PDB: 493 件ウェブページステータス検索Chemie searchBIRD

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3A0T	Catalytic domain of histidine kinase ThkA (TM1359) in complex with ADP and Mg ion (trigonal) 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Sensor protein 著者 Yamada, S, Sugimoto, H, Kobayashi, M, Ohno, A, Nakamura, H, Shiro, Y. 登録日 2009-03-24 公開日 2009-10-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Structure of PAS-linked histidine kinase and the response regulator complex Structure, 17, 2009
3A0Z	Catalytic domain of histidine kinase ThkA (TM1359) (nucleotide free form 4: isopropanol, orthorombic) 分子名称: Sensor protein 著者 Yamada, S, Sugimoto, H, Kobayashi, M, Ohno, A, Nakamura, H, Shiro, Y. 登録日 2009-03-25 公開日 2009-10-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structure of PAS-linked histidine kinase and the response regulator complex Structure, 17, 2009
3CGY	Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain in complex with radicicol 分子名称: RADICICOL, Virulence sensor histidine kinase phoQ 著者 Guarnieri, M.T, Zhang, L, Shen, J, Zhao, R. 登録日 2008-03-06 公開日 2008-05-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ. J.Mol.Biol., 379, 2008
3CGZ	Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain 分子名称: Virulence sensor histidine kinase phoQ 著者 Guarnieri, M.T, Zhang, L, Shen, J, Zhao, R. 登録日 2008-03-06 公開日 2008-05-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ. J.Mol.Biol., 379, 2008
1ZW9	Yeast HSP82 in complex with the Novel HSP90 Inhibitor 8-(6-Bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)-adenine 分子名称: 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE, HSP82 著者 Immormino, R.M, Gewirth, D.T, Chiosis, G. 登録日 2005-06-03 公開日 2006-06-13 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design To be Published
2AKP	Hsp90 Delta24-N210 mutant 分子名称: ATP-dependent molecular chaperone HSP82 著者 Richter, K, Moser, S, Hagn, F, Friedrich, R, Hainzl, O, Heller, M, Schlee, S, Kessler, H, Reinstein, J, Buchner, J. 登録日 2005-08-03 公開日 2006-01-31 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Intrinsic inhibition of the Hsp90 ATPase activity. J.Biol.Chem., 281, 2006
1AH6	STRUCTURE OF THE TETRAGONAL FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE 分子名称: HEAT SHOCK PROTEIN 90 著者 Prodromou, C, Roe, S.M, Pearl, L.H. 登録日 1997-04-14 公開日 1997-10-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone. Nat.Struct.Biol., 4, 1997
1AMW	ADP BINDING SITE IN THE HSP90 MOLECULAR CHAPERONE 分子名称: ADENOSINE-5'-DIPHOSPHATE, HEAT SHOCK PROTEIN 90 著者 Pearl, L.H, Roe, S.M, Prodromou, C. 登録日 1997-06-19 公開日 1998-06-24 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone Cell(Cambridge,Mass.), 90, 1997
1A4H	STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE IN COMPLEX WITH GELDANAMYCIN 分子名称: GELDANAMYCIN, HEAT SHOCK PROTEIN 90 著者 Prodromou, C, Roe, S.M, Pearl, L.H. 登録日 1998-01-29 公開日 1998-08-05 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone Cell(Cambridge,Mass.), 90, 1997
1YSR	Crystal Structure of ATP binding domain of PrrB from Mycobacterium Tuberculosis 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Sensor-type histidine kinase prrB 著者 Nowak, E, Panjikar, S, Tucker, P, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) 登録日 2005-02-09 公開日 2005-07-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Crystal Structure of ATP binding domain of PrrB from Mycobacterium Tuberculosis To be published
1YS3	Crystal Structure of the ATP binding domain of PrrB from Mycobacterium Tuberculosis 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Sensor-type histidine kinase prrB 著者 Nowak, E, Panjikar, S, Tucker, P, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) 登録日 2005-02-07 公開日 2005-07-12 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of ATP binding domain of Hidtidine Kinase from MTB To be Published
1AJ6	NOVOBIOCIN-RESISTANT MUTANT (R136H) OF THE N-TERMINAL 24 KDA FRAGMENT OF DNA GYRASE B COMPLEXED WITH NOVOBIOCIN AT 2.3 ANGSTROMS RESOLUTION 分子名称: GYRASE, NOVOBIOCIN 著者 Weston, S.A, Tunnicliffe, A, Pauptit, R.A. 登録日 1997-05-15 公開日 1998-05-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study. Biochemistry, 36, 1997
