6XQX
Crystal structure of the catalytic domain of PBP2 S310A from Neisseria gonorrhoeae with the H514A mutation at pH 7.5
Summary for 6XQX
| Entry DOI | 10.2210/pdb6xqx/pdb |
| Descriptor | Probable peptidoglycan D,D-transpeptidase PenA, 1,2-ETHANEDIOL, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | pbp2, beta-lactam, antibiotic target, hydrolase |
| Biological source | Neisseria gonorrhoeae More |
| Total number of polymer chains | 2 |
| Total formula weight | 70840.84 |
| Authors | Fenton, B.A.,Zhou, P.,Davies, C. (deposition date: 2020-07-10, release date: 2021-07-21, Last modification date: 2023-10-18) |
| Primary citation | Fenton, B.A.,Tomberg, J.,Sciandra, C.A.,Nicholas, R.A.,Davies, C.,Zhou, P. Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the beta 3-beta 4 loop to favor a low-affinity drug-binding state. J.Biol.Chem., 297:101188-101188, 2021 Cited by PubMed: 34529975DOI: 10.1016/j.jbc.2021.101188 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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