PDB: 2579 件ウェブページステータス検索Chemie searchBIRD

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8FFW	Cryo-EM structure of the GR-Hsp90-FKBP51 complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... 著者 Noddings, C.M, Agard, D.A. 登録日 2022-12-10 公開日 2023-11-01 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
8FFV	Cryo-EM structure of the GR-Hsp90-FKBP52 complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... 著者 Noddings, C.M, Agard, D.A. 登録日 2022-12-10 公開日 2023-11-01 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
8GAE	Hsp90 provides platform for CRaf dephosphorylation by PP5 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... 著者 Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. 登録日 2023-02-22 公開日 2023-04-26 最終更新日 2023-05-03 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun, 14, 2023
8WR8	The Crystal Structure of cGAS from Biortus 分子名称: Cyclic GMP-AMP synthase 著者 Wang, F, Cheng, W, Yuan, Z, Lin, D, Guo, S. 登録日 2023-10-13 公開日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 The Crystal Structure of cGAS from Biortus To Be Published
1DAK	DETHIOBIOTIN SYNTHETASE FROM ESCHERICHIA COLI, COMPLEX REACTION INTERMEDIATE ADP AND MIXED ANHYDRIDE 分子名称: ADENOSINE-5'-DIPHOSPHATE, DETHIOBIOTIN SYNTHETASE, MAGNESIUM ION, ... 著者 Kaeck, H, Gibson, K.J, Lindqvist, Y, Schneider, G. 登録日 1998-03-31 公開日 1999-04-06 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Snapshot of a phosphorylated substrate intermediate by kinetic crystallography. Proc.Natl.Acad.Sci.USA, 95, 1998
4U03	Structure of the vibrio cholerae di-nucleotide cyclase (DncV) in complex with GTP and 5MTHFGLU2 分子名称: Cyclic AMP-GMP synthase, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Zhu, D.Y, Xiang, Y. 登録日 2014-07-11 公開日 2014-09-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.041 Å) 主引用文献 Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates. Mol.Cell, 55, 2014
8J07	96nm repeat of human respiratory doublet microtubule and associated axonemal complexes 分子名称: ACTA2, Axonemal dynein light intermediate polypeptide 1, Calaxin, ... 著者 Gui, M, Brown, A. 登録日 2023-04-09 公開日 2023-07-26 最終更新日 2023-08-02 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Axonemal structures reveal mechanoregulatory and disease mechanisms. Nature, 618, 2023
1NBE	ASPARTATE TRANSCARBAMOYLASE REGULATORY CHAIN MUTANT (T82A) 分子名称: ASPARTATE TRANSCARBAMOYLASE, D-MALATE, ZINC ION 著者 Williams, M.K, Stec, B, Kantrowitz, E.R. 登録日 1998-04-25 公開日 1998-10-14 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A single mutation in the regulatory chain of Escherichia coli aspartate transcarbamoylase results in an extreme T-state structure. J.Mol.Biol., 281, 1998
5AIR	Structural analysis of mouse GSK3beta fused with LRP6 peptide. 分子名称: Low-density lipoprotein receptor-related protein 6,Glycogen synthase kinase-3 beta, MALONATE ION 著者 Kim, K.L. 登録日 2015-02-17 公開日 2015-04-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Structural Analysis of Mouse Gsk3 Beta Fused with Lrp6 Peptide Biodesign, 3, 2015
2OI4	Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... 著者 Maksimoska, J, Meggers, E. 登録日 2007-01-10 公開日 2007-04-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand. Org.Biomol.Chem., 5, 2007
6G2H	Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) core at 4.6 A resolution 分子名称: Acetyl-CoA carboxylase 1 著者 Hunkeler, M, Hagmann, A, Stuttfeld, E, Chami, M, Stahlberg, H, Maier, T. 登録日 2018-03-23 公開日 2018-06-13 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Structural basis for regulation of human acetyl-CoA carboxylase. Nature, 558, 2018
6G2D	Citrate-induced acetyl-CoA carboxylase (ACC-Cit) filament at 5.4 A resolution 分子名称: Acetyl-CoA carboxylase 1 著者 Hunkeler, M, Hagmann, A, Stuttfeld, E, Chami, M, Stahlberg, H, Maier, T. 登録日 2018-03-23 公開日 2018-06-13 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (5.4 Å) 主引用文献 Structural basis for regulation of human acetyl-CoA carboxylase. Nature, 558, 2018
6HK3	Crystal structure of GSK-3B in complex with pyrazine inhibitor C44 分子名称: 3-azanyl-~{N}-(2-methoxyphenyl)-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazine-2-carboxamide, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Piretti, V, Giabbai, B, Demitri, N, Di Martino, R, Tripathi, S.K, Gobbo, D, Decherchi, S, Storici, P, Girotto, S, Cavalli, A. 登録日 2018-09-05 公開日 2019-07-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Investigating Drug-Target Residence Time in Kinases through Enhanced Sampling Simulations. J Chem Theory Comput, 15, 2019
