PDB: 223790 件ウェブページステータス検索Chemie searchBIRD

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7C42	The crystal structure of Trypanosoma brucei RNase D 分子名称: CCHC-type domain-containing protein, ZINC ION 著者 Gao, Y.Q, Gan, J.H. 登録日 2020-05-14 公開日 2021-04-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei. Nucleic Acids Res., 49, 2021
8PVB	Structure of GABAAR determined by cryoEM at 100 keV 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ... 著者 McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. 登録日 2023-07-17 公開日 2023-11-29 最終更新日 2024-01-31 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure determination by cryoEM at 100 keV. Proc.Natl.Acad.Sci.USA, 120, 2023
6DEO	Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl 分子名称: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, Acetolactate synthase, CARBON DIOXIDE, ... 著者 Garcia, M.D, Guddat, L.W. 登録日 2018-05-12 公開日 2018-09-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.971 Å) 主引用文献 Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DEY	Aspartylglucosaminuria mutant structure and function 分子名称: Glycosylasparaginase, residues 188-331, residues 38-178 著者 Pande, S, Laksminarasimhan, D, Guo, H.C. 登録日 2018-05-13 公開日 2018-08-01 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Biochemical and structural insights into an allelic variant causing the lysosomal storage disorder - aspartylglucosaminuria. FEBS Lett., 592, 2018
6DVV	2.25 Angstrom Resolution Crystal Structure of 6-phospho-alpha-glucosidase from Klebsiella pneumoniae in Complex with NAD and Mn2+. 分子名称: 6-phospho-alpha-glucosidase, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Minasov, G, Shuvalova, L, Kiryukhina, O, Endres, M, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2018-06-25 公開日 2018-07-18 最終更新日 2023-06-14 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 A Structural Systems Biology Approach to High-Risk CG23 Klebsiella pneumoniae. Microbiol Resour Announc, 12, 2023
6DW7	SAMHD1 without Catalytic Nucleotides 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GLYCINE, ... 著者 Knecht, K.M, Buzovetsky, O, Schneider, C, Thomas, D, Srikanth, V, Kaderali, L, Tofoleanu, F, Reiss, K, Ferreiros, N, Geisslinger, G, Batista, V.S, Ji, X, Cinatl, J, Keppler, O.T, Xiong, Y. 登録日 2018-06-26 公開日 2018-10-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DWR	Trypsin serine protease modified with the protease inhibitor cyanobenzylsulfonylfluoride 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Cationic trypsin, ... 著者 Luo, M, Eaton, C.N, Phillips-Piro, C.M. 登録日 2018-06-27 公開日 2019-07-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.319 Å) 主引用文献 Paired Spectroscopic and Crystallographic Studies of Protease Active Sites Chemistryselect, 4, 2019
6DX1	Crystal structure of the viral OTU domain protease from Qalyub virus 分子名称: RNA-dependent RNA polymerase 著者 Dzimianski, J.V, Beldon, B.S, Daczkowski, C.M, Goodwin, O.Y, Pegan, S.D. 登録日 2018-06-28 公開日 2018-12-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.652 Å) 主引用文献 Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity. PLoS Pathog., 15, 2019
6DEQ	Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam 分子名称: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide, Acetolactate synthase, ... 著者 Garcia, M.D, Guddat, L.W. 登録日 2018-05-12 公開日 2018-09-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.127 Å) 主引用文献 Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7C46	Crystal Structure of Rv1045 toxin point variant K189A 分子名称: Rv1045 toxin, SULFATE ION 著者 Deep, A, Kaur, J, Thakur, K.G. 登録日 2020-05-15 公開日 2021-05-26 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Crystal Structure of Rv1045 toxin point variant K189A To Be Published
6YDG	X-ray structure of LPMO 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Auxiliary activity 9, CHLORIDE ION, ... 著者 Tandrup, T, Tryfona, T, Frandsen, K.E.H, Johansen, K.S, Dupree, P, Lo Leggio, L. 登録日 2020-03-20 公開日 2020-09-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Oligosaccharide Binding and Thermostability of Two Related AA9 Lytic Polysaccharide Monooxygenases. Biochemistry, 59, 2020
7CEN	an x-ray structure of ferric L29E Mb in complex with Mg(II) 分子名称: MAGNESIUM ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE 著者 Yuan, H, Lin, Y.W. 登録日 2020-06-23 公開日 2021-06-30 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 an x-ray structure of ferric L29E Mb in complex with Mg(II) To Be Published
7CEZ	An x-ray structure of G5K/Q8K/A19K/V21K Mb mutant with a positive charge 分子名称: Myoglobin, PROTOPORPHYRIN IX CONTAINING FE 著者 Yuan, H, Lin, Y.W. 登録日 2020-06-24 公開日 2021-06-30 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 An x-ray structure of G5K/Q8K/A19K/V21K Mb mutant with a positive charge To Be Published
