PDB: 1833 件ウェブページステータス検索Chemie searchBIRD

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8F8M	LRH-1 bound to small molecule Tet and fragment of coactivator Tif2 分子名称: (1~{R},3~{a}~{R},6~{a}~{R})-4-phenyl-3~{a}-(1-phenylethenyl)-5-[9-(1~{H}-1,2,3,4-tetrazol-5-yl)nonyl]-2,3,6,6~{a}-tetrahydro-1~{H}-pentalen-1-ol, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2 著者 Cato, M.L, Ortlund, E.A. 登録日 2022-11-22 公開日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Isosteric improvements to liver receptor homolog-1 small molecule modulators To Be Published
8FAV	HUMAN RETENOID-RELATED ORPHAN RECEPTOR-GAMMA (RORC2) LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 5 ANDINDAZOLE ACID BOUND IN H12-POCKET 分子名称: 3-cyano-N-(3-{[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl}-5-fluoro-2-methylphenyl)benzamide, 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoro-1H-indazol-3-yl}-3-fluorobenzoic acid, Nuclear receptor ROR-gamma, ... 著者 Vajdos, F.F. 登録日 2022-11-28 公開日 2023-03-01 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists. Acs Med.Chem.Lett., 14, 2023
8FB1	HUMAN RETENOID-RELATED ORPHAN RECEPTOR-GAMMA (RORC2) LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 6a ANDINDAZOLE ACID BOUND IN H12-POCKET 分子名称: 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoro-1H-indazol-3-yl}-3-fluorobenzoic acid, N-(3-{[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl}-5-fluoro-2-methylphenyl)-4-fluorobenzene-1-sulfonamide, Nuclear receptor ROR-gamma 著者 Vajdos, F.F. 登録日 2022-11-29 公開日 2023-03-01 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists. Acs Med.Chem.Lett., 14, 2023
8FB2	HUMAN RETENOID-RELATED ORPHAN RECEPTOR-GAMMA (RORC2) LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 8 ANDINDAZOLE ACID BOUND IN H12-POCKET 分子名称: (1R,15S)-16-(cyclopropylacetyl)-5-fluoro-20-methyl-9lambda~6~-thia-1,8,16-triazatricyclo[13.3.1.1~3,7~]icosa-3(20),4,6-triene-9,9-dione, 4-[1-(2,6-dichlorobenzoyl)-4-fluoro-1H-indazol-3-yl]benzoic acid, Nuclear receptor ROR-gamma 著者 Vajdos, F.F. 登録日 2022-11-29 公開日 2023-03-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists. Acs Med.Chem.Lett., 14, 2023
8FFW	Cryo-EM structure of the GR-Hsp90-FKBP51 complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... 著者 Noddings, C.M, Agard, D.A. 登録日 2022-12-10 公開日 2023-11-01 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
8FFV	Cryo-EM structure of the GR-Hsp90-FKBP52 complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... 著者 Noddings, C.M, Agard, D.A. 登録日 2022-12-10 公開日 2023-11-01 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
8FH2	Crystal structure of mutant Androgen Receptor ligand binding domain L702H/H875Y with DHT 分子名称: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION 著者 Doamekpor, S.K, Tong, L. 登録日 2022-12-13 公開日 2023-04-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations. Acta Crystallogr.,Sect.F, 79, 2023
8FGZ	Crystal structure of mutant Androgen Receptor ligand binding domain L702H/H875Y/F877L with DHT 分子名称: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION 著者 Doamekpor, S.K, Tong, L. 登録日 2022-12-13 公開日 2023-04-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations. Acta Crystallogr.,Sect.F, 79, 2023
8FGY	Crystal structure of mutant Androgen Receptor ligand binding domain L702H/H875Y/F877L/T878A with DHT 分子名称: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor 著者 Doamekpor, S.K, Tong, L. 登録日 2022-12-13 公開日 2023-04-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations. Acta Crystallogr.,Sect.F, 79, 2023
8FH0	Crystal structure of mutant Androgen Receptor ligand binding domain H875Y/F877L/T878A with DHT 分子名称: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION 著者 Doamekpor, S.K, Tong, L. 登録日 2022-12-13 公開日 2023-04-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations. Acta Crystallogr.,Sect.F, 79, 2023
8FH1	Crystal structure of mutant Androgen Receptor ligand binding domain F877L/T878A with DHT 分子名称: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION 著者 Doamekpor, S.K, Tong, L. 登録日 2022-12-13 公開日 2023-04-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations. Acta Crystallogr.,Sect.F, 79, 2023
8FHE	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and GW9662 分子名称: 2-chloro-5-nitro-N-phenylbenzamide, Nuclear receptor corepressor 1, Peroxisome proliferator-activated receptor gamma 著者 Shang, J, Kojetin, D.J. 登録日 2022-12-14 公開日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and GW9662 To Be Published
8FHG	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and ZINC5672437 分子名称: N-(4-carbamoylphenyl)-2-chloro-5-nitrobenzamide, Nuclear receptor corepressor 1, Peroxisome proliferator-activated receptor gamma 著者 Shang, J, Kojetin, D.J. 登録日 2022-12-14 公開日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and ZINC5672437 To Be Published
