PDB: 97310 件ウェブページステータス検索Chemie searchBIRD

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6XQY	Crystal structure of the catalytic domain of PBP2 S310A from Neisseria gonorrhoeae at pH 9.5 分子名称: CHLORIDE ION, Probable peptidoglycan D,D-transpeptidase PenA 著者 Fenton, B.A, Zhou, P, Davies, C. 登録日 2020-07-10 公開日 2021-07-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the beta 3-beta 4 loop to favor a low-affinity drug-binding state. J.Biol.Chem., 297, 2021
6XQX	Crystal structure of the catalytic domain of PBP2 S310A from Neisseria gonorrhoeae with the H514A mutation at pH 7.5 分子名称: 1,2-ETHANEDIOL, Probable peptidoglycan D,D-transpeptidase PenA, SULFATE ION 著者 Fenton, B.A, Zhou, P, Davies, C. 登録日 2020-07-10 公開日 2021-07-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the beta 3-beta 4 loop to favor a low-affinity drug-binding state. J.Biol.Chem., 297, 2021
6XTF	Crystal structure a Thioredoxin Reductase from Gloeobacter violaceus bound to its electron donor 分子名称: ACETATE ION, DI(HYDROXYETHYL)ETHER, FE2/S2 (INORGANIC) CLUSTER, ... 著者 Buey, R.M, Gonzalez-Holgado, G, Fernandez-Justel, D, Balsera, M. 登録日 2020-01-16 公開日 2021-07-28 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Unexpected diversity of ferredoxin-dependent thioredoxin reductases in cyanobacteria. Plant Physiol., 186, 2021
2SIC	REFINED CRYSTAL STRUCTURE OF THE COMPLEX OF SUBTILISIN BPN' AND STREPTOMYCES SUBTILISIN INHIBITOR AT 1.8 ANGSTROMS RESOLUTION 分子名称: CALCIUM ION, STREPTOMYCES SUBTILISIN INHIBITOR (SSI), SUBTILISIN BPN' 著者 Mitsui, Y, Takeuchi, Y, Hirono, S, Akagawa, H, Nakamura, K.T. 登録日 1991-04-01 公開日 1993-04-15 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Refined crystal structure of the complex of subtilisin BPN' and Streptomyces subtilisin inhibitor at 1.8 A resolution. J.Mol.Biol., 221, 1991
2IQ0	Crystal Structure of Aldose Reductase complexed with Hexanoic Acid 分子名称: Aldose reductase, HEXANOIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Harrison, D.H.T, Brownlee, J.M. 登録日 2006-10-12 公開日 2006-11-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes. Bioorg.Chem., 34, 2006
5F0Z	Crystal structure of Fructokinase from Vibrio cholerae O395 in fructose, ADP and calcium ion bound form 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Fructokinase, ... 著者 Paul, R, Nath, S, Sen, U. 登録日 2015-11-28 公開日 2016-11-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal structure of Fructokinase from Vibrio cholerae O395 in apo form To Be Published
2TCL	STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR 分子名称: CALCIUM ION, FIBROBLAST COLLAGENASE, SAMARIUM (III) ION, ... 著者 Winkler, F.K, Borkakoti, N, D'Arcy, A. 登録日 1994-09-07 公開日 1996-03-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor. Nat.Struct.Biol., 1, 1994
2J0Z	p53 tetramerization domain wild type 分子名称: CELLULAR TUMOR ANTIGEN P53 著者 Carbajo, R.J, Mora, P, Sanchez del Pino, M.M, Perez-Paya, E, Pineda-Lucena, A. 登録日 2006-08-08 公開日 2007-08-28 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solvent-exposed residues located in the beta-sheet modulate the stability of the tetramerization domain of p53--a structural and combinatorial approach. Proteins, 71, 2008
2DSW	Binding of chitin-like polysaccharides to protective signalling factor: crystal structure of the complex of signalling protein from sheep (SPS-40) with a pentasaccharide at 2.8 A resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase-3-like protein 1, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Srivastava, D.B, Ethayathulla, A.S, Kumar, J, Singh, N, Sharma, S, Kaur, P, Bhushan, A, Singh, T.P. 登録日 2006-07-07 公開日 2006-08-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Carbohydrate binding properties and carbohydrate induced conformational switch in sheep secretory glycoprotein (SPS-40): crystal structures of four complexes of SPS-40 with chitin-like oligosaccharides J.Struct.Biol., 158, 2007
1JMG	CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN-229 MUTANTS OF THYMIDYLATE SYNTHASE 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1997-09-13 公開日 1998-01-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase. J.Mol.Biol., 276, 1998
8IG4	Crystal structure of SARS-Cov-2 main protease in complex with GC376 分子名称: Non-structural protein 11, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide 著者 Zhou, X.L, Zhang, J, Li, J. 登録日 2023-02-20 公開日 2024-03-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376. J.Mol.Biol., 436, 2024
