8WTR
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![BU of 8wtr by Molmil](/molmil-images/mine/8wtr) | HUMAN SQUALENE SYNTHASE IN COMPLEX WITH (1S,3R)-3-[2-Chloro-5-(2,2-dimethyl-propyl)-13-(2-methoxy-phenyl)-6,8-dioxo-5,6,7,8,10,11-hexahydro-13H-12-oxa-5,9-diaza-benzocycloundecen-9-yl]-cyclohexanecarboxylic acid | 分子名称: | (1~{S},3~{R})-3-[(10~{S})-13-chloranyl-2-(2,2-dimethylpropyl)-10-(2-methoxyphenyl)-3,5-bis(oxidanylidene)-9-oxa-2,6-diazabicyclo[9.4.0]pentadeca-1(15),11,13-trien-6-yl]cyclohexane-1-carboxylic acid, PHOSPHATE ION, Squalene synthase | 著者 | Suzuki, M, Haginoya, N, Suzuki, M, Ishigai, Y, Terayama, K, Kanda, A, Sugita, K. | 登録日 | 2023-10-19 | 公開日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors. J.Med.Chem., 67, 2024
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8WTQ
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![BU of 8wtq by Molmil](/molmil-images/mine/8wtq) | HUMAN SQUALENE SYNTHASE IN COMPLEX WITH {1-[2-Chloro-5-(2,2-dimethyl-propyl)-13-(2-methoxy-phenyl)-6-oxo-6,7,10,11-tetrahydro-5H,9H,13H-12-oxa-5,8-diaza-benzocycloundecene-8-carbonyl]-piperidin-4-yl}-acetic acid | 分子名称: | 2-[1-[[(10~{S})-13-chloranyl-2-(2,2-dimethylpropyl)-10-(2-methoxyphenyl)-3-oxidanylidene-9-oxa-2,5-diazabicyclo[9.4.0]pentadeca-1(15),11,13-trien-5-yl]carbonyl]piperidin-4-yl]ethanoic acid, PHOSPHATE ION, Squalene synthase | 著者 | Suzuki, M, Haginoya, N, Suzuki, M, Ishigai, Y, Terayama, K, Kanda, A, Sugita, K. | 登録日 | 2023-10-19 | 公開日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors. J.Med.Chem., 67, 2024
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8WTK
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![BU of 8wtk by Molmil](/molmil-images/mine/8wtk) | Crystal structure of Cas3-DExD+MG | 分子名称: | CRISPR-associated helicase Cas3, MAGNESIUM ION | 著者 | Mo, X. | 登録日 | 2023-10-18 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | 主引用文献 | Structural insight into dynamic characteristic of the polymerized forms of kinetoplastid membrane protein-11 To be published
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8WTJ
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![BU of 8wtj by Molmil](/molmil-images/mine/8wtj) | XBB.1.5.70 spike protein in complex with ACE2 | 分子名称: | Processed angiotensin-converting enzyme 2, Spike glycoprotein | 著者 | Feng, L.L, Feng, L.L. | 登録日 | 2023-10-18 | 公開日 | 2023-12-13 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.64 Å) | 主引用文献 | Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding. Plos Pathog., 19, 2023
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8WTH
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![BU of 8wth by Molmil](/molmil-images/mine/8wth) | Crystal structure of Cas3-HD | 分子名称: | HD Cas3-type domain-containing protein | 著者 | Mo, X. | 登録日 | 2023-10-18 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Structural insight into dynamic characteristic of the polymerized forms of kinetoplastid membrane protein-11 To be published
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8WTF
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![BU of 8wtf by Molmil](/molmil-images/mine/8wtf) | The Crystal Structure of IRAK4 from Biortus | 分子名称: | 1,2-ETHANEDIOL, 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide, Interleukin-1 receptor-associated kinase 4, ... | 著者 | Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y. | 登録日 | 2023-10-18 | 公開日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Crystal Structure of IRAK4 from Biortus To Be Published
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8WTE
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![BU of 8wte by Molmil](/molmil-images/mine/8wte) | Crystal structure of TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide (VVGAVGVGK) | 分子名称: | Beta-2-microglobulin, KRAS-G12V nonamer peptide, MHC class I antigen (Fragment), ... | 著者 | Zhang, M.Y, Luo, L.J, Xu, W, Guan, F.H, Wang, X.Y, Zhu, P, Zhang, J.H, Zhou, X.Y, Wang, F, Ye, S. | 登録日 | 2023-10-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Identification and affinity enhancement of T-cell receptor targeting a KRAS G12V cancer neoantigen. Commun Biol, 7, 2024
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8WTD
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![BU of 8wtd by Molmil](/molmil-images/mine/8wtd) | XBB.1.5.10 RBD in complex with ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S2' | 著者 | Feng, L.L, Feng, L.L. | 登録日 | 2023-10-18 | 公開日 | 2023-12-13 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding. Plos Pathog., 19, 2023
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8WTC
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![BU of 8wtc by Molmil](/molmil-images/mine/8wtc) | |
8WTB
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![BU of 8wtb by Molmil](/molmil-images/mine/8wtb) | |
8WT9
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![BU of 8wt9 by Molmil](/molmil-images/mine/8wt9) | Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, donor DNA, and target DNA in the post-strand exchange state (Holliday junction resolution) | 分子名称: | IS621 transposase, MAGNESIUM ION, bridge RNA, ... | 著者 | Hiraizumi, M, Yamashita, K, Nishimasu, H. | 登録日 | 2023-10-18 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mechanism of bridge RNA-guided recombination. Nature, 630, 2024
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8WT8
