PDB: 2074 件ウェブページステータス検索Chemie searchBIRD

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7JPY	Crystal structure of the SARS-CoV-2 main protease in its apo-form 分子名称: 3C-like proteinase 著者 Yang, K, Liu, W. 登録日 2020-08-10 公開日 2020-12-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors*. Chemmedchem, 16, 2021
7JQ4	Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI7 分子名称: 3C-like proteinase, N-[(benzyloxy)carbonyl]-O-tert-butyl-L-threonyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide 著者 Yang, K, Liu, W. 登録日 2020-08-10 公開日 2020-12-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors*. Chemmedchem, 16, 2021
7JQ0	Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI3 分子名称: 3C-like proteinase, N-[(benzyloxy)carbonyl]-L-valyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide 著者 Yang, K, Liu, W. 登録日 2020-08-10 公開日 2020-12-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors*. Chemmedchem, 16, 2021
7JQB	SARS-CoV-2 Nsp1 and rabbit 40S ribosome complex 分子名称: 40S ribosomal protein S21, 40S ribosomal protein S24, 40S ribosomal protein S26, ... 著者 Yuan, S, Xiong, Y. 登録日 2020-08-10 公開日 2020-12-02 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA. Mol.Cell, 80, 2020
7JQ3	Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI6 分子名称: 3C-like proteinase, N-[(benzyloxy)carbonyl]-O-tert-butyl-L-threonyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide 著者 Yang, K, Liu, W. 登録日 2020-08-10 公開日 2020-12-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors*. Chemmedchem, 16, 2021
7JQ1	Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI4 分子名称: 3C-like proteinase, N-[(benzyloxy)carbonyl]-L-valyl-N-{(2S)-1-hydroxy-3-[(3R)-2-oxo-3,4-dihydro-2H-pyrrol-3-yl]propan-2-yl}-L-phenylalaninamide 著者 Yang, K, Liu, W. 登録日 2020-08-10 公開日 2020-12-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors*. Chemmedchem, 16, 2021
7JPZ	Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI1 分子名称: (phenylmethyl) N-[(2S)-1-oxidanylidene-1-[[(2S)-1-oxidanyl-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-3-phenyl-propan-2-yl]carbamate, 3C-like proteinase 著者 Yang, K, Liu, W. 登録日 2020-08-10 公開日 2020-12-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors*. Chemmedchem, 16, 2021
7JQ5	Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI8 分子名称: 3C-like proteinase, N-[(BENZYLOXY)CARBONYL]-O-(TERT-BUTYL)-L-THREONYL-3-CYCLOHEXYL-N-[(1S)-2-HYDROXY-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}ETHYL]-L-ALANINAMIDE 著者 Yang, K, Liu, W. 登録日 2020-08-10 公開日 2020-12-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors*. Chemmedchem, 16, 2021
7JOY	Product structure of SARS-CoV-2 Mpro C145A mutant in complex with its C-terminal autoprocessing sequence. 分子名称: 3C-like proteinase 著者 Lee, J, Worrall, L.J, Paetzel, M, Strynadka, N.C.J. 登録日 2020-08-07 公開日 2020-10-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site. Nat Commun, 11, 2020
7JP1	Structure of wild-type substrate free SARS-CoV-2 Mpro. 分子名称: 3C-like proteinase 著者 Lee, J, Worrall, L.J, Paetzel, M, Strynadka, N.C.J. 登録日 2020-08-07 公開日 2020-10-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site. Nat Commun, 11, 2020
7JP0	Crystal structure of Mpro with inhibitor r1 分子名称: 3C-like proteinase, DIMETHYL SULFOXIDE, N-[(benzyloxy)carbonyl]-L-valyl-N-{(2R)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide 著者 Yang, K, Liu, W. 登録日 2020-08-07 公開日 2021-10-13 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of Mpro with inhibitor r1 To Be Published
7COT	Structure of post fusion core of SARS-CoV-2 S2 subunit 分子名称: Spike glycoprotein 著者 Lin, M.H, Tan, K.P, Hsu, C.H. 登録日 2020-08-05 公開日 2021-08-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Crystal structure of post fusion core of SARS-CoV-2 S2 subunit To Be Published
7COM	Crystal structure of the SARS-CoV-2 main protease in complex with Boceprevir (space group P212121) 分子名称: 3C-like proteinase, boceprevir (bound form) 著者 Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Liu, J.M, Zhou, Y.L, Chen, P, Yang, S.Y, Lei, J. 登録日 2020-08-04 公開日 2020-08-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model. Science, 371, 2021
