8WTR
HUMAN SQUALENE SYNTHASE IN COMPLEX WITH (1S,3R)-3-[2-Chloro-5-(2,2-dimethyl-propyl)-13-(2-methoxy-phenyl)-6,8-dioxo-5,6,7,8,10,11-hexahydro-13H-12-oxa-5,9-diaza-benzocycloundecen-9-yl]-cyclohexanecarboxylic acid
Summary for 8WTR
| Entry DOI | 10.2210/pdb8wtr/pdb |
| Descriptor | Squalene synthase, PHOSPHATE ION, (1~{S},3~{R})-3-[(10~{S})-13-chloranyl-2-(2,2-dimethylpropyl)-10-(2-methoxyphenyl)-3,5-bis(oxidanylidene)-9-oxa-2,6-diazabicyclo[9.4.0]pentadeca-1(15),11,13-trien-6-yl]cyclohexane-1-carboxylic acid, ... (4 entities in total) |
| Functional Keywords | terpenoid synthase fold, isoprene biosynthesis, lipid synthesis, multifunctional enzyme, oxidoreductase, steroid biosynthesis, sterol biosynthesis, transferase-transferase inhibitor complex, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 39832.77 |
| Authors | Suzuki, M.,Haginoya, N.,Suzuki, M.,Ishigai, Y.,Terayama, K.,Kanda, A.,Sugita, K. (deposition date: 2023-10-19, release date: 2024-05-22) |
| Primary citation | Haginoya, N.,Suzuki, M.,Suzuki, M.,Ishigai, Y.,Terayama, K.,Kanda, A.,Sugita, K. Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors. J.Med.Chem., 67:5305-5314, 2024 Cited by PubMed Abstract: Squalene synthase is one of the most promising pharmaceutical targets to treat hyperlipidemia. Inhibition of the squalene synthase causes a decrease in the hepatic cholesterol concentration. We have already reported the design and synthesis of highly potent benzhydrol-type squalene inhibitors. Although these templates showed unique and potent cyclic active conformations via intramolecular hydrogen bonds, the cholesterol-lowering efficacy was insufficient. We attempted to improve their potential as an orally active medicine. In our medicinal chemistry effort, cyclized 11-membered ring templates were acquired. The novel series of compounds exhibited potent squalene synthase inhibitory activity, and one of the derivatives, -(, )-, showed plasma lipid-lowering efficacy in hamster and marmoset repeated-dose studies. Our findings provide valuable insights into the design and development of novel and unique 11-membered ring-type highly potent squalene synthase inhibitors. PubMed: 38517948DOI: 10.1021/acs.jmedchem.3c01500 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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