7XGP
| Human renin in complex with compound3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Renin, UNKNOWN LIGAND | 著者 | Kashima, A. | 登録日 | 2022-04-05 | 公開日 | 2022-09-07 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor. J.Med.Chem., 65, 2022
|
|
2VS2
| Neutron diffraction structure of endothiapepsin in complex with a gem- diol inhibitor. | 分子名称: | ENDOTHIAPEPSIN, N~2~-[(2R)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-{(1R)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-[(2-morpholin-4-ylethyl)amino]-4-oxobutyl}-3-(1H-imidazol-3-ium-4-yl)-L-alaninamide | 著者 | Coates, L, Tuan, H.-F, Tomanicek, S, Kovalevsky, A, Mustyakimov, M, Erskine, P, Cooper, J. | 登録日 | 2008-04-17 | 公開日 | 2008-05-27 | 最終更新日 | 2023-11-15 | 実験手法 | NEUTRON DIFFRACTION (2 Å) | 主引用文献 | The Catalytic Mechanism of an Aspartic Proteinase Explored with Neutron and X-Ray Diffraction J.Am.Chem.Soc., 130, 2008
|
|
2WBX
| Crystal structure of mouse cadherin-23 EC1 | 分子名称: | CADHERIN-23, CALCIUM ION | 著者 | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | 登録日 | 2009-03-05 | 公開日 | 2010-04-21 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural Determinants of Cadherin-23 Function in Hearing and Deafness. Neuron, 66, 2010
|
|
3O9D
| Crystal Structure of wild-type HIV-1 Protease in complex with kd19 | 分子名称: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate, ACETATE ION, PHOSPHATE ION, ... | 著者 | Schiffer, C.A, Nalam, M.N.L. | 登録日 | 2010-08-04 | 公開日 | 2011-08-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem.Biol., 20, 2013
|
|
2VZ7
| Crystal structure of the YC-17-bound PikC D50N mutant | 分子名称: | 4-{[4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY}-12-ETHYL-3,5,7,11-TETRAMETHYLOXACYCLODODEC-9-ENE-2,8-DIONE, CYTOCHROME P450 MONOOXYGENASE, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Li, S, Sherman, D.H, Podust, L.M. | 登録日 | 2008-07-30 | 公開日 | 2008-08-12 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Analysis of Transient and Catalytic Desosamine Binding Pockets in Cytochrome P450 Pikc from Streptomyces Venezuelae. J.Biol.Chem., 284, 2009
|
|
2VRP
| Structure of rhodocytin | 分子名称: | AGGRETIN ALPHA CHAIN, AGGRETIN BETA CHAIN, CHLORIDE ION, ... | 著者 | Watson, A.A, O'Callaghan, C.A. | 登録日 | 2008-04-09 | 公開日 | 2008-07-08 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Crystal Structure of Rhodocytin, a Ligand for the Platelet-Activating Receptor Clec-2. Protein Sci., 17, 2008
|
|
2W5L
| RNASE A-NADP COMPLEX | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, RIBONUCLEASE PANCREATIC | 著者 | Chavali, G.B, Holloway, D.E, Baker, M.D, Acharya, K.R. | 登録日 | 2008-12-10 | 公開日 | 2009-02-17 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Influence of Naturally-Occurring 5'-Pyrophosphate-Linked Substituents on the Binding of Adenylic Inhibitors to Ribonuclease A: An X-Ray Crystallographic Study. Biopolymers, 91, 2009
|
|
3OFT
| Crystal Structure of Cytochrome P450 CYP101C1 | 分子名称: | (2R,5R)-hexane-2,5-diol, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Zhou, W, Ma, M, Bell, S.G, Yang, W, Hao, Y, Rees, N.H, Bartlam, M, Wong, L.-L, Rao, Z. | 登録日 | 2010-08-16 | 公開日 | 2011-07-20 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444. Chembiochem, 12, 2011
|
|
3OFU
| Crystal Structure of Cytochrome P450 CYP101C1 | 分子名称: | (3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Zhou, W, Ma, M, Bell, S.G, Yang, W, Hao, Y, Rees, N.H, Bartlam, M, Wong, L.-L, Rao, Z. | 登録日 | 2010-08-16 | 公開日 | 2011-05-04 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444. Chembiochem, 12, 2011
|
|
7XJG
| Cryo-EM structure of E.coli retron-Ec86 in complex with its effector at 2.5 angstrom | 分子名称: | DNA (105-MER), MAGNESIUM ION, RNA (14-MER), ... | 著者 | Wang, Y.J, Guan, Z.Y, Zou, T.T. | 登録日 | 2022-04-17 | 公開日 | 2022-09-14 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | 主引用文献 | Cryo-EM structures of Escherichia coli Ec86 retron complexes reveal architecture and defence mechanism. Nat Microbiol, 7, 2022
|
|
7X38
| Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb 8A10 (CVB1-E:8A10) | 分子名称: | 8A10 heavy chain, 8A10 light chain, VP2, ... | 著者 | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | 登録日 | 2022-02-28 | 公開日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
|
|
7X3F
| Cryo-EM structure of Coxsackievirus B1 A-particle in complex with nAb 9A3 (CVB1-A:9A3) | 分子名称: | 9A3 heavy chain, 9A3 light chain, VP2, ... | 著者 | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | 登録日 | 2022-02-28 | 公開日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
|
|
2VR8
| Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.36 A resolution | 分子名称: | COPPER (II) ION, SULFATE ION, SUPEROXIDE DISMUTASE [CU-ZN], ... | 著者 | Antonyuk, S, Cao, X, Seetharaman, S.V, Whitson, L.J, Taylor, A.B, Holloway, S.P, Strange, R.W, Doucette, P.A, Tiwari, A, Hayward, L.J, Padua, S, Cohlberg, J.A, Selverstone Valentine, J, Hasnain, S.S, Hart, P.J. | 登録日 | 2008-03-28 | 公開日 | 2008-04-08 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Structures of the G85R Variant of Sod1 in Familial Amyotrophic Lateral Sclerosis. J.Biol.Chem., 283, 2008
|
|
2VYY
| Mutant Ala55Trp of Cerebratuls lacteus mini-hemoglobin | 分子名称: | GLYCEROL, NEURAL HEMOGLOBIN, OXYGEN MOLECULE, ... | 著者 | Salter, M.D, Nienhaus, K, Nienhaus, G.U, Dewilde, S, Moens, L, Pesce, A, Nardini, M, Bolognesi, M, Olson, J.S. | 登録日 | 2008-07-29 | 公開日 | 2008-10-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The Apolar Channel in Cerebratulus Lacteus Hemoglobin is the Route for O2 Entry and Exit. J.Biol.Chem., 283, 2008
|
|
7X2G
| Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb nAb 2E6 (CVB1-E:2E6) | 分子名称: | 2E6 heavy chain, 2E6 light chain, VP2, ... | 著者 | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | 登録日 | 2022-02-25 | 公開日 | 2022-09-28 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
|
|
3OGQ
| Crystal Structure of 6s-98S FIV Protease with Lopinavir bound | 分子名称: | DIMETHYL SULFOXIDE, FIV protease, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE | 著者 | Lin, Y.-C, Perryman, A.L, Elder, J.H, Stout, C.D. | 登録日 | 2010-08-17 | 公開日 | 2011-06-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease. Acta Crystallogr.,Sect.D, 67, 2011
|
|
7X37
| Cryo-EM structure of Coxsackievirus B1 A particle in complex with nAb 2E6 (CVB1-A:2E6) | 分子名称: | 2E6 heavy chain, 2E6 light chain, VP2, ... | 著者 | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | 登録日 | 2022-02-28 | 公開日 | 2022-09-28 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
|
|
3OHH
| Crystal structure of beta-site app-cleaving enzyme 1 (bace-wt) complex with bms-681889 aka n~1~-butyl-5-cyano- n~3~-((1s,2r)-1-(3,5-difluorobenzyl)-2-hydroxy-3-((3- methoxybenzyl)amino)propyl)-n~1~-methyl-1h-indole-1,3- dicarboxamide | 分子名称: | Beta-secretase 1, GLYCEROL, N~1~-butyl-5-cyano-N~3~-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N~1~-methyl-1H-indole-1,3-dicarboxamide, ... | 著者 | Muckelbauer, J.K. | 登録日 | 2010-08-17 | 公開日 | 2011-04-06 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1. Bioorg.Med.Chem.Lett., 21, 2011
|
|
3ODF
| Comparison of the character and the speed of X-ray-induced structural changes of porcine pancreatic elastase at two temperatures, 100 and 15K. The data set was collected from region A of the crystal. Second step of radiation damage | 分子名称: | Chymotrypsin-like elastase family member 1, SODIUM ION, SULFATE ION | 著者 | Petrova, T, Ginell, S, Mitschler, A, Cousido-Siah, A, Hazemann, I, Podjarny, A, Joachimiak, A. | 登録日 | 2010-08-11 | 公開日 | 2010-08-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | X-ray-induced deterioration of disulfide bridges at atomic resolution. Acta Crystallogr.,Sect.D, 66, 2010
|
|
7X4K
| Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb 9A3 (classified from CVB1 mature virion in complex with 8A10 and 9A3) | 分子名称: | 9A3 heavy chain, 9A3 light chain, Genome polyprotein, ... | 著者 | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | 登録日 | 2022-03-02 | 公開日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.82 Å) | 主引用文献 | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
|
|
3OF1
| Crystal Structure of Bcy1, the Yeast Regulatory Subunit of PKA | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase regulatory subunit | 著者 | Rinaldi, J, Wu, J, Yang, J, Ralston, C.Y, Sankaran, B, Moreno, S, Taylor, S.S. | 登録日 | 2010-08-13 | 公開日 | 2010-12-01 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Structure of Yeast Regulatory Subunit: A Glimpse into the Evolution of PKA Signaling. Structure, 18, 2010
|
|
7X46
| Cryo-EM structure of Coxsackievirus B1 A-particle in complex with nAb 2E6 (classified from CVB1 mature virion in complex with 8A10 and 2E6) | 分子名称: | 2E6 heavy chain, 2E6 light chain, VP2, ... | 著者 | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | 登録日 | 2022-03-02 | 公開日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | 主引用文献 | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
|
|
7X47
| Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb 2E6 (classified from CVB1 mature virion in complex with 8A10 and 2E6) | 分子名称: | 2E6 heavy chain, 2E6 light chain, Genome polyprotein, ... | 著者 | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | 登録日 | 2022-03-02 | 公開日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
|
|
3OGB
| |
2W2X
| Complex of Rac2 and PLCg2 spPH Domain | 分子名称: | 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, ... | 著者 | Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H. | 登録日 | 2008-11-04 | 公開日 | 2009-05-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Mol.Cell, 34, 2009
|
|