2SQC
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2TNF
| 1.4 A RESOLUTION STRUCTURE OF MOUSE TUMOR NECROSIS FACTOR, TOWARDS MODULATION OF ITS SELECTIVITY AND TRIMERISATION | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ISOPROPYL ALCOHOL, PROTEIN (TUMOR NECROSIS FACTOR ALPHA) | 著者 | Baeyens, K.J, De Bondt, H.L, Raeymaekers, A, Fiers, W, De Ranter, C.J. | 登録日 | 1998-10-12 | 公開日 | 1999-10-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | The structure of mouse tumour-necrosis factor at 1.4 A resolution: towards modulation of its selectivity and trimerization. Acta Crystallogr.,Sect.D, 55, 1999
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2TRX
| CRYSTAL STRUCTURE OF THIOREDOXIN FROM ESCHERICHIA COLI AT 1.68 ANGSTROMS RESOLUTION | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, COPPER (II) ION, THIOREDOXIN | 著者 | Katti, S.K, Lemaster, D.M, Eklund, H. | 登録日 | 1990-03-19 | 公開日 | 1991-10-15 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Crystal structure of thioredoxin from Escherichia coli at 1.68 A resolution. J.Mol.Biol., 212, 1990
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7EU9
| Crystal structure of the selenomethionine(SeMet)-derived Cas12i1 R-loop complex before target DNA cleavage | 分子名称: | CITRIC ACID, Cas12i1 D647A mutant, DNA (24-MER), ... | 著者 | Zhang, B, Luo, D.Y, Li, Y, OuYang, S.Y. | 登録日 | 2021-05-16 | 公開日 | 2021-05-26 | 最終更新日 | 2021-06-23 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1. Nat Commun, 12, 2021
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7EZL
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7BP3
| Cryo-EM structure of the human MCT2 | 分子名称: | Monocarboxylate transporter 2 | 著者 | Zhang, B, Jin, Q, Zhang, X, Guo, J, Ye, S. | 登録日 | 2020-03-21 | 公開日 | 2020-06-03 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cooperative transport mechanism of human monocarboxylate transporter 2. Nat Commun, 11, 2020
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7EZI
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6NSO
| An Unexpected Intermediate in the Reaction Catalyzed by Quinolinate Synthase | 分子名称: | 1,3-DIHYDROXYACETONEPHOSPHATE, IRON/SULFUR CLUSTER, Quinolinate synthase A | 著者 | Esakova, O.A, Grove, T.L, Silakov, A, Yennawar, N.H, Booker, S.J. | 登録日 | 2019-01-25 | 公開日 | 2019-10-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | An Unexpected Species Determined by X-ray Crystallography that May Represent an Intermediate in the Reaction Catalyzed by Quinolinate Synthase. J.Am.Chem.Soc., 141, 2019
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6NY3
| CasX ternary complex with 30bp target DNA | 分子名称: | CasX, DNA Non-target strand, DNA target strand, ... | 著者 | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | 登録日 | 2019-02-10 | 公開日 | 2019-02-27 | 最終更新日 | 2019-12-25 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | CasX enzymes comprise a distinct family of RNA-guided genome editors. Nature, 566, 2019
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7KG3
| Crystal structure of CoV-2 Nsp3 Macrodomain | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, MALONATE ION, ... | 著者 | Arvai, A, Brosey, C.A, Link, T, Jones, D.E, Ahmed, Z, Tainer, J.A. | 登録日 | 2020-10-15 | 公開日 | 2020-10-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog.Biophys.Mol.Biol., 163, 2021
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7BY6
| Plasmodium vivax cytoplasmic Phenylalanyl-tRNA synthetase in complex with BRD1389 | 分子名称: | (3S,4R,8R,9R,10S)-N-(4-cyclopropyloxyphenyl)-10-(methoxymethyl)-3,4-bis(oxidanyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide, MAGNESIUM ION, Phenylalanyl-tRNA synthetase beta chain, ... | 著者 | Malhotra, N, Manmohan, S, Harlos, K, Melillo, B, Schreiber, S.L, Manickam, Y, Sharma, S. | 登録日 | 2020-04-21 | 公開日 | 2020-11-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.997 Å) | 主引用文献 | Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines. Nat Commun, 12, 2021
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8SLT
