIDE ION, Orotidine 5'-phosphate decarboxylase 著者 Fedorov, A.A, Fedorov, E.V, Chan, K.K, Gerlt, J.A, Almo, S.C. 登録日 2013-12-29 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.293 Å) 主引用文献 Crystal structure of orotidine 5'-monophosphate decarboxylase from methanobacterium thermoautotrophicum complexed with 5,6-dihydrouridine 5'-monophosphate To be Published
4ORI	Rat dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine) 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... 著者 Deng, X, Phillips, M.A. 登録日 2014-02-11 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors. J.Med.Chem., 57, 2014
4LS0	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH01B0033 分子名称: 2-{(E)-[2-(4-phenyl-1,3-thiazol-2-yl)hydrazinylidene]methyl}benzaldehyde, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... 著者 Zhu, L, Li, H, Ren, X, Zhu, J. 登録日 2013-07-21 公開日 2014-07-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DHO1B0033 To be Published
5KSW	DHODB-I74D mutant 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Dihydroorotate dehydrogenase, ... 著者 Pompeu, Y.A, Stewart, J.D. 登録日 2016-07-10 公開日 2016-08-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Isoleucine 74 Plays a Key Role in Controlling Electron Transfer Between Lactococcus lactis Dihydroorotate Dehydrogenase 1B Subunits To Be Published
4OQV	High resolution crystal structure of human dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine) 分子名称: ACETIC ACID, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... 著者 Deng, X, Phillips, M.A. 登録日 2014-02-10 公開日 2014-06-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors. J.Med.Chem., 57, 2014
5VMQ	STRUCTURE OF THE R105A MUTANT CATALYTIC TRIMER OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE AT 2.0-A RESOLUTION 分子名称: Aspartate carbamoyltransferase, CALCIUM ION, CHLORIDE ION 著者 Beernink, P.T, Endrizzi, J.A. 登録日 2017-04-28 公開日 2017-05-24 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.012 Å) 主引用文献 Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes. Protein Sci., 26, 2017
4N2Y	Crystal structure of orotidine 5'-monophosphate decarboxylase from Archaeoglobus fulgidus 分子名称: GLYCEROL, Orotidine 5'-phosphate decarboxylase 著者 Fedorov, A.A, Fedorov, E.V, Desai, B, Gerlt, J.A, Almo, S.C. 登録日 2013-10-06 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.549 Å) 主引用文献 Crystal structure of orotidine 5'-monophosphate decarboxylase from Archaeoglobus fulgidus To be Published
7MX6	Leishmania major dihydroorotate dehydrogenase in complex with [4-(1H-pyrrol-1-yl)phenyl]methanol 分子名称: 4-(1H-pyrrol-1-yl)aniline, Dihydroorotate dehydrogenase (fumarate), FLAVIN MONONUCLEOTIDE, ... 著者 Pinheiro, M.P, Hunter, W.N, Cardoso, I.A, Nonato, M.C. 登録日 2021-05-18 公開日 2022-05-18 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Leishmania major dihydroorotate dehydrogenase in complex with [4-(1H-pyrrol-1-yl)phenyl]methanol To be Published
5VKW	Crystal structure of adenylosuccinate lyase ADE13 from Candida albicans 分子名称: Adenylosuccinate lyase, CALCIUM ION, CHLORIDE ION, ... 著者 Stogios, P.J, Evdokimova, E, Di Leo, R, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2017-04-24 公開日 2017-05-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.998 Å) 主引用文献 Crystal structure of adenylosuccinate lyase ADE13 from Candida albicans To Be Published
1PL0	Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC 分子名称: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Bifunctional purine biosynthesis protein PURH, N-(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO]SULFONYL}BENZOYL)GLUTAMIC ACID, ... 著者 Cheong, C.G, Greasley, S.E, Horton, P.A, Beardsley, G.P, Wilson, I.A. 登録日 2003-06-06 公開日 2004-04-27 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates. J.Biol.Chem., 279, 2004
