6DW7
SAMHD1 without Catalytic Nucleotides
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | binding site for residue DTP A 701 |
Chain | Residue |
A | ARG333 |
B | MG701 |
B | GTP702 |
C | VAL156 |
C | PHE157 |
C | ARG372 |
C | HIS376 |
C | LYS377 |
C | VAL378 |
A | PHE337 |
A | ARG352 |
A | LYS354 |
A | ASN358 |
A | LYS523 |
B | VAL117 |
B | ASN119 |
B | HIS125 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue MG A 702 |
Chain | Residue |
A | LYS116 |
A | GTP703 |
B | DTP703 |
site_id | AC3 |
Number of Residues | 15 |
Details | binding site for residue GTP A 703 |
Chain | Residue |
A | LYS116 |
A | VAL117 |
A | ILE118 |
A | ILE136 |
A | ASP137 |
A | GLN142 |
A | ARG145 |
A | PHE165 |
A | MG702 |
B | LYS523 |
B | DTP703 |
D | TYR155 |
D | VAL156 |
D | VAL378 |
D | ARG451 |
site_id | AC4 |
Number of Residues | 1 |
Details | binding site for residue GLY A 704 |
Chain | Residue |
A | GLY508 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue NA A 705 |
Chain | Residue |
A | ASP311 |
A | LYS312 |
A | HOH810 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue NA A 706 |
Chain | Residue |
A | THR114 |
A | LYS116 |
A | HOH814 |
site_id | AC7 |
Number of Residues | 2 |
Details | binding site for residue MG B 701 |
Chain | Residue |
A | DTP701 |
B | GTP702 |
site_id | AC8 |
Number of Residues | 16 |
Details | binding site for residue GTP B 702 |
Chain | Residue |
A | LYS523 |
A | DTP701 |
B | LYS116 |
B | VAL117 |
B | ILE118 |
B | ASP137 |
B | GLN142 |
B | ARG145 |
B | PHE165 |
B | MG701 |
B | HOH813 |
C | TYR155 |
C | VAL156 |
C | VAL378 |
C | ARG451 |
C | LYS455 |
site_id | AC9 |
Number of Residues | 17 |
Details | binding site for residue DTP B 703 |
Chain | Residue |
A | VAL117 |
A | ASN119 |
A | MG702 |
A | GTP703 |
B | ARG333 |
B | PHE337 |
B | ARG352 |
B | LYS354 |
B | ASN358 |
B | LYS523 |
B | HOH811 |
D | VAL156 |
D | PHE157 |
D | ARG372 |
D | HIS376 |
D | LYS377 |
D | VAL378 |
site_id | AD1 |
Number of Residues | 15 |
Details | binding site for residue DTP C 701 |
Chain | Residue |
A | VAL156 |
A | PHE157 |
A | ARG372 |
A | HIS376 |
A | LYS377 |
C | ARG333 |
C | PHE337 |
C | ARG352 |
C | LYS354 |
C | ASN358 |
C | LYS523 |
C | MG702 |
D | VAL117 |
D | ASN119 |
D | GTP701 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue MG C 702 |
Chain | Residue |
C | DTP701 |
D | LYS116 |
D | GTP701 |
site_id | AD3 |
Number of Residues | 3 |
Details | binding site for residue MG C 703 |
Chain | Residue |
C | LYS116 |
C | GTP704 |
D | DTP702 |
site_id | AD4 |
Number of Residues | 15 |
Details | binding site for residue GTP C 704 |
Chain | Residue |
B | VAL156 |
B | VAL378 |
B | ARG451 |
C | LYS116 |
C | VAL117 |
C | ILE118 |
C | ILE136 |
C | ASP137 |
C | GLN142 |
C | ARG145 |
C | PHE165 |
C | MG703 |
D | LYS523 |
D | DTP702 |
B | TYR155 |
site_id | AD5 |
Number of Residues | 2 |
Details | binding site for residue GLY C 705 |
Chain | Residue |
C | LYS312 |
C | ARG366 |
site_id | AD6 |
Number of Residues | 6 |
Details | binding site for residue NA C 706 |
Chain | Residue |
C | TYR507 |
C | GLY508 |
C | MET509 |
C | GLN510 |
C | LYS512 |
C | PHE545 |
site_id | AD7 |
Number of Residues | 16 |
Details | binding site for residue GTP D 701 |
Chain | Residue |
A | TYR155 |
A | VAL156 |
A | VAL378 |
A | ARG451 |
A | LEU453 |
C | LYS523 |
C | DTP701 |