7JMX	Crystal structure of a SARS-CoV-2 cross-neutralizing antibody COVA1-16 Fab 分子名称: ACETATE ION, COVA1-16 heavy chain, COVA1-16 light chain, ... 著者 Liu, H, Yuan, M, Zhu, X, Wu, N.C, Wilson, I.A. 登録日 2020-08-03 公開日 2020-10-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity. Immunity, 53, 2020
7JMW	Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with cross-neutralizing antibody COVA1-16 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVA1-16 heavy chain, COVA1-16 light chain, ... 著者 Liu, H, Yuan, M, Zhu, X, Wu, N.C, Wilson, I.A. 登録日 2020-08-03 公開日 2020-10-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity. Immunity, 53, 2020
7JN2	The crystal structure of Papain-Like Protease of SARS CoV-2 in complex with PLP_Snyder441 inhibitor 分子名称: 3-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ACETATE ION, CHLORIDE ION, ... 著者 Osipiuk, J, Tesar, C, Endres, M, Lisnyak, V, Maki, S, Taylor, C, Zhang, Y, Zhou, Z, Azizi, S.A, Jones, K, Kathayat, R, Snyder, S.A, Dickinson, B.C, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2020-08-03 公開日 2020-08-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 The crystal structure of Papain-Like Protease of SARS CoV-2 in complex with PLP_Snyder441 to be published
7JMO	Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-04 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, COVA2-04 heavy chain, COVA2-04 light chain, ... 著者 Wu, N.C, Yuan, M, Liu, H, Zhu, X, Wilson, I.A. 登録日 2020-08-02 公開日 2020-08-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.359 Å) 主引用文献 An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain. Cell Rep, 33, 2020
7JMP	Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-39 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, COVA2-39 heavy chain, COVA2-39 light chain, ... 著者 Wu, N.C, Yuan, M, Liu, H, Zhu, X, Wilson, I.A. 登録日 2020-08-02 公開日 2020-08-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.712 Å) 主引用文献 An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain. Cell Rep, 33, 2020
7JME	Structure of the SARS-CoV-2 NSP3 Macro X domain in complex with cyclic AMP 分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Non-structural protein 3 著者 Vuksanovic, N, Melkonian, T.R, Silvaggi, N.R. 登録日 2020-07-31 公開日 2020-09-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3. Slas Discov, 25, 2020
7CN9	Cryo-EM structure of SARS-CoV-2 Spike ectodomain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Ho, M, Chang, Y, Wang, C, Wu, Y, Huang, H, Chen, T, Lo, J.M, Chen, X, Ma, C. 登録日 2020-07-30 公開日 2020-08-26 最終更新日 2021-03-10 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2. Cell Rep, 32, 2020
6ZXN	Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing nanobodies (Ty1) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Ty1, ... 著者 Hallberg, B.M, Das, H. 登録日 2020-07-30 公開日 2020-09-23 実験手法 ELECTRON MICROSCOPY (2.93 Å) 主引用文献 An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction. Nat Commun, 11, 2020
7CMD	Crystal structure of the SARS-CoV-2 PLpro with GRL0617 分子名称: 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, Non-structural protein 3, ZINC ION 著者 Gao, X, Cui, S. 登録日 2020-07-27 公開日 2020-09-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Crystal structure of SARS-CoV-2 papain-like protease. Acta Pharm Sin B, 11, 2021
7JJI	Structure of SARS-CoV-2 3Q-2P full-length prefusion spike trimer (C3 symmetry) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-hydroxyethyl 2-deoxy-3,5-bis-O-(2-hydroxyethyl)-6-O-(2-{[(9E)-octadec-9-enoyl]oxy}ethyl)-alpha-L-xylo-hexofuranoside, ... 著者 Bangaru, S, Turner, H.L, Ozorowski, G, Antanasijevic, A, Ward, A.B. 登録日 2020-07-26 公開日 2020-08-26 最終更新日 2020-12-23 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate. Science, 370, 2020
7JJJ	Structure of SARS-CoV-2 3Q-2P full-length dimers of spike trimers 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Bangaru, S, Turner, H.L, Ozorowski, G, Antanasijevic, A, Ward, A.B. 登録日 2020-07-26 公開日 2020-08-26 最終更新日 2020-12-23 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate. Science, 370, 2020
7JJC	Crystal structure of neuropilin-1 b1 domain in complex with SARS-CoV-2 S1 C-end rule (CendR) peptide 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Neuropilin-1, ... 著者 Chen, K.-E, Collins, B.M. 登録日 2020-07-25 公開日 2020-10-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science, 370, 2020

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