1ZWH	Yeast Hsp82 in complex with the novel Hsp90 inhibitor Radester amine 分子名称: 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE, ATP-dependent molecular chaperone HSP82 著者 Immormino, R.M, Blagg, B.S, Gewirth, D.T. 登録日 2005-06-03 公開日 2006-06-13 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design To be Published
1AM1	ATP BINDING SITE IN THE HSP90 MOLECULAR CHAPERONE 分子名称: ADENOSINE-5'-DIPHOSPHATE, HEAT SHOCK PROTEIN 90 著者 Pearl, L.H, Roe, S.M, Prodromou, C. 登録日 1997-06-20 公開日 1998-06-24 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone Cell(Cambridge,Mass.), 90, 1997
1AH8	STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE 分子名称: GLYCEROL, HEAT SHOCK PROTEIN 90 著者 Prodromou, C, Roe, S.M, Pearl, L.H. 登録日 1997-04-14 公開日 1997-10-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone. Nat.Struct.Biol., 4, 1997
2BRC	Structure of a Hsp90 Inhibitor bound to the N-terminus of Yeast Hsp90. 分子名称: 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 著者 Roe, S.M, Pearl, L.H, Prodromou, C. 登録日 2005-05-04 公開日 2005-09-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg. Med. Chem. Lett., 15, 2005
1BGQ	RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE 分子名称: HEAT SHOCK PROTEIN 90, RADICICOL 著者 Roe, S.M, Prodromou, C, Pearl, L.H. 登録日 1998-05-29 公開日 1999-06-08 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J.Med.Chem., 42, 1999
2BRE	STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90. 分子名称: 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 著者 Roe, S.M, Pearl, L.H, Prodromou, C. 登録日 2005-05-04 公開日 2005-09-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg. Med. Chem. Lett., 15, 2005
1BXD	NMR STRUCTURE OF THE HISTIDINE KINASE DOMAIN OF THE E. COLI OSMOSENSOR ENVZ 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PROTEIN (OSMOLARITY SENSOR PROTEIN (ENVZ)) 著者 Tanaka, T, Saha, S.K, Tomomori, C, Ishima, R, Liu, D, Tong, K.I, Park, H, Dutta, R, Qin, L, Swindells, M.B, Yamazaki, T, Ono, A.M, Kainosho, M, Inouye, M, Ikura, M. 登録日 1998-10-02 公開日 1999-10-02 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ. Nature, 396, 1998
7C7O	Crystal structure of E.coli DNA gyrase B in complex with 6-fluoro-8-(methylamino)-2-oxo-1,2-dihydroquinoline derivative 分子名称: 4-[[4-(3-azanylpropylamino)-6-fluoranyl-8-(methylamino)-2-oxidanylidene-1~{H}-quinolin-3-yl]carbonylamino]benzoic acid, DNA gyrase subunit B 著者 Kamitani, M, Mima, M, Takeuchi, T, Ushiyama, F. 登録日 2020-05-26 公開日 2020-10-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. Bioorg.Med.Chem., 28, 2020
7DOR	E. coli GyrB ATPase domain in complex with 4-nitropheno 分子名称: 1H-benzimidazol-2-amine, DNA gyrase subunit B, P-NITROPHENOL, ... 著者 Yu, Y, Zhou, H. 登録日 2020-12-16 公開日 2021-10-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Identification of new building blocks by fragment screening for discovering GyrB inhibitors. Bioorg.Chem., 114, 2021
7DPR	E. coli GyrB ATPase domain in complex with methyl 3,4-dihydroxybenzoate 分子名称: 1H-benzimidazol-2-amine, DNA gyrase subunit B, PHOSPHATE ION, ... 著者 Yu, Y, Zhou, H. 登録日 2020-12-21 公開日 2021-10-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Identification of new building blocks by fragment screening for discovering GyrB inhibitors. Bioorg.Chem., 114, 2021
7DPS	E. coli GyrB ATPase domain in complex with Methyl 4-hydroxycinnamate 分子名称: 1H-benzimidazol-2-amine, DNA gyrase subunit B, PHOSPHATE ION, ... 著者 Yu, Y, Zhou, H. 登録日 2020-12-21 公開日 2021-10-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Identification of new building blocks by fragment screening for discovering GyrB inhibitors. Bioorg.Chem., 114, 2021
7DQH	E. coli GyrB ATPase domain in complex with 2-hydroxybenzamide 分子名称: 1H-benzimidazol-2-amine, DNA gyrase subunit B, PHOSPHATE ION, ... 著者 Yu, Y, Zhou, H. 登録日 2020-12-23 公開日 2021-10-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Identification of new building blocks by fragment screening for discovering GyrB inhibitors. Bioorg.Chem., 114, 2021
7DQI	E. coli GyrB ATPase domain in complex with Esculetin 分子名称: 1H-benzimidazol-2-amine, 6,7-bis(oxidanyl)chromen-2-one, DNA gyrase subunit B, ... 著者 Yu, Y, Zhou, H. 登録日 2020-12-23 公開日 2021-10-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Identification of new building blocks by fragment screening for discovering GyrB inhibitors. Bioorg.Chem., 114, 2021

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