6HK7	Crystal structure of GSK-3B in complex with pyrazine inhibitor C50 分子名称: 3-azanyl-~{N}-(2-methoxyethyl)-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazine-2-carboxamide, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Piretti, V, Giabbai, B, Demitri, N, Di Martino, R, Tripathi, S.K, Gobbo, D, Decherchi, S, Storici, P, Girotto, S, Cavalli, A. 登録日 2018-09-05 公開日 2019-07-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Investigating Drug-Target Residence Time in Kinases through Enhanced Sampling Simulations. J Chem Theory Comput, 15, 2019
2C00	Crystal Structure of Biotin Carboxylase from Pseudomonas aeruginosa in apo form 分子名称: BIOTIN CARBOXYLASE, SULFATE ION 著者 Mochalkin, I. 登録日 2008-03-21 公開日 2008-09-09 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Evidence for Substrate-Induced Synergism and Half-Sites Reactivity in Biotin Carboxylase. Protein Sci., 17, 2008
8P1T	Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor Z237451470 分子名称: 1,2-ETHANEDIOL, 6-cyclopropyl-~{N}-(1~{H}-indazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-b]pyridine-4-carboxamide, CHLORIDE ION, ... 著者 Thomsen, M, Thieulin-Pardo, G, Neumann, L. 登録日 2023-05-12 公開日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.442 Å) 主引用文献 Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg.Med.Chem.Lett., 94, 2023
8P1V	Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric compound 2 分子名称: 1,2-ETHANEDIOL, 6-cyclopropyl-~{N}-(2-methylindazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-b]pyridine-4-carboxamide, CHLORIDE ION, ... 著者 Thomsen, M, Thieulin-Pardo, G, Neumann, L. 登録日 2023-05-12 公開日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg.Med.Chem.Lett., 94, 2023
8P1W	Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with allosteric compound STL232591 分子名称: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, 8-methoxy-1-(4-methoxyphenyl)-3-methyl-2-oxidanyl-[1]benzofuro[3,2-c]pyridine, ... 著者 Thomsen, M, Thieulin-Pardo, G, Neumann, L. 登録日 2023-05-12 公開日 2023-08-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg.Med.Chem.Lett., 94, 2023
6G2I	Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) at 5.9 A resolution 分子名称: Acetyl-CoA carboxylase 1, Breast cancer type 1 susceptibility protein 著者 Hunkeler, M, Hagmann, A, Stuttfeld, E, Chami, M, Stahlberg, H, Maier, T. 登録日 2018-03-23 公開日 2018-06-13 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (5.9 Å) 主引用文献 Structural basis for regulation of human acetyl-CoA carboxylase. Nature, 558, 2018
2VPQ	Crystal structure of biotin carboxylase from S. aureus complexed with AMPPNP 分子名称: ACETYL-COA CARBOXYLASE, CHLORIDE ION, MAGNESIUM ION, ... 著者 Mochalkin, I. 登録日 2008-03-03 公開日 2008-09-09 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Evidence for Substrate-Induced Synergism and Half-Sites Reactivity in Biotin Carboxylase. Protein Sci., 17, 2008
2R7N	Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ADP and FAICAR 分子名称: 5-(formylamino)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide, 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Zhang, Y, White, R.H, Ealick, S.E. 登録日 2007-09-09 公開日 2007-12-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
6NT9	Cryo-EM structure of the complex between human TBK1 and chicken STING 分子名称: Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein 著者 Shang, G, Zhang, C, Chen, Z.J, Bai, X, Zhang, X. 登録日 2019-01-28 公開日 2019-03-06 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis of STING binding with and phosphorylation by TBK1. Nature, 567, 2019
7RRO	Structure of the 48-nm repeat doublet microtubule from bovine tracheal cilia 分子名称: Armadillo repeat containing 4, Chromosome 3 C1orf194 homolog, Cilia and flagella associated protein 161, ... 著者 Gui, M, Anderson, J.R, Botsch, J.J, Meleppattu, S, Singh, S.K, Zhang, Q, Brown, A. 登録日 2021-08-10 公開日 2021-10-27 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 De novo identification of mammalian ciliary motility proteins using cryo-EM. Cell, 184, 2021
6NOY	Structure of Cyanothece McdB 分子名称: Maintenance of carboxysome positioning B protein, Mcsb 著者 Schumacher, M.A. 登録日 2019-01-16 公開日 2019-04-24 最終更新日 2019-06-26 実験手法 X-RAY DIFFRACTION (3.46 Å) 主引用文献 Structures of maintenance of carboxysome distribution Walker-box McdA and McdB adaptor homologs. Nucleic Acids Res., 47, 2019
1JDB	CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIA COLI 分子名称: ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE, CHLORIDE ION, ... 著者 Thoden, J.B, Holden, H.M, Wesenberg, G, Raushel, F.M, Rayment, I. 登録日 1997-03-25 公開日 1998-06-17 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution. Acta Crystallogr.,Sect.D, 55, 1999

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