C | MG702 |
D | LYS116 |
D | VAL117 |
D | ILE118 |
D | ILE136 |
D | ASP137 |
D | GLN142 |
D | ARG145 |
D | PHE165 |
site_id | AD8 |
Number of Residues | 15 |
Details | binding site for residue DTP D 702 |
Chain | Residue |
B | VAL156 |
B | PHE157 |
B | ARG372 |
B | HIS376 |
B | LYS377 |
C | VAL117 |
C | ASN119 |
C | MG703 |
C | GTP704 |
D | ARG333 |
D | PHE337 |
D | ARG352 |
D | LYS354 |
D | ASN358 |
D | LYS523 |
site_id | AD9 |
Number of Residues | 3 |
Details | binding site for residue PO4 D 703 |
Chain | Residue |
D | LYS312 |
D | TYR315 |
D | ARG366 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:22056990 |
Chain | Residue | Details |
A | HIS233 | |
B | HIS233 | |
C | HIS233 | |
D | HIS233 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: in other chain => ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:25267621, ECO:0000269|PubMed:25288794, ECO:0000269|PubMed:25760601, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200 |
Chain | Residue | Details |
A | LYS116 | |
B | ARG352 | |
B | ASN358 | |
B | LYS523 | |
C | LYS116 | |
C | ASP137 | |
C | ARG333 | |
C | ARG352 | |
C | ASN358 | |
C | LYS523 | |
D | LYS116 | |
A | ASP137 | |
D | ASP137 | |
D | ARG333 | |
D | ARG352 | |
D | ASN358 | |
D | LYS523 | |
A | ARG333 | |
A | ARG352 | |
A | ASN358 | |
A | LYS523 | |
B | LYS116 | |
B | ASP137 | |
B | ARG333 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:25267621, ECO:0000269|PubMed:25288794, ECO:0000269|PubMed:25760601, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200 |
Chain | Residue | Details |
A | ASN119 | |
B | LYS455 | |
C | ASN119 | |
C | HIS376 | |
C | LYS377 | |
C | ARG451 | |
C | LYS455 | |
D | ASN119 | |
D | HIS376 | |
D | LYS377 | |
D | ARG451 | |
A | HIS376 | |
D | LYS455 | |
A | LYS377 | |
A | ARG451 | |
A | LYS455 | |
B | ASN119 | |
B | HIS376 | |
B | LYS377 | |
B | ARG451 |
site_id | SWS_FT_FI4 |
Number of Residues | 32 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24141705 |
Chain | Residue | Details |
A | GLN149 | |
B | ARG164 | |
B | HIS210 | |
B | ASP309 | |
B | TYR315 | |
B | ASP319 | |
B | ARG366 | |
B | HIS370 | |
C | GLN149 | |
C | ARG164 | |
C | HIS210 | |
A | ARG164 | |
C | ASP309 | |
C | TYR315 | |
C | ASP319 | |
C | ARG366 | |
C | HIS370 | |
D | GLN149 | |
D | ARG164 | |
D | HIS210 | |
D | ASP309 | |
D | TYR315 | |
A | HIS210 | |
D | ASP319 | |
D | ARG366 | |
D | HIS370 | |
A | ASP309 | |
A | TYR315 | |
A | ASP319 | |
A | ARG366 | |
A | HIS370 | |
B | GLN149 |
site_id | SWS_FT_FI5 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:25288794, ECO:0000269|PubMed:25760601, ECO:0000269|PubMed:26431200 |
Chain | Residue | Details |
A | HIS167 | |
C | ARG206 | |
C | ASN207 | |
C | ASP311 | |
D | HIS167 | |
D | ARG206 | |
D | ASN207 | |
D | ASP311 | |
A | ARG206 | |
A | ASN207 | |
A | ASP311 | |
B | HIS167 | |
B | ARG206 | |
B | ASN207 | |
B | ASP311 | |
C | HIS167 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | THR592 | |
B | THR592 | |
C | THR592 | |
D | THR592 |
site_id | SWS_FT_FI7 |
Number of Residues | 20 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS467 | |
B | LYS622 | |
C | LYS467 | |
C | LYS469 | |
C | LYS492 | |
C | LYS622 | |
D | LYS467 | |
D | LYS469 | |
D | LYS492 | |
D | LYS622 | |
A | LYS469 | |
A | LYS492 | |
A | LYS622 | |
B | LYS467 | |
B | LYS469 | |
B | LYS492 |