PDB: 222624 件ウェブページステータス検索Chemie searchBIRD

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4G6P	Minimal Hairpin Ribozyme in the Precatalytic State with A38P Variation 分子名称: COBALT HEXAMMINE(III), Loop A Substrate strand, Loop A and Loop B Ribozyme strand, ... 著者 Liberman, J.A, Jenkins, J.L, Krucinska, J, Wedekind, J.E. 登録日 2012-07-19 公開日 2012-08-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.641 Å) 主引用文献 A Transition-State Interaction Shifts Nucleobase Ionization toward Neutrality To Facilitate Small Ribozyme Catalysis. J.Am.Chem.Soc., 134, 2012
4G6S	Minimal Hairpin Ribozyme in the Transition State with A38P Variation 分子名称: COBALT HEXAMMINE(III), Loop A Substrate strand, Loop A and Loop B Ribozyme strand, ... 著者 Liberman, J.A, Jenkins, J.L, Krucinska, J, Wedekind, J.E. 登録日 2012-07-19 公開日 2012-08-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 A Transition-State Interaction Shifts Nucleobase Ionization toward Neutrality To Facilitate Small Ribozyme Catalysis. J.Am.Chem.Soc., 134, 2012
3VYY	Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase A (DHX9) 分子名称: ATP-dependent RNA helicase A, RNA (5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*C)-3') 著者 Yuan, Y.A, Fu, Q. 登録日 2012-10-05 公開日 2013-02-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9). Nucleic Acids Res., 41, 2013
1NH6	Structure of S. marcescens chitinase A, E315L, complex with hexasaccharide 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, chitinase A 著者 Aronson Jr, N.N, Halloran, B.A, Alexyev, M.F, Amable, L, Madura, J.D, Pasupulati, L, Worth, C, Van Roey, P. 登録日 2002-12-18 公開日 2003-03-18 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Family 18 chitinase-oligosaccharide substrate interaction: subsite preference and anomer selectivity of Serratia marcescens chitinase A. Biochem.J., 376, 2003
3VHK	Crystal structure of the VEGFR2 kinase domain in complex with a back pocket binder 分子名称: 1,2-ETHANEDIOL, Vascular endothelial growth factor receptor 2, {3-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl}methanol 著者 Iwata, H, Oki, H, Okada, K, Takagi, T, Tawada, M, Miyazaki, Y, Imamura, S, Hori, A, Hixon, M.S, Kimura, H, Miki, H. 登録日 2011-08-25 公開日 2012-09-05 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases. ACS MED.CHEM.LETT., 3, 2012
3IID	Crystal structure of the macro domain of human histone macroH2A1.1 in complex with ADP-ribose (form A) 分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, Core histone macro-H2A.1, Isoform 1, ... 著者 Hothorn, M, Bortfeld, M, Ladurner, A.G, Scheffzek, K. 登録日 2009-07-31 公開日 2009-08-18 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nat.Struct.Mol.Biol., 16, 2009
5OTJ	Monomeric polcalcin (Phl p 7) in complex with two identical allergen-specific antibodies 分子名称: 1,2-ETHANEDIOL, 102.1F10 Fab heavy chain, 102.1F10 Fab light chain, ... 著者 Mitropoulou, A.N, Davies, A.M, Beavil, A.J, McDonnell, J.M, Sutton, B.J. 登録日 2017-08-22 公開日 2018-09-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3VID	Crystal structure of human VEGFR2 kinase domain with Compound A. 分子名称: 4,5,6,11-tetrahydro-1H-pyrazolo[4',3':6,7]cyclohepta[1,2-b]indole, Vascular endothelial growth factor receptor 2 著者 Iwata, H, Oki, H, Okada, K, Takagi, T, Tawada, M, Miyazaki, Y, Imamura, S, Hori, A, Hixon, M.S, Kimura, H, Miki, H. 登録日 2011-09-29 公開日 2012-08-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases. ACS MED.CHEM.LETT., 3, 2012