8FHF	Crystal structure of PPARgamma ligand-binding domain in complex with ZINC5672437 分子名称: N-(4-carbamoylphenyl)-2-chloro-5-nitrobenzamide, Peroxisome proliferator-activated receptor gamma, nonanoic acid 著者 Shang, J, Kojetin, D.J. 登録日 2022-12-14 公開日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of PPARgamma ligand-binding domain in complex with ZINC5672437 To Be Published
8C0C	X-ray crystal structure of PPAR gamma ligand binding domain in complex with CZ46 分子名称: (2~{R})-2-[4-(naphthalen-1-ylmethoxy)phenyl]-4-oxidanyl-3-phenyl-2~{H}-furan-5-one, Peroxisome proliferator-activated receptor gamma 著者 Capelli, D, Montanari, R, Pochetti, G, Villa, S, Meneghetti, F. 登録日 2022-12-16 公開日 2023-04-26 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Biological Screening and Crystallographic Studies of Hydroxy gamma-Lactone Derivatives to Investigate PPAR gamma Phosphorylation Inhibition. Biomolecules, 13, 2023
8C1L	Crystal structure of HNF4 alpha LBD in complexes with palmitic acid and GRIP-1 peptide 分子名称: 1,2-ETHANEDIOL, Hepatocyte nuclear factor 4-alpha, Nuclear receptor coactivator 2, ... 著者 Ni, X, Merk, D, Zhubi, R, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2022-12-20 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of HNF4 alpha LBD in complexes with palmitic acid and GRIP-1 peptide To Be Published
8FKF	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse agonist SR36706 分子名称: 1,2-ETHANEDIOL, 2-chloro-N-(5-fluoropyridin-3-yl)-5-nitrobenzamide, GLYCEROL, ... 著者 MacTavish, B.S, Kojetin, D.J. 登録日 2022-12-21 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR36706 To Be Published
8FKD	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse agonist SR33068 分子名称: 1,2-ETHANEDIOL, 2-chloro-N-(6-cyanopyridin-3-yl)-5-nitrobenzamide, Nuclear receptor corepressor 1, ... 著者 MacTavish, B.S, Kojetin, D.J. 登録日 2022-12-21 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR33068 To Be Published
8FKG	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse agonist SR33486 分子名称: 1,2-ETHANEDIOL, 2-chloro-N-(5-cyanopyridin-2-yl)-5-nitrobenzamide, GLYCEROL, ... 著者 MacTavish, B.S, Kojetin, D.J. 登録日 2022-12-21 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR33486 To Be Published
8FKC	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse agonist SR33544 分子名称: 1,2-ETHANEDIOL, 2-chloro-N-(5-cyanopyridin-3-yl)-5-nitrobenzamide, Nuclear receptor corepressor 1, ... 著者 MacTavish, B.S, Kojetin, D.J. 登録日 2022-12-21 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR33544 To Be Published
8FKE	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse agonist SR32904 分子名称: 1,2-ETHANEDIOL, 2-chloro-N-(2-methylpyridin-4-yl)-5-nitrobenzamide, Nuclear receptor corepressor 1, ... 著者 MacTavish, B.S, Kojetin, D.J. 登録日 2022-12-21 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR32904 To Be Published
8HUK	X-ray structure of human PPAR alpha ligand binding domain-lanifibranor-SRC1 coactivator peptide co-crystals obtained by soaking 分子名称: 15-meric peptide from Nuclear receptor coactivator 1, 4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl]butanoic acid, Peroxisome proliferator-activated receptor alpha 著者 Kamata, S, Ishikawa, R, Akahane, M, Honda, A, Oyama, T, Ishii, I. 登録日 2022-12-24 公開日 2023-08-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.981 Å) 主引用文献 Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants, 12, 2023
8HUL	X-ray structure of human PPAR delta ligand binding domain-lanifibranor co-crystals obtained by co-crystallization 分子名称: 4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl]butanoic acid, Peroxisome proliferator-activated receptor delta 著者 Kamata, S, Honda, A, Machida, Y, Uchii, K, Shiiyama, Y, Masuda, R, Oyama, T, Ishii, I. 登録日 2022-12-24 公開日 2023-08-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.461 Å) 主引用文献 Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants, 12, 2023
8HUQ	X-ray structure of human PPAR alpha ligand binding domain-elafibranor-SRC1 coactivator peptide co-crystals obtained by soaking 分子名称: 15-meric peptide from Nuclear receptor coactivator 1, 2-[2,6-dimethyl-4-[(~{E})-3-(4-methylsulfanylphenyl)-3-oxidanylidene-prop-1-enyl]phenoxy]-2-methyl-propanoic acid, GLYCEROL, ... 著者 Kamata, S, Ishikawa, R, Akahane, M, Honda, A, Oyama, T, Ishii, I. 登録日 2022-12-24 公開日 2023-08-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants, 12, 2023
8HUN	X-ray structure of human PPAR alpha ligand binding domain-seladelpar co-crystals obtained by cross-seeding 分子名称: GLYCEROL, Peroxisome proliferator-activated receptor alpha, Seladelpar 著者 Kamata, S, Honda, A, Machida, Y, Uchii, K, Shiiyama, Y, Masuda, R, Iino, S, Oyama, T, Ishii, I. 登録日 2022-12-24 公開日 2023-08-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants, 12, 2023

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