3MUN
| APPEP_PEPCLOSE closed state | 分子名称: | GLYCEROL, Prolyl endopeptidase, SULFATE ION, ... | 著者 | Chiu, T.K. | 登録日 | 2010-05-03 | 公開日 | 2011-05-18 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Route of Substrate Entry in Prolyl Endopeptidase TO BE PUBLISHED
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3MUO
| APPEP_PEPCLOSE+PP closed state | 分子名称: | GLYCEROL, N-BENZYLOXYCARBONYL-L-PROLYL-L-PROLINAL, Prolyl endopeptidase, ... | 著者 | Chiu, T.K. | 登録日 | 2010-05-03 | 公開日 | 2011-06-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Route of Substrate Entry in Prolyl Endopeptidase TO BE PUBLISHED
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3OBV
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3OVN
| Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase | 分子名称: | 1-methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine, CADMIUM ION, POL polyprotein, ... | 著者 | Wielens, J, Chalmers, D.K, Headey, S.J, Deadman, J.J, Rhodes, D.K, Parker, M.W, Scanlon, M.J. | 登録日 | 2010-09-16 | 公開日 | 2011-03-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6, 2011
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3Q73
| Cryptococcus neoformans protein farnesyltransferase, apo enzyme | 分子名称: | (2S)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, Farnesyltransferase, alpha subunit, ... | 著者 | Hast, M.A, Beese, L.S. | 登録日 | 2011-01-04 | 公開日 | 2011-08-03 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens. J.Biol.Chem., 286, 2011
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3Q7A
| Cryptococcus neoformans protein farnesyltransferase in complex with FPP and L-778,123 | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE, FARNESYL DIPHOSPHATE, ... | 著者 | Hast, M.A, Beese, L.S. | 登録日 | 2011-01-04 | 公開日 | 2011-08-03 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens. J.Biol.Chem., 286, 2011
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3Q7F
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3QGV
| Crystal structure of a thermostable amylase variant | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha amylase, CALCIUM ION, ... | 著者 | Hein, K.L, Ganshaw, G, Bott, R, Nissen, P. | 登録日 | 2011-01-25 | 公開日 | 2012-02-01 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of a highly mutated, thermostable \xCE\xB1-amylase variant To be Published
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3QPH
| The three-dimensional structure of TrmB, a global transcriptional regulator of the hyperthermophilic archaeon Pyrococcus furiosus in complex with sucrose | 分子名称: | ACETATE ION, GLYCEROL, TrmB, ... | 著者 | Krug, M, Lee, S.-J, Boos, W, Welte, W, Diederichs, K. | 登録日 | 2011-02-13 | 公開日 | 2012-05-30 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.992 Å) | 主引用文献 | The three-dimensional structure of TrmB, a transcriptional regulator of dual function in the hyperthermophilic archaeon Pyrococcus furiosus in complex with sucrose. Protein Sci., 22, 2013
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3QYQ
| 1.8 Angstrom resolution crystal structure of a putative deoxyribose-phosphate aldolase from Toxoplasma gondii ME49 | 分子名称: | Deoxyribose-phosphate aldolase, putative, SULFATE ION, ... | 著者 | Halavaty, A.S, Ruan, J, Minasov, G, Shuvalova, L, Ueno, A, Igarashi, M, Ngo, H, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2011-03-03 | 公開日 | 2011-03-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and functional divergence of the aldolase fold in Toxoplasma gondii. J.Mol.Biol., 427, 2015
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3R1B
| Open crystal structure of cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene | 分子名称: | (4-tert-butylphenyl)acetaldehyde, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, Cytochrome P450 2B4, ... | 著者 | Gay, S.C, Zhang, H, Stout, C.D, Hollenberg, P.F, Halpert, J.R. | 登録日 | 2011-03-09 | 公開日 | 2011-05-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity. Biochemistry, 50, 2011
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3S7Z
| Crystal Structure of Putative Aspartate Racemase from Salmonella Typhimurium Complexed with Succinate | 分子名称: | MAGNESIUM ION, Putative aspartate racemase, SUCCINIC ACID, ... | 著者 | Maltseva, N, Zhang, R, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2011-05-27 | 公開日 | 2011-10-05 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | 主引用文献 | Crystal Structure of Putative Aspartate Racemase from Salmonella Typhimurium Complexed with Succinate. To be Published
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3SO3
| Structures of Fab-Protease Complexes Reveal a Highly Specific Non-Canonical Mechanism of Inhibition. | 分子名称: | A11 FAB heavy chain, A11 FAB light chain, GLYCEROL, ... | 著者 | Schneider, E.L, Farady, C.J, Egea, P.F, Goetz, D.H, Baharuddin, A, Craik, C.S. | 登録日 | 2011-06-29 | 公開日 | 2012-06-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A reverse binding motif that contributes to specific protease inhibition by antibodies. J.Mol.Biol., 415, 2012
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3SP3
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3T3Z
| Human Cytochrome P450 2E1 in complex with pilocarpine | 分子名称: | (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one, Cytochrome P450 2E1, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Meneely, K.M, DeVore, N.M, Scott, E.E. | 登録日 | 2011-07-25 | 公開日 | 2011-12-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine. Febs J., 279, 2012
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3T6U
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3TAN
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3TAP
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3TAQ
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3TAR
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3VF1
| Structure of a calcium-dependent 11R-lipoxygenase suggests a mechanism for Ca-regulation | 分子名称: | 11R-lipoxygenase, FE (II) ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | 著者 | Eek, P, Jarving, R, Jarving, I, Gilbert, N.C, Newcomer, M.E, Samel, N. | 登録日 | 2012-01-09 | 公開日 | 2012-05-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.473 Å) | 主引用文献 | Structure of a Calcium-dependent 11R-Lipoxygenase Suggests a Mechanism for Ca2+ Regulation. J.Biol.Chem., 287, 2012
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3VQ7
| HIV-1 IN core domain in complex with 4-(1H-pyrrol-1-yl)aniline | 分子名称: | 4-(1H-pyrrol-1-yl)aniline, CADMIUM ION, POL polyprotein, ... | 著者 | Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. | 登録日 | 2012-03-20 | 公開日 | 2013-01-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
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3VQA
| HIV-1 IN core domain in complex with 1-benzothiophen-6-amine 1,1-dioxide | 分子名称: | 1-benzothiophen-6-amine 1,1-dioxide, CADMIUM ION, POL polyprotein, ... | 著者 | Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. | 登録日 | 2012-03-20 | 公開日 | 2013-01-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
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3VQQ
| HIV-1 integrase core domain in complex with 2,1,3-benzothiadiazol-4-amine | 分子名称: | 2,1,3-benzothiadiazol-4-amine, CADMIUM ION, POL polyprotein, ... | 著者 | Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. | 登録日 | 2012-03-29 | 公開日 | 2013-01-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
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4B9L
| Structure of the high fidelity DNA polymerase I with the oxidative formamidopyrimidine-dA DNA lesion in the pre-insertion site. | 分子名称: | 5'-D(*CP*AP*GP*FAX*AP*GP*AP*GP*TP*CP*AP*GP*GP*CP*TP)-3', 5'-D(*GP*CP*CP*TP*GP*AP*CP*TP*CP*TP)-3', DNA POLYMERASE I, ... | 著者 | Gehrke, T.H, Lischke, U, Arnold, S, Schneider, S, Carell, T. | 登録日 | 2012-09-05 | 公開日 | 2013-04-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Unexpected Non-Hoogsteen-Based Mutagenicity Mechanism of Fapy-DNA Lesions. Nat.Chem.Biol., 9, 2013
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