5V4L

Cryptococcus neoformans adenylosuccinate lyase

Summary for 5V4L

Entry DOI	10.2210/pdb5v4l/pdb
Descriptor	Adenylosuccinate lyase (2 entities in total)
Functional Keywords	lyase, fumerase, adenylosuccinate, saicar
Biological source	Cryptococcus neoformans
Total number of polymer chains	4
Total formula weight	214849.42
Authors	Chitty, J.,Williams, S.J.,Kobe, B.,Fraser, J.A. (deposition date: 2017-03-09, release date: 2017-06-07, Last modification date: 2023-10-04)
Primary citation	Chitty, J.L.,Blake, K.L.,Blundell, R.D.,Koh, Y.Q.A.E.,Thompson, M.,Robertson, A.A.B.,Butler, M.S.,Cooper, M.A.,Kappler, U.,Williams, S.J.,Kobe, B.,Fraser, J.A. Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. J. Biol. Chem., 292:11829-11839, 2017 Cited by PubMed: 28559277 DOI: 10.1074/jbc.M117.787994 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation