PDB: 217477 件ウェブページステータス検索Chemie searchBIRD

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1HMF	STRUCTURE OF THE HMG BOX MOTIF IN THE B-DOMAIN OF HMG1 分子名称: HIGH MOBILITY GROUP PROTEIN FRAGMENT-B 著者 Weir, H.M, Kraulis, P.J, Hill, C.S, Raine, A.R.C, Laue, E.D, Thomas, J.O. 登録日 1994-03-07 公開日 1994-05-31 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure of the HMG box motif in the B-domain of HMG1. EMBO J., 12, 1993
6KJZ	Crystal structure of PDE4D catalytic domain complexed with compound 1 分子名称: 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one, MAGNESIUM ION, ZINC ION, ... 著者 Huang, Y.-Y, He, X, Luo, H.-B. 登録日 2019-07-23 公開日 2020-03-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.200001 Å) 主引用文献 Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J.Med.Chem., 63, 2020
7VGG	Cryo-EM structure of Ultraviolet-B activated UVR8 in complex with COP1 分子名称: E3 ubiquitin-protein ligase COP1, Ultraviolet-B receptor UVR8 著者 Wang, Y.D, Wang, L.X, Guan, Z.Y, Yin, P. 登録日 2021-09-16 公開日 2022-05-04 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insight into UV-B-activated UVR8 bound to COP1. Sci Adv, 8, 2022
6ME2	XFEL crystal structure of human melatonin receptor MT1 in complex with ramelteon 分子名称: DI(HYDROXYETHYL)ETHER, N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide, OLEIC ACID, ... 著者 Stauch, B, Johansson, L.C, McCorvy, J.D, Patel, N, Han, G.W, Gati, C, Batyuk, A, Ishchenko, A, Brehm, W, White, T.A, Michaelian, N, Madsen, C, Zhu, L, Grant, T.D, Grandner, J.M, Olsen, R.H.J, Tribo, A.R, Weierstall, U, Roth, B.L, Katritch, V, Liu, W, Cherezov, V. 登録日 2018-09-05 公開日 2019-04-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis of ligand recognition at the human MT1melatonin receptor. Nature, 569, 2019
7EAL	The structure of the A20-Binding Inhibitor of NF-kB 1 in complex with di-ubiquitin 分子名称: GLYCEROL, TNFAIP3-interacting protein 1, ubiquitin 著者 Lo, Y.C, Lin, S.C. 登録日 2021-03-07 公開日 2021-07-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural and Biochemical Basis for Higher-Order Assembly between A20-Binding Inhibitor of NF-kappa B 1 (ABIN1) and M1-Linked Ubiquitins. J.Mol.Biol., 433, 2021
7EB9	The structure of the A20-binding inhibitor of NF-kB 1 in complex with tetra-ubiquitin 分子名称: TNFAIP3-interacting protein 1, tetra ubiquitin 著者 Lo, Y.C, Lin, S.C. 登録日 2021-03-09 公開日 2021-07-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural and Biochemical Basis for Higher-Order Assembly between A20-Binding Inhibitor of NF-kappa B 1 (ABIN1) and M1-Linked Ubiquitins. J.Mol.Biol., 433, 2021
2VWE	Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralizing Antibody Fab Fragment 分子名称: ANTI-VEGF-B MONOCLONAL ANTIBODY, VASCULAR ENDOTHELIAL GROWTH FACTOR B 著者 Leonard, P, Scotney, P.D, Jabeen, T, Iyer, S, Fabri, L.J, Nash, A.D, Acharya, K.R. 登録日 2008-06-23 公開日 2008-11-04 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralising Antibody Fab Fragment. J.Mol.Biol., 384, 2008
5DOO	The structure of PKMT2 from Rickettsia typhi 分子名称: CALCIUM ION, protein lysine methyltransferase 2 著者 Noinaj, N, Abeykoon, A, He, Y, Yang, D.C, Buchanan, S.K. 登録日 2015-09-11 公開日 2016-08-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.133 Å) 主引用文献 Structural Insights into Substrate Recognition and Catalysis in Outer Membrane Protein B (OmpB) by Protein-lysine Methyltransferases from Rickettsia. J.Biol.Chem., 291, 2016
3PBH	REFINED CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 2.5 ANGSTROM RESOLUTION 分子名称: PROCATHEPSIN B 著者 Podobnik, M, Turk, D, Kuhelj, R, Turk, V. 登録日 1997-02-13 公開日 1998-02-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the wild-type human procathepsin B at 2.5 A resolution reveals the native active site of a papain-like cysteine protease zymogen. J.Mol.Biol., 271, 1997
5HS9	Crystal structure of the quinone-bound YodB from B. subtilis 分子名称: HTH-type transcriptional regulator YodB 著者 Lee, S.J, Lee, I.G, Lee, B.J. 登録日 2016-01-25 公開日 2016-08-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Two distinct mechanisms of transcriptional regulation by the redox sensor YodB Proc.Natl.Acad.Sci.USA, 113, 2016
5UKQ	Structure of unliganded anti-gp120 CD4bs antibody DH522.2 Fab 分子名称: DH522.2 Fab fragment heavy chain, DH522.2 Fab fragment light chain, GLYCEROL 著者 Nicely, N.I. 登録日 2017-01-23 公開日 2017-12-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations. Nat Commun, 8, 2017
6CVK	Hepatitis B e-antigen in complex with scFv e13 分子名称: Capsid protein, Single chain variable fragment (scFv) e13 著者 Eren, E, Steven, A.C, Wingfield, P.T. 登録日 2018-03-28 公開日 2018-08-29 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Structures of Hepatitis B Virus Core- and e-Antigen Immune Complexes Suggest Multi-point Inhibition. Structure, 26, 2018