5EST	Crystallographic analysis of the inhibition of porcine pancreatic elastase by a peptidyl boronic acid: structure of a reaction intermediate 分子名称: CALCIUM ION, ELASTASE, N~2~-[(benzyloxy)carbonyl]-N-[(1R,2S)-1-(dihydroxyboranyl)-2-methylbutyl]-L-alaninamide, ... 著者 Takahashi, L.H, Radhakrishnan, R, Rosenfieldjunior, R.E, Meyerjunior, E.F. 登録日 1989-05-15 公開日 1992-04-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Crystallographic analysis of the inhibition of porcine pancreatic elastase by a peptidyl boronic acid: structure of a reaction intermediate. Biochemistry, 28, 1989
4HS2	Crystal Structure of the Human SPOP C-terminal Domain 分子名称: Speckle-type POZ protein 著者 Van Geersdaele, L.K, Stead, M.A, Carr, S.B, Wright, S.C. 登録日 2012-10-29 公開日 2013-09-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP. Acta Crystallogr.,Sect.D, 69, 2013
3SGA	STRUCTURES OF PRODUCT AND INHIBITOR COMPLEXES OF STREPTOMYCES GRISEUS PROTEASE A AT 1.8 ANGSTROMS RESOLUTION. A MODEL FOR SERINE PROTEASE CATALYSIS 分子名称: ACE-PRO-ALA-PRO-PHE-ALDEHYDE, PROTEINASE A (SGPA) 著者 Sielecki, A.R, James, M.N.G. 登録日 1990-05-29 公開日 1991-10-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structures of product and inhibitor complexes of Streptomyces griseus protease A at 1.8 A resolution. A model for serine protease catalysis. J.Mol.Biol., 144, 1980
8IG6	Crystal structure of MERS main protease in complex with GC376 分子名称: N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide, ORF1a 著者 Lin, C, Zhang, J, Li, J. 登録日 2023-02-20 公開日 2024-03-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376. J.Mol.Biol., 436, 2024
8IGA	Crystal structure of SARS-Cov-2 main protease K90R mutant in complex with GC376 分子名称: 3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide 著者 Wang, J, Zhang, J, Li, J. 登録日 2023-02-20 公開日 2024-03-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376. J.Mol.Biol., 436, 2024
8IOO	Crystal structure of Deinococcus radiodurans RecJ-like protein in complex with Mg2+ 分子名称: MAGNESIUM ION, RecJ-like protein, SULFATE ION 著者 Cheng, K. 登録日 2023-03-13 公開日 2024-03-20 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and functional investigation of the DHH/DHHA1 family proteins in Deinococcus radiodurans. Nucleic Acids Res., 52, 2024
8IG5	Crystal structure of SARS main protease in complex with GC376 分子名称: 3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide 著者 Lin, C, Zhang, J, Li, J. 登録日 2023-02-20 公開日 2024-03-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376. J.Mol.Biol., 436, 2024
5FN2	Cryo-EM structure of gamma secretase in complex with a drug DAPT 分子名称: Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... 著者 Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. 登録日 2015-11-10 公開日 2015-12-16 最終更新日 2019-09-04 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
6Y3X	Crystal structure of the Francisella novicida lysine decarboxylase LdcF 分子名称: Lysine decarboxylase 著者 Felix, J, Siebert, C, Gutsche, I, Renesto, P. 登録日 2020-02-19 公開日 2021-01-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structural and functional analysis of the Francisella lysine decarboxylase as a key actor in oxidative stress resistance. Sci Rep, 11, 2021
8IG7	Crystal structure of SARS-Cov-2 main protease G15S mutant in complex with GC376 分子名称: 3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide 著者 Zeng, P, Zhang, J, Li, J. 登録日 2023-02-20 公開日 2024-03-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376. J.Mol.Biol., 436, 2024
5FJL	Crystal structure of raptor adenovirus 1 fibre head, wild-type form 分子名称: CHLORIDE ION, FIBER PROTEIN 著者 Nguyen, T.H, van Raaij, M.J. 登録日 2015-10-09 公開日 2016-06-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Crystal Structure of Raptor Adenovirus 1 Fibre Head and Role of the Beta-Hairpin in Siadenovirus Fibre Head Domains Virol.J., 13, 2016
8IG9	Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with GC376 分子名称: 3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide 著者 Zou, X.F, Zhang, J, Li, J. 登録日 2023-02-20 公開日 2024-03-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376. J.Mol.Biol., 436, 2024
2UUY	Structure of a tick tryptase inhibitor in complex with bovine trypsin 分子名称: CALCIUM ION, CATIONIC TRYPSIN, CHLORIDE ION, ... 著者 Siebold, C, Paesen, G.C, Harlos, K, Peacey, M.F, Nuttall, P.A, Stuart, D.I. 登録日 2007-03-08 公開日 2007-04-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 A Tick Protein with a Modified Kunitz Fold Inhibits Human Tryptase. J.Mol.Biol., 368, 2007
8IG8	Crystal structure of SARS-Cov-2 main protease S46F mutant in complex with GC376 分子名称: 3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide 著者 Zeng, X.Y, Zhang, J, Li, J. 登録日 2023-02-20 公開日 2024-03-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376. J.Mol.Biol., 436, 2024

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