6ME2

XFEL crystal structure of human melatonin receptor MT1 in complex with ramelteon

Summary for 6ME2

Entry DOI	10.2210/pdb6me2/pdb
Descriptor	chimera protein of Melatonin receptor type 1A and GlgA glycogen synthase, N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide, OLEIC ACID, ... (5 entities in total)
Functional Keywords	gpcr, melatonin receptor type 1a (mt1), membrane protein, ramelteon, xfel, lcp, pgs, circadian rhythm, jetlag
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	57584.79
Authors	Stauch, B.,Johansson, L.C.,McCorvy, J.D.,Patel, N.,Han, G.W.,Gati, C.,Batyuk, A.,Ishchenko, A.,Brehm, W.,White, T.A.,Michaelian, N.,Madsen, C.,Zhu, L.,Grant, T.D.,Grandner, J.M.,Olsen, R.H.J.,Tribo, A.R.,Weierstall, U.,Roth, B.L.,Katritch, V.,Liu, W.,Cherezov, V. (deposition date: 2018-09-05, release date: 2019-04-24, Last modification date: 2023-10-11)
Primary citation	Stauch, B.,Johansson, L.C.,McCorvy, J.D.,Patel, N.,Han, G.W.,Huang, X.P.,Gati, C.,Batyuk, A.,Slocum, S.T.,Ishchenko, A.,Brehm, W.,White, T.A.,Michaelian, N.,Madsen, C.,Zhu, L.,Grant, T.D.,Grandner, J.M.,Shiriaeva, A.,Olsen, R.H.J.,Tribo, A.R.,Yous, S.,Stevens, R.C.,Weierstall, U.,Katritch, V.,Roth, B.L.,Liu, W.,Cherezov, V. Structural basis of ligand recognition at the human MT1melatonin receptor. Nature, 569:284-288, 2019 Cited by PubMed: 31019306 DOI: 10.1038/s41586-019-1141-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation