3SO3
Structures of Fab-Protease Complexes Reveal a Highly Specific Non-Canonical Mechanism of Inhibition.
Summary for 3SO3
| Entry DOI | 10.2210/pdb3so3/pdb |
| Related | 3BN9 |
| Related PRD ID | PRD_900003 |
| Descriptor | Suppressor of tumorigenicity 14 protein, A11 FAB light chain, A11 FAB heavy chain, ... (6 entities in total) |
| Functional Keywords | antibody-protein, protein-protein, protease inhibitor, disease mutation, glycoprotein, hydrolase, membrane, serine protease, signal-anchor, transmembrane |
| Biological source | Homo sapiens (human) More |
| Cellular location | Membrane; Single-pass type II membrane protein (Probable): Q9Y5Y6 |
| Total number of polymer chains | 3 |
| Total formula weight | 74331.00 |
| Authors | Schneider, E.L.,Farady, C.J.,Egea, P.F.,Goetz, D.H.,Baharuddin, A.,Craik, C.S. (deposition date: 2011-06-29, release date: 2012-06-20, Last modification date: 2023-09-13) |
| Primary citation | Schneider, E.L.,Lee, M.S.,Baharuddin, A.,Goetz, D.H.,Farady, C.J.,Ward, M.,Wang, C.I.,Craik, C.S. A reverse binding motif that contributes to specific protease inhibition by antibodies. J.Mol.Biol., 415:699-715, 2012 Cited by PubMed: 22154938DOI: 10.1016/j.jmb.2011.11.036 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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