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![BU of 8wt8 by Molmil](/molmil-images/mine/8wt8) | Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, donor DNA, and target DNA in the post-strand exchange state (Holliday junction intermediate) | 分子名称: | IS621 transposase, MAGNESIUM ION, bridge RNA, ... | 著者 | Hiraizumi, M, Yamashita, K, Nishimasu, H. | 登録日 | 2023-10-18 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mechanism of bridge RNA-guided recombination. Nature, 630, 2024
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8WT7
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![BU of 8wt7 by Molmil](/molmil-images/mine/8wt7) | Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, donor DNA, and target DNA in the pre-strand exchange locked state | 分子名称: | IS621 transposase, MAGNESIUM ION, bridge RNA, ... | 著者 | Hiraizumi, M, Yamashita, K, Nishimasu, H. | 登録日 | 2023-10-18 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mechanism of bridge RNA-guided recombination. Nature, 630, 2024
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8WT6
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![BU of 8wt6 by Molmil](/molmil-images/mine/8wt6) | Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, donor DNA, and target DNA in the pre-strand exchange state | 分子名称: | IS621 transposase, MAGNESIUM ION, bridge RNA, ... | 著者 | Hiraizumi, M, Yamashita, K, Nishimasu, H. | 登録日 | 2023-10-18 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural mechanism of bridge RNA-guided recombination. Nature, 630, 2024
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8WT5
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![BU of 8wt5 by Molmil](/molmil-images/mine/8wt5) | |
8WT4
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![BU of 8wt4 by Molmil](/molmil-images/mine/8wt4) | |
8WT3
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![BU of 8wt3 by Molmil](/molmil-images/mine/8wt3) | |
8WT1
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![BU of 8wt1 by Molmil](/molmil-images/mine/8wt1) | Crystal structure of S9 carboxypeptidase from Geobacillus sterothermophilus | 分子名称: | ALANINE, CITRATE ANION, GLYCEROL, ... | 著者 | Chandravanshi, K, Kumar, A, Sen, C, Singh, R, Bhange, G.B, Makde, R.D. | 登録日 | 2023-10-17 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure and solution scattering of Geobacillus stearothermophilus S9 peptidase reveal structural adaptations for carboxypeptidase activity. Febs Lett., 598, 2024
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8WSW
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![BU of 8wsw by Molmil](/molmil-images/mine/8wsw) | The Crystal Structure of LIMK2a from Biortus | 分子名称: | 1,2-ETHANEDIOL, LIM domain kinase 2, ~{N}-[5-[2-[2,6-bis(chloranyl)phenyl]-5-[bis(fluoranyl)methyl]pyrazol-3-yl]-1,3-thiazol-2-yl]-2-methyl-propanamide | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Pan, W. | 登録日 | 2023-10-17 | 公開日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The Crystal Structure of LIMK2a from Biortus. To Be Published
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8WSU
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![BU of 8wsu by Molmil](/molmil-images/mine/8wsu) | Crystal structure of SFTSV Gc and antibody | 分子名称: | Ab-H, Ab-L, Glycoprotein C | 著者 | Chang, Z, Gao, F, Wu, Y. | 登録日 | 2023-10-17 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model. Proc.Natl.Acad.Sci.USA, 121, 2024
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8WST
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![BU of 8wst by Molmil](/molmil-images/mine/8wst) | Cryo-EM structure of Melanin-Concentrating Hormone Receptor 2 with MCH | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha-1, ... | 著者 | Zhao, L, He, Q, Yuan, Q, Gu, Y, Shan, H, Hu, W, Wu, K, Xu, H.E, Zhang, Y, Wu, C. | 登録日 | 2023-10-17 | 公開日 | 2024-06-19 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors. Cell Discov, 10, 2024
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8WSS
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![BU of 8wss by Molmil](/molmil-images/mine/8wss) | Cryo-EM structure of Melanin-Concentrating Hormone Receptor 1 with MCH | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Zhao, L, He, Q, Yuan, Q, Gu, Y, Shan, H, Hu, W, Wu, K, Xu, H.E, Zhang, Y, Wu, C. | 登録日 | 2023-10-17 | 公開日 | 2024-06-19 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors. Cell Discov, 10, 2024
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8WSQ
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8WSP
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![BU of 8wsp by Molmil](/molmil-images/mine/8wsp) | Crystal structure of SFTSV Gn and antibody SF5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab5-H, Ab5-L, ... | 著者 | Chang, Z, Gao, F, Wu, Y. | 登録日 | 2023-10-17 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model. Proc.Natl.Acad.Sci.USA, 121, 2024
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8WSN
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![BU of 8wsn by Molmil](/molmil-images/mine/8wsn) | Crystal structure of SFTSV Gn and antibody SF1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab1-H, ... | 著者 | Chang, Z, Gao, F, Wu, Y. | 登録日 | 2023-10-17 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model. Proc.Natl.Acad.Sci.USA, 121, 2024
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