4NSL	X-ray Crystal structure of Adenylosuccinate Lyase from Salmonella typhimurium 分子名称: Adenylosuccinate lyase, PENTANE-1,5-DIAMINE 著者 Banerjee, S, Agrawal, M.J, Murthy, M.R.N. 登録日 2013-11-28 公開日 2014-12-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystallographic and kinetic studies on Adenylosuccinate Lyase from Salmonella typhimurium To be Published
4NUW	Crystal structure of orotidine 5'-monophosphate decarboxylase from methanobacterium thermoautotrophicum complexed with uridine 5'-monophosphate 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Orotidine 5'-phosphate decarboxylase, ... 著者 Fedorov, A.A, Fedorov, E.V, Chan, K.K, Gerlt, J.A, Almo, S.C. 登録日 2013-12-04 公開日 2013-12-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.591 Å) 主引用文献 Crystal structure of orotidine 5'-monophosphate decarboxylase from methanobacterium thermoautotrophicum complexed with uridine 5'-monophosphate To be Published
8JBD	Crystal structure of Adenylosuccinate lyase from Thermus thermophilus HB8, TtPurB 分子名称: Adenylosuccinate lyase 著者 Nemoto, N, Kawai, G, Sampei, G. 登録日 2023-05-08 公開日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Crystal structure of adenylosuccinate lyase from the thermophilic bacterium Thermus thermophilus HB8. Acta Crystallogr.,Sect.F, 79, 2023
1X1Z	Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump) 分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, Orotidine 5'-phosphate decarboxylase 著者 Fujihashi, M, Bello, A.M, Poduch, E, Wei, L, Annedi, S.C, Pai, E.F, Kotra, L.P. 登録日 2005-04-15 公開日 2005-12-06 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 An unprecedented twist to ODCase catalytic activity J.Am.Chem.Soc., 127, 2005
6F4L	Structure of quinolinate synthase with inhibitor-derived quinolinate 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CHLORIDE ION, IRON/SULFUR CLUSTER, ... 著者 Volbeda, A, Fontecilla-Camps, J.C. 登録日 2017-11-29 公開日 2018-04-25 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystallographic Trapping of Reaction Intermediates in Quinolinic Acid Synthesis by NadA. ACS Chem. Biol., 13, 2018
1PG5	CRYSTAL STRUCTURE OF THE UNLIGATED (T-STATE) ASPARTATE TRANSCARBAMOYLASE FROM THE EXTREMELY THERMOPHILIC ARCHAEON SULFOLOBUS ACIDOCALDARIUS 分子名称: Aspartate carbamoyltransferase, Aspartate carbamoyltransferase regulatory chain, ZINC ION 著者 De Vos, D, Van Petegem, F, Remaut, H, Legrain, C, Glansdorff, N, Van Beeumen, J.J. 登録日 2003-05-27 公開日 2004-06-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure of T State Aspartate Carbamoyltransferase of the Hyperthermophilic Archaeon Sulfolobus acidocaldarius. J.Mol.Biol., 339, 2004
1XGE	Dihydroorotase from Escherichia coli: Loop Movement and Cooperativity between subunits 分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, Dihydroorotase, N-CARBAMOYL-L-ASPARTATE, ... 著者 Lee, M, Chan, C.W, Guss, J.M, Christopherson, R.I, Maher, M.J. 登録日 2004-09-17 公開日 2005-04-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Dihydroorotase from Escherichia coli: Loop Movement and Cooperativity between Subunits J.Mol.Biol., 348, 2005
5MUT	Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds 分子名称: 2-methyl-5-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]-1,2,3-triazole-4-carboxamide, ACETATE ION, CHLORIDE ION, ... 著者 Goyal, P, Andersson, M, Moritzer, A.C, Sainas, S, Pippione, A.C, Boschi, D, Al-Kadaraghi, S, Lolli, M, Friemann, R. 登録日 2017-01-14 公開日 2017-03-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur J Med Chem, 129, 2017
1ZA1	Structure of wild-type E. coli Aspartate Transcarbamoylase in the presence of CTP at 2.20 A resolution 分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... 著者 Wang, J, Stieglitz, K.A, Cardia, J.P, Kantrowitz, E.R. 登録日 2005-04-05 公開日 2005-06-07 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis for ordered substrate binding and cooperativity in aspartate transcarbamoylase Proc.Natl.Acad.Sci.Usa, 102, 2005

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