4EUA	Succinyl-CoA:acetate CoA-transferase (AarCH6-R228E) in complex with CoA (anomalous dataset) 分子名称: CHLORIDE ION, COENZYME A, Succinyl-CoA:acetate coenzyme A transferase 著者 Mullins, E.A, Kappock, T.J. 登録日 2012-04-25 公開日 2012-10-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.398 Å) 主引用文献 Crystal Structures of Acetobacter aceti Succinyl-Coenzyme A (CoA):Acetate CoA-Transferase Reveal Specificity Determinants and Illustrate the Mechanism Used by Class I CoA-Transferases. Biochemistry, 51, 2012
1AV2	Gramicidin A/CsCl complex, active as a dimer 分子名称: CESIUM ION, CHLORIDE ION, GRAMICIDIN A, ... 著者 Burkhart, B.M, Li, N, Langs, D.A, Duax, W.L. 登録日 1997-09-23 公開日 1998-07-01 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 The Conducting Form of Gramicidin a is a Right-Handed Double-Stranded Double Helix. Proc.Natl.Acad.Sci.USA, 95, 1998
4E8F	Structural Basis for the Activity of a Cytoplasmic RNA Terminal U-transferase 分子名称: ACETATE ION, GLYCEROL, Poly(A) RNA polymerase protein cid1 著者 Yates, L.A, Fleurdepine, S, Rissland, O.S, DeColibus, L, Harlos, K, Norbury, C.J, Gilbert, R.J.C. 登録日 2012-03-20 公開日 2012-07-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase. Nat.Struct.Mol.Biol., 19, 2012
3NOX	Crystal structure of human DPP-IV in complex with Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl-peptidase 4 (CD26, ... 著者 Klei, H.E. 登録日 2010-06-25 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.338 Å) 主引用文献 Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors. J.Med.Chem., 53, 2010
4KTX	Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134S mutant with covalent inhibitor that modifies Cys-165 causing disorder in 167-174 stretch 分子名称: Botulinum neurotoxin A light chain, GLYCEROL, Peptide inhibitor MPT-DPP-ARG-G-LEU-NH2, ... 著者 Stura, E.A, Vera, L, Guitot, K, Dive, V. 登録日 2013-05-21 公開日 2014-10-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A To be Published
4IAU	Atomic resolution structure of Geodin, a beta-gamma crystallin from Geodia cydonium 分子名称: Beta-gamma-crystallin, CALCIUM ION, GLYCEROL 著者 Vergara, A, Grassi, M, Sica, F, Mazzarella, L, Merlino, A. 登録日 2012-12-07 公開日 2013-06-05 実験手法 X-RAY DIFFRACTION (0.99 Å) 主引用文献 A novel interdomain interface in crystallins: structural characterization of the [beta][gamma]-crystallin from Geodia cydonium at 0.99 A resolution Acta Crystallogr.,Sect.D, 69, 2013
4EU7	Succinyl-CoA:acetate CoA-transferase (AarCH6) in complex with CoA and citrate 分子名称: CHLORIDE ION, CITRIC ACID, COENZYME A, ... 著者 Mullins, E.A, Kappock, T.J. 登録日 2012-04-25 公開日 2012-10-10 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structures of Acetobacter aceti Succinyl-Coenzyme A (CoA):Acetate CoA-Transferase Reveal Specificity Determinants and Illustrate the Mechanism Used by Class I CoA-Transferases. Biochemistry, 51, 2012
4E7X	Structural Basis for the Activity of a Cytoplasmic RNA Terminal U-transferase 分子名称: ACETATE ION, Poly(A) RNA polymerase protein cid1 著者 Yates, L.A, Fleurdepine, S, Rissland, O.S, DeColibus, L, Harlos, K, Norbury, C.J, Gilbert, R.J.C. 登録日 2012-03-19 公開日 2012-07-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase. Nat.Struct.Mol.Biol., 19, 2012
4IJH	Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A 分子名称: 3-chloro-6-[3-(4-fluorophenyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]-1-benzothiophene-2-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit 著者 Feldkamp, M.D, Patrone, J.D, Kennedy, J.P, Frank, A.O, Vangamudi, B, Pelz, N.F, Rossanese, O.W, Waterson, A.G, Fesik, S.W, Chazin, W.J. 登録日 2012-12-21 公開日 2013-08-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.498 Å) 主引用文献 Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. ACS MED.CHEM.LETT., 4, 2013
