1HMF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1hmf by Molmil](/molmil-images/mine/1hmf) | STRUCTURE OF THE HMG BOX MOTIF IN THE B-DOMAIN OF HMG1 | 分子名称: | HIGH MOBILITY GROUP PROTEIN FRAGMENT-B | 著者 | Weir, H.M, Kraulis, P.J, Hill, C.S, Raine, A.R.C, Laue, E.D, Thomas, J.O. | 登録日 | 1994-03-07 | 公開日 | 1994-05-31 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the HMG box motif in the B-domain of HMG1. EMBO J., 12, 1993
|
|
6KJZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6kjz by Molmil](/molmil-images/mine/6kjz) | Crystal structure of PDE4D catalytic domain complexed with compound 1 | 分子名称: | 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2019-07-23 | 公開日 | 2020-03-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.200001 Å) | 主引用文献 | Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J.Med.Chem., 63, 2020
|
|
7VGG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vgg by Molmil](/molmil-images/mine/7vgg) | Cryo-EM structure of Ultraviolet-B activated UVR8 in complex with COP1 | 分子名称: | E3 ubiquitin-protein ligase COP1, Ultraviolet-B receptor UVR8 | 著者 | Wang, Y.D, Wang, L.X, Guan, Z.Y, Yin, P. | 登録日 | 2021-09-16 | 公開日 | 2022-05-04 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insight into UV-B-activated UVR8 bound to COP1. Sci Adv, 8, 2022
|
|
6ME2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6me2 by Molmil](/molmil-images/mine/6me2) | XFEL crystal structure of human melatonin receptor MT1 in complex with ramelteon | 分子名称: | DI(HYDROXYETHYL)ETHER, N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide, OLEIC ACID, ... | 著者 | Stauch, B, Johansson, L.C, McCorvy, J.D, Patel, N, Han, G.W, Gati, C, Batyuk, A, Ishchenko, A, Brehm, W, White, T.A, Michaelian, N, Madsen, C, Zhu, L, Grant, T.D, Grandner, J.M, Olsen, R.H.J, Tribo, A.R, Weierstall, U, Roth, B.L, Katritch, V, Liu, W, Cherezov, V. | 登録日 | 2018-09-05 | 公開日 | 2019-04-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of ligand recognition at the human MT1melatonin receptor. Nature, 569, 2019
|
|
7EAL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7eal by Molmil](/molmil-images/mine/7eal) | |
7EB9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7eb9 by Molmil](/molmil-images/mine/7eb9) | |
2VWE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vwe by Molmil](/molmil-images/mine/2vwe) | Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralizing Antibody Fab Fragment | 分子名称: | ANTI-VEGF-B MONOCLONAL ANTIBODY, VASCULAR ENDOTHELIAL GROWTH FACTOR B | 著者 | Leonard, P, Scotney, P.D, Jabeen, T, Iyer, S, Fabri, L.J, Nash, A.D, Acharya, K.R. | 登録日 | 2008-06-23 | 公開日 | 2008-11-04 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralising Antibody Fab Fragment. J.Mol.Biol., 384, 2008
|
|
5DOO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5doo by Molmil](/molmil-images/mine/5doo) | The structure of PKMT2 from Rickettsia typhi | 分子名称: | CALCIUM ION, protein lysine methyltransferase 2 | 著者 | Noinaj, N, Abeykoon, A, He, Y, Yang, D.C, Buchanan, S.K. | 登録日 | 2015-09-11 | 公開日 | 2016-08-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.133 Å) | 主引用文献 | Structural Insights into Substrate Recognition and Catalysis in Outer Membrane Protein B (OmpB) by Protein-lysine Methyltransferases from Rickettsia. J.Biol.Chem., 291, 2016
|
|
3PBH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3pbh by Molmil](/molmil-images/mine/3pbh) | |
5HS9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hs9 by Molmil](/molmil-images/mine/5hs9) | |
5UKQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ukq by Molmil](/molmil-images/mine/5ukq) | |
6CVK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6cvk by Molmil](/molmil-images/mine/6cvk) | |
6CWD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6cwd by Molmil](/molmil-images/mine/6cwd) | |
1THE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1the by Molmil](/molmil-images/mine/1the) | |
3PGW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3pgw by Molmil](/molmil-images/mine/3pgw) | Crystal structure of human U1 snRNP | 分子名称: | DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3', Sm B, Sm G, ... | 著者 | Weber, G, Trowitzsch, S, Kastner, B, Luehrmann, R, Wahl, M.C. | 登録日 | 2010-11-02 | 公開日 | 2010-12-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Functional organization of the Sm core in the crystal structure of human U1 snRNP. Embo J., 29, 2010
|
|
5C6T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5c6t by Molmil](/molmil-images/mine/5c6t) | Crystal structure of HCMV glycoprotein B in complex with 1G2 Fab | 分子名称: | 1G2 Fab heavy chain, 1G2 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Chandramouli, S, Ciferri, C, Settembre, E.C, Carfi, A. | 登録日 | 2015-06-23 | 公開日 | 2015-09-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody. Nat Commun, 6, 2015
