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8P1V

Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric compound 2

This is a non-PDB format compatible entry.
Summary for 8P1V
Entry DOI10.2210/pdb8p1v/pdb
DescriptorS-adenosylmethionine synthase isoform type-2, S-ADENOSYLMETHIONINE, 6-cyclopropyl-~{N}-(2-methylindazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-b]pyridine-4-carboxamide, ... (6 entities in total)
Functional Keywordsmethionine adenosyltransferase, s-adenosylmethionine synthase isoform 2 type-2, sam, allosteric inhibitor, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight46866.64
Authors
Thomsen, M.,Thieulin-Pardo, G.,Neumann, L. (deposition date: 2023-05-12, release date: 2023-08-30)
Primary citationKalliokoski, T.,Kettunen, H.,Kumpulainen, E.,Kettunen, E.,Thieulin-Pardo, G.,Neumann, L.,Thomsen, M.,Paul, R.,Malyutina, A.,Georgiadou, M.
Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening.
Bioorg.Med.Chem.Lett., 94:129450-129450, 2023
Cited by
PubMed: 37591318
DOI: 10.1016/j.bmcl.2023.129450
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.54 Å)
Structure validation

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