4LNS	Crystal structure of Asparagine synthetase A (AsnA) from Trypanosoma brucei 分子名称: Asparagine synthetase a 著者 Khan, S, Madhubala, R, Sharma, A. 登録日 2013-07-12 公開日 2014-03-19 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Identification and functional characterization of a novel bacterial type asparagine synthetase A: a tRNA synthetase paralog from Leishmania donovani. J.Biol.Chem., 289, 2014
5O39	Human Brd2(BD2) mutant in complex with ME 分子名称: (2~{S})-1-[(2~{S})-2-oxidanylpropoxy]propan-2-ol, Bromodomain-containing protein 2, CHLORIDE ION, ... 著者 Runcie, A.C, Chan, K.-H, Ciulli, A. 登録日 2017-05-23 公開日 2018-02-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition. Chem Sci, 9, 2018
5O3F	Human Brd2(BD2) mutant in complex with ET-Am1 分子名称: (2~{R})-2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-~{N}-ethyl-butanamide, (2~{S})-1-[(2~{S})-2-oxidanylpropoxy]propan-2-ol, Bromodomain-containing protein 2, ... 著者 Runcie, A.C, Chan, K.-H, Ciulli, A. 登録日 2017-05-23 公開日 2018-02-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition. Chem Sci, 9, 2018
4IRY	Influenza A virus tail-loop free nucleoprotein at 2.8 A resolution 分子名称: Nucleocapsid protein 著者 Ye, Q, Mata, D.A, Tao, Y.J. 登録日 2013-01-15 公開日 2013-02-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Biochemical and structural evidence in support of a coherent model for the formation of the double-helical influenza a virus ribonucleoprotein. MBio, 4, 2012
3FGH	Human mitochondrial transcription factor A box B 分子名称: CADMIUM ION, CHLORIDE ION, SODIUM ION, ... 著者 Gangelhoff, T.A, Mungalachetty, P, Nix, J, Churchill, M.E.A. 登録日 2008-12-06 公開日 2009-04-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structural analysis and DNA binding of the HMG domains of the human mitochondrial transcription factor A Nucleic Acids Res., 37, 2009
1XFD	Structure of a human A-type Potassium Channel Accelerating factor DPPX, a member of the dipeptidyl aminopeptidase family 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl aminopeptidase-like protein 6, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Strop, P, Bankovich, A.J, Hansen, K.C, Garcia, K.C, Brunger, A.T. 登録日 2004-09-14 公開日 2004-10-26 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family J.Mol.Biol., 343, 2004
4NM8	Crystal structure of broadly neutralizing antibody CR8043 bound to H3 influenza hemagglutinin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody CR8043, ... 著者 Lee, P.S, Wilson, I.A. 登録日 2013-11-14 公開日 2013-12-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (4.0041 Å) 主引用文献 A common solution to group 2 influenza virus neutralization. Proc.Natl.Acad.Sci.USA, 111, 2014
4CP9	Crystal structure OF lecA lectin complexed with a divalent galactoside at 1.65 angstrom 分子名称: (4S)-N-ethyl-4-{[N-methyl-3-(1-{2-[(4-sulfanylbenzoyl)amino]ethyl}-1H-1,2,3-triazol-4-yl)-L-alanyl]amino}-L-prolinamide, 1,2-ETHANEDIOL, CALCIUM ION, ... 著者 Topin, J, Varrot, A, Imberty, A, Wissinger, N. 登録日 2014-02-04 公開日 2014-10-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 A Leca Ligand Identified from a Galactoside-Conjugate Array Inhibits Host Cell Invasion by Pseudomonas Aeruginosa. Angew.Chem.Int.Ed.Engl., 53, 2014

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