|
|
5T6Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5t6z by Molmil](/molmil-images/mine/5t6z) | KIR3DL1 in complex with HLA-B*57:01-TW10 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Decapeptide: THR-SER-THR-LEU-GLN-GLU-GLN-ILE-GLY-TRP, ... | 著者 | Pymm, P, Rossjohn, J, Vivian, J.P. | 登録日 | 2016-09-02 | 公開日 | 2017-03-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape. Nat. Struct. Mol. Biol., 24, 2017
|
|
6KH9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6kh9 by Molmil](/molmil-images/mine/6kh9) | Solution structure of bovine insulin amyloid intermediate-1 | 分子名称: | Insulin A chain, Insulin B chain | 著者 | Ratha, B.N, Kar, R.K, Brender, J.B, Bhunia, A. | 登録日 | 2019-07-14 | 公開日 | 2020-08-12 | 最終更新日 | 2020-11-18 | 実験手法 | SOLUTION NMR | 主引用文献 | High-resolution structure of a partially folded insulin aggregation intermediate. Proteins, 88, 2020
|
|
6KK0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6kk0 by Molmil](/molmil-images/mine/6kk0) | Crystal structure of PDE4D catalytic domain complexed with compound 4e | 分子名称: | 7-[8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-5-oxidanyl-6-oxidanylidene-pyrano[3,2-b]xanthen-9-yl]oxyheptanoic acid, MAGNESIUM ION, ZINC ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2019-07-23 | 公開日 | 2020-03-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.20008755 Å) | 主引用文献 | Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J.Med.Chem., 63, 2020
|
|
5T31
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5t31 by Molmil](/molmil-images/mine/5t31) | Exploiting an Asp-Glu switch in Glycogen Synthase Kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia | 分子名称: | (4~{S})-4-ethyl-7,7-dimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta | 著者 | Stein, A.J, Holson, E.B, Wagner, F.F, Cambell, A.J. | 登録日 | 2016-08-24 | 公開日 | 2018-02-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med, 10, 2018
|
|
6KH8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6kh8 by Molmil](/molmil-images/mine/6kh8) | Solution structure of Zn free Bovine Pancreatic Insulin in 20% acetic acid-d4 (pH 1.9) | 分子名称: | Insulin A Chain, Insulin B chain | 著者 | Bhunia, A, Ratha, B.N, Kar, R.K, Brender, J.R. | 登録日 | 2019-07-14 | 公開日 | 2020-10-07 | 最終更新日 | 2020-11-18 | 実験手法 | SOLUTION NMR | 主引用文献 | High-resolution structure of a partially folded insulin aggregation intermediate. Proteins, 88, 2020
|
|
4CFF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cff by Molmil](/molmil-images/mine/4cff) | Structure of full length human AMPK in complex with a small molecule activator, a thienopyridone derivative (A-769662) | 分子名称: | 3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1, ... | 著者 | Xiao, B, Sanders, M.J, Carmena, D, Bright, N.J, Haire, L.F, Underwood, E, Patel, B.R, Heath, R.B, Walker, P.A, Hallen, S, Giordanetto, F, Martin, S.R, Carling, D, Gamblin, S.J. | 登録日 | 2013-11-14 | 公開日 | 2013-12-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.924 Å) | 主引用文献 | Structural Basis of Ampk Regulation by Small Molecule Activators. Nat.Commun., 4, 2013
|
|
5DPD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5dpd by Molmil](/molmil-images/mine/5dpd) | The structure of PKMT1 from Rickettsia prowazekii in complex with AdoMet | 分子名称: | S-ADENOSYLMETHIONINE, protein lysine methyltransferase 1 | 著者 | Noinaj, N, Abeykoon, A, He, Y, Yang, D.C, Buchanan, S.K. | 登録日 | 2015-09-12 | 公開日 | 2016-08-10 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Insights into Substrate Recognition and Catalysis in Outer Membrane Protein B (OmpB) by Protein-lysine Methyltransferases from Rickettsia. J.Biol.Chem., 291, 2016
|
|
4O13
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4o13 by Molmil](/molmil-images/mine/4o13) | The crystal structure of NAMPT in complex with GNE-618 | 分子名称: | 1,2-ETHANEDIOL, N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxamide, Nicotinamide phosphoribosyltransferase, ... | 著者 | Oh, A, Coons, M, Brillantes, B, Wang, W. | 登録日 | 2013-12-15 | 公開日 | 2014-10-22 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
|
|
4B94
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4b94 by Molmil](/molmil-images/mine/4b94) | Crystal structure of human Mps1 TPR domain | 分子名称: | DI(HYDROXYETHYL)ETHER, DUAL SPECIFICITY PROTEIN KINASE TTK, GLYCEROL, ... | 著者 | Littler, D, von Castelmur, E, De Marco, V, Perrakis, A. | 登録日 | 2012-08-31 | 公開日 | 2013-04-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A Tpr Domain-Containing N-Terminal Module of Mps1 is Required for its Kinetochore Localization by Aurora B. J.Cell Biol., 201, 2013
|
|