7XGP

Human renin in complex with compound3

Summary for 7XGP

• Entry DOI: 10.2210/pdb7xgp/pdb
• Descriptor: Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, UNKNOWN LIGAND (3 entities in total)
• Functional Keywords: hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 74976.43

Authors

Kashima, A. (deposition date: 2022-04-05, release date: 2022-09-07)

• Primary citation: Iijima, D.,Sugama, H.,Takahashi, Y.,Hirai, M.,Togashi, Y.,Xie, J.,Shen, J.,Ke, Y.,Akatsuka, H.,Kawaguchi, T.,Takedomi, K.,Kashima, A.,Nishio, M.,Inui, Y.,Yoneda, H.,Xia, G.,Iijima, T.; Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor.; J.Med.Chem., 65:10882-10897, 2022; PubMed: 35939295; DOI: 10.1021/acs.jmedchem.2c00834

Experimental method

X-RAY DIFFRACTION (2.65 Å)