6CWD	Hepatitis B core-antigen in complex with scFv e13 分子名称: Capsid protein, Single chain variable fragment (scFv) e13 著者 Eren, E, Steven, A.C, Wingfield, P.T. 登録日 2018-03-30 公開日 2018-08-29 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.33 Å) 主引用文献 Structures of Hepatitis B Virus Core- and e-Antigen Immune Complexes Suggest Multi-point Inhibition. Structure, 26, 2018
1THE	CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN 分子名称: Cathepsin B, amino{[(4S)-4-{[(benzyloxy)carbonyl]amino}-5-{[(2S)-1-(benzyloxy)-4-chloro-3-oxobutan-2-yl]amino}-5-oxopentyl]amino}met haniminium 著者 Huber, C.P, Jia, Z. 登録日 1995-09-15 公開日 1996-03-10 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. J.Biol.Chem., 270, 1995
3PGW	Crystal structure of human U1 snRNP 分子名称: DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3', Sm B, Sm G, ... 著者 Weber, G, Trowitzsch, S, Kastner, B, Luehrmann, R, Wahl, M.C. 登録日 2010-11-02 公開日 2010-12-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (4.4 Å) 主引用文献 Functional organization of the Sm core in the crystal structure of human U1 snRNP. Embo J., 29, 2010
5C6T	Crystal structure of HCMV glycoprotein B in complex with 1G2 Fab 分子名称: 1G2 Fab heavy chain, 1G2 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Chandramouli, S, Ciferri, C, Settembre, E.C, Carfi, A. 登録日 2015-06-23 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody. Nat Commun, 6, 2015
5T6Z	KIR3DL1 in complex with HLA-B*57:01-TW10 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Decapeptide: THR-SER-THR-LEU-GLN-GLU-GLN-ILE-GLY-TRP, ... 著者 Pymm, P, Rossjohn, J, Vivian, J.P. 登録日 2016-09-02 公開日 2017-03-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape. Nat. Struct. Mol. Biol., 24, 2017
6KH9	Solution structure of bovine insulin amyloid intermediate-1 分子名称: Insulin A chain, Insulin B chain 著者 Ratha, B.N, Kar, R.K, Brender, J.B, Bhunia, A. 登録日 2019-07-14 公開日 2020-08-12 最終更新日 2020-11-18 実験手法 SOLUTION NMR 主引用文献 High-resolution structure of a partially folded insulin aggregation intermediate. Proteins, 88, 2020
6KK0	Crystal structure of PDE4D catalytic domain complexed with compound 4e 分子名称: 7-[8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-5-oxidanyl-6-oxidanylidene-pyrano[3,2-b]xanthen-9-yl]oxyheptanoic acid, MAGNESIUM ION, ZINC ION, ... 著者 Huang, Y.-Y, He, X, Luo, H.-B. 登録日 2019-07-23 公開日 2020-03-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.20008755 Å) 主引用文献 Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J.Med.Chem., 63, 2020
5T31	Exploiting an Asp-Glu switch in Glycogen Synthase Kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia 分子名称: (4~{S})-4-ethyl-7,7-dimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta 著者 Stein, A.J, Holson, E.B, Wagner, F.F, Cambell, A.J. 登録日 2016-08-24 公開日 2018-02-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med, 10, 2018
6KH8	Solution structure of Zn free Bovine Pancreatic Insulin in 20% acetic acid-d4 (pH 1.9) 分子名称: Insulin A Chain, Insulin B chain 著者 Bhunia, A, Ratha, B.N, Kar, R.K, Brender, J.R. 登録日 2019-07-14 公開日 2020-10-07 最終更新日 2020-11-18 実験手法 SOLUTION NMR 主引用文献 High-resolution structure of a partially folded insulin aggregation intermediate. Proteins, 88, 2020
4CFF	Structure of full length human AMPK in complex with a small molecule activator, a thienopyridone derivative (A-769662) 分子名称: 3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1, ... 著者 Xiao, B, Sanders, M.J, Carmena, D, Bright, N.J, Haire, L.F, Underwood, E, Patel, B.R, Heath, R.B, Walker, P.A, Hallen, S, Giordanetto, F, Martin, S.R, Carling, D, Gamblin, S.J. 登録日 2013-11-14 公開日 2013-12-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.924 Å) 主引用文献 Structural Basis of Ampk Regulation by Small Molecule Activators. Nat.Commun., 4, 2013
5DPD	The structure of PKMT1 from Rickettsia prowazekii in complex with AdoMet 分子名称: S-ADENOSYLMETHIONINE, protein lysine methyltransferase 1 著者 Noinaj, N, Abeykoon, A, He, Y, Yang, D.C, Buchanan, S.K. 登録日 2015-09-12 公開日 2016-08-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural Insights into Substrate Recognition and Catalysis in Outer Membrane Protein B (OmpB) by Protein-lysine Methyltransferases from Rickettsia. J.Biol.Chem., 291, 2016
4O13	The crystal structure of NAMPT in complex with GNE-618 分子名称: 1,2-ETHANEDIOL, N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxamide, Nicotinamide phosphoribosyltransferase, ... 著者 Oh, A, Coons, M, Brillantes, B, Wang, W. 登録日 2013-12-15 公開日 2014-10-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
4B94	Crystal structure of human Mps1 TPR domain 分子名称: DI(HYDROXYETHYL)ETHER, DUAL SPECIFICITY PROTEIN KINASE TTK, GLYCEROL, ... 著者 Littler, D, von Castelmur, E, De Marco, V, Perrakis, A. 登録日 2012-08-31 公開日 2013-04-24 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A Tpr Domain-Containing N-Terminal Module of Mps1 is Required for its Kinetochore Localization by Aurora B. J.Cell Biol., 201, 2013

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