| Crystal structure of human STEP (PTPN5) at physiological temperature (310 K) and ambient pressure (0.1 MPa) | 分子名称: | SULFATE ION, Tyrosine-protein phosphatase non-receptor type 5 | 著者 | Ebrahim, A, Guerrero, L, Riley, B.T, Kim, M, Huang, Q, Finke, A.D, Keedy, D.A. | 登録日 | 2023-04-24 | 公開日 | 2023-06-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase. Biorxiv, 2023
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6AH3
| Cryo-EM structure of yeast Ribonuclease P with pre-tRNA substrate | 分子名称: | MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, ... | 著者 | Lan, P, Tan, M, Wu, J, Lei, M. | 登録日 | 2018-08-16 | 公開日 | 2018-10-17 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | Structural insight into precursor tRNA processing by yeast ribonuclease P. Science, 362, 2018
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8T8C
| Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | 著者 | Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R. | 登録日 | 2023-06-22 | 公開日 | 2023-07-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023
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6AKJ
| The crystal structure of EMC complex | 分子名称: | Enhancer of rudimentary homolog,YTH domain-containing protein mmi1 fusion protein, SULFATE ION | 著者 | Li, F. | 登録日 | 2018-09-01 | 公開日 | 2019-02-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing. Nat Commun, 10, 2019
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6NN9
| REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE N9, ... | 著者 | Tulip, W.R, Varghese, J.N, Baker, A.T, Vandonkelaar, A, Laver, W.G, Webster, R.G, Colman, P.M. | 登録日 | 1991-03-28 | 公開日 | 1992-07-15 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants. J.Mol.Biol., 221, 1991
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8SZO
| Canavalia villosa lectin in complex with alpha-methyl-mannoside | 分子名称: | CALCIUM ION, Canavalia villosa lectin, GLYCEROL, ... | 著者 | Cavada, B.S, Lossio, C.F, Pinto-Junior, V.R, Osterne, V.J.S, Oliveira, M.V, Neco, A.H.B, Nascimento, K.S. | 登録日 | 2023-05-30 | 公開日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Lectin from Canavalia villosa seeds: A glucose/mannose-specific protein and a new tool for inflammation studies. Int J Biol Macromol, 105, 2017
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4CMG
| Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor | 分子名称: | 6-(4-fluorophenyl)-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Barrack, K.L, Hunter, W.N. | 登録日 | 2014-01-16 | 公開日 | 2015-01-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57, 2014
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6AME
| TYPE III ANTIFREEZE PROTEIN ISOFORM HPLC 12 M21A | 分子名称: | PROTEIN (ANTIFREEZE PROTEIN TYPE III) | 著者 | Graether, S.P, Deluca, C.I, Baardsnes, J, Hill, G.A, Davies, P.L, Jia, Z. | 登録日 | 1999-01-24 | 公開日 | 1999-04-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Quantitative and qualitative analysis of type III antifreeze protein structure and function. J.Biol.Chem., 274, 1999
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4CLR
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4CMC
| Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor | 分子名称: | N4-cyclohexyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE 1 | 著者 | Barrack, K.L, Hunter, W.N. | 登録日 | 2014-01-16 | 公開日 | 2015-01-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57, 2014
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6NU3
| Structural insights into unique features of the human mitochondrial ribosome recycling | 分子名称: | 12S rRNA, 16S rRNA, 28S ribosomal protein S10, ... | 著者 | Sharma, M.R, Koripella, R.K, Agrawal, R.K. | 登録日 | 2019-01-30 | 公開日 | 2019-04-17 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structural insights into unique features of the human mitochondrial ribosome recycling. Proc.Natl.Acad.Sci.USA, 116, 2019
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4CLH
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4CM9
| Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-amino-5,6-diphenyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one, ACETATE ION, ... | 著者 | Barrack, K.L, Hunter, W.N. | 登録日 | 2014-01-15 | 公開日 | 2015-01-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57, 2014
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6ABP
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