3SO3
Structures of Fab-Protease Complexes Reveal a Highly Specific Non-Canonical Mechanism of Inhibition.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Suppressor of tumorigenicity 14 protein | polymer | 241 | 26447.7 | 1 | UniProt (Q9Y5Y6) Pfam (PF00089) | Homo sapiens (human) | Matriptase, Membrane-type serine protease 1, MT-SP1, Prostamin, Serine protease 14, Serine protease TADG-15, Tumor-associated differentially-expressed gene 15 protein |
| 2 | B (B) | A11 FAB light chain | polymer | 217 | 23627.1 | 1 | Homo sapiens (human) | ||
| 3 | C (C) | A11 FAB heavy chain | polymer | 228 | 23821.8 | 1 | Homo sapiens (human) | ||
| 4 | D (D) | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900003) | sucrose | ||
| 5 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F, G, H (A, B, C) | water | water | 18.0 | 461 | Chemie (HOH) |
Sequence modifications
A: 16 - 244 (UniProt: Q9Y5Y6)
| PDB | External Database | Details |
|---|---|---|
| Ser 122 | Cys 731 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 73896.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 342.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 74331.0 |