7COE	Crystal structure of Receptor binding domain of MERS-CoV and KNIH90-F1 Fab complex 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain, ... 著者 Lee, J.Y, Song, J.Y, Lee, H.S, Hong, E, Jang, T.H. 登録日 2020-08-04 公開日 2021-08-04 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 The structure of a novel antibody against the spike protein inhibits Middle East respiratory syndrome coronavirus infections. Sci Rep, 12, 2022
8PO2	Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 33 bound to EGFRinsNPG [V948R] 分子名称: 1-cyclopropyl-~{N}-[3-[1-(1-propanoylazetidin-3-yl)-4-pyridin-4-yl-pyrazol-3-yl]phenyl]imidazole-4-carboxamide, Epidermal growth factor receptor 著者 Hargreaves, D. 登録日 2023-07-03 公開日 2024-06-05 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024
8PNZ	Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 16 bound to EGFR 分子名称: 1-[(3~{S})-3-[4-(6,7-dimethoxyquinazolin-4-yl)-3-(3-methoxyphenyl)pyrazol-1-yl]pyrrolidin-1-yl]propan-1-one, Epidermal growth factor receptor 著者 Hargreaves, D. 登録日 2023-07-03 公開日 2024-06-05 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024
7CTH	Cryo-EM structure of dengue virus serotype 2 in complex with the scFv fragment of the broadly neutralizing antibody EDE1 C10 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Core protein, Single Chain Variable Fragment 著者 Zhang, X, Sharma, A, Duquerroy, S, Zhou, Z.H, Rey, F.A. 登録日 2020-08-19 公開日 2021-12-01 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184, 2021
8PTV	IPNS variant N252Q in complex with Fe and ACV under anaerobic conditions 分子名称: FE (III) ION, Isopenicillin N synthase, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ... 著者 Rabe, P, Schofield, C.J. 登録日 2023-07-15 公開日 2024-07-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 IPNS variant N252Q in complex with Fe and ACV under anaerobic conditions To Be Published
8PY5	Isopenicillin N synthase in complex with Fe and ACdV under anaerobic conditions 分子名称: FE (III) ION, Isopenicillin N synthase, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ... 著者 Rabe, P, Schofield, C.J. 登録日 2023-07-25 公開日 2024-08-07 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Isopenicillin N synthase in complex with Fe and ACdV under anaerobic conditions To Be Published
8PY9	Isopenicillin N synthase in complex with Fe, O2, ACdV or thioaldehyde after 3s O2 exposure 分子名称: (2S)-2-azanyl-6-[[(2R)-1-[[(2R)-3-methyl-1-oxidanyl-1-oxidanylidene-butan-2-yl]amino]-1-oxidanylidene-3-sulfanylidene-propan-2-yl]amino]-6-oxidanylidene-hexanoic acid, FE (III) ION, Isopenicillin N synthase, ... 著者 Rabe, P, Schofield, C.J. 登録日 2023-07-25 公開日 2024-08-07 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Isopenicillin N synthase in complex with Fe, O2, ACdV or thioaldehyde after 3s O2 exposure To Be Published
8PY7	Isopenicillin N synthase in complex with Fe, ACdV and O2 after 1s O2 exposure 分子名称: FE (III) ION, Isopenicillin N synthase, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ... 著者 Rabe, P, Schofield, C.J. 登録日 2023-07-25 公開日 2024-08-07 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Isopenicillin N synthase in complex with Fe, ACdV and O2 after 1s O2 exposure To Be Published
8Q1D	D10N variant of beta-phosphoglucomutase from Lactococcus lactis in complex with fructose 1,6-bisphosphate 分子名称: 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, Beta-phosphoglucomutase, ... 著者 Cruz-Navarrete, F.A, Baxter, N.J, Flinders, A.J, Buzoianu, A, Cliff, M.J, Baker, P.J, Waltho, J.P. 登録日 2023-07-31 公開日 2024-08-07 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Peri active site catalysis of proline isomerisation is the molecular basis of allomorphy in beta-phosphoglucomutase. Commun Biol, 7, 2024
8PY6	Isopenicillin N synthase in complex with Fe and ACdV under anaerobic conditions 分子名称: FE (III) ION, Isopenicillin N synthase, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ... 著者 Rabe, P, Schofield, C.J. 登録日 2023-07-25 公開日 2024-08-07 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Isopenicillin N synthase in complex with Fe and ACdV under anaerobic conditions To Be Published
8PY8	Isopenicillin N synthase in complex with Fe, ACdV and O2 after 2s O2 exposure 分子名称: (2S)-2-azanyl-6-[[(2R)-1-[[(2R)-3-methyl-1-oxidanyl-1-oxidanylidene-butan-2-yl]amino]-1-oxidanylidene-3-sulfanylidene-propan-2-yl]amino]-6-oxidanylidene-hexanoic acid, FE (III) ION, Isopenicillin N synthase, ... 著者 Rabe, P, Schofield, C.J. 登録日 2023-07-25 公開日 2024-08-07 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Isopenicillin N synthase in complex with Fe, ACdV and O2 after 2s O2 exposure To Be Published
8PYA	Isopenicillin N synthase in complex with Fe, O2, ACdV or thioaldehyde after 4s O2 exposure 分子名称: (2S)-2-azanyl-6-[[(2R)-1-[[(2R)-3-methyl-1-oxidanyl-1-oxidanylidene-butan-2-yl]amino]-1-oxidanylidene-3-sulfanylidene-propan-2-yl]amino]-6-oxidanylidene-hexanoic acid, FE (III) ION, Isopenicillin N synthase, ... 著者 Rabe, P, Schofield, C.J. 登録日 2023-07-25 公開日 2024-08-07 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Isopenicillin N synthase in complex with Fe, O2, ACdV or thioaldehyde after 4s O2 exposure To Be Published

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