6DW7

SAMHD1 without Catalytic Nucleotides

Summary for 6DW7

Entry DOI	10.2210/pdb6dw7/pdb
Descriptor	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ... (8 entities in total)
Functional Keywords	complex, deoxynucleoside triphosphate triphosphohydrolase, dntpase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	258174.24
Authors	Knecht, K.M.,Buzovetsky, O.,Schneider, C.,Thomas, D.,Srikanth, V.,Kaderali, L.,Tofoleanu, F.,Reiss, K.,Ferreiros, N.,Geisslinger, G.,Batista, V.S.,Ji, X.,Cinatl, J.,Keppler, O.T.,Xiong, Y. (deposition date: 2018-06-26, release date: 2018-10-10, Last modification date: 2024-03-13)
Primary citation	Knecht, K.M.,Buzovetsky, O.,Schneider, C.,Thomas, D.,Srikanth, V.,Kaderali, L.,Tofoleanu, F.,Reiss, K.,Ferreiros, N.,Geisslinger, G.,Batista, V.S.,Ji, X.,Cinatl Jr., J.,Keppler, O.T.,Xiong, Y. The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1. Proc. Natl. Acad. Sci. U.S.A., 115:E10022-E10031, 2018 Cited by PubMed: 30305425 DOI: 10.1073/pnas.1805593115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation