PDB: 217686 件ウェブページステータス検索Chemie searchBIRD

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7ECR	Crystal Structure of Aspergillus terreus Glutamate Dehydrogenase (AtGDH) Complexed With Succinate and ADP-ribose 分子名称: GLYCEROL, Glutamate dehydrogenase, SUCCINIC ACID, ... 著者 Godsora, B.K.J, Prakash, P, Punekar, N.S, Bhaumik, P. 登録日 2021-03-13 公開日 2021-12-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Molecular insights into the inhibition of glutamate dehydrogenase by the dicarboxylic acid metabolites. Proteins, 90, 2022
6M81	Crystal structure of TylM1 Y14F bound to SAH and dTDP-phenol 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phenoxy)phosphoryl]oxy}phosphoryl]thymidine, S-ADENOSYL-L-HOMOCYSTEINE, dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase 著者 Fick, R.J, McDole, B.G, Trievel, R.C. 登録日 2018-08-21 公開日 2019-03-13 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.782 Å) 主引用文献 Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1. Biochemistry, 58, 2019
7K5V	OXA-48 bound by Compound 3.1 分子名称: 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... 著者 Taylor, D.M, Hu, L, Prasad, B.V.V, Palzkill, T. 登録日 2020-09-17 公開日 2021-12-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48. Acs Infect Dis., 7, 2021
6U8O	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction 分子名称: 5-bromo-N-[5-(1-cyanocyclobutyl)-2-hydroxyphenyl]-2-hydroxybenzene-1-sulfonamide, WD repeat-containing protein 5 著者 Zhao, B, Wang, F. 登録日 2019-09-05 公開日 2019-12-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
5KPO	Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor 分子名称: 1-[[3-(4-ethyl-3-oxidanylidene-piperazin-1-yl)carbonyl-4-fluoranyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1 著者 Cao, R, Wang, Y.L, Zhou, J, Yao, H.P, Huang, N, Xu, B.L. 登録日 2016-07-05 公開日 2016-12-21 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor To Be Published
6EKP	Tryptophan Repressor TrpR from E.coli variant T44L T81M S88Y with Indole-3-acetic acid as ligand 分子名称: 1H-INDOL-3-YLACETIC ACID, 3,6,9,12,15-PENTAOXAHEPTADECANE, Trp operon repressor 著者 Stiel, A.C, Shanmugaratnam, S, Herud-Sikimic, O, Juergens, G, Hocker, B. 登録日 2017-09-26 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 A biosensor for the direct visualization of auxin Nature, 2021
5E6B	Glucocorticoid receptor DNA binding domain - RELB NF-kB response element complex 分子名称: DNA (5'-D(*CP*CP*GP*GP*GP*GP*AP*AP*TP*TP*CP*CP*GP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*CP*GP*GP*AP*AP*TP*TP*CP*CP*CP*CP*GP*G)-3'), Glucocorticoid receptor, ... 著者 Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A. 登録日 2015-10-09 公開日 2017-02-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements. Nat Commun, 9, 2018
5KYC	Crystal structure of USP7 catalytic domain [V302K] mutant in complex with ubiquitin (malonate bound) 分子名称: GLYCEROL, MALONIC ACID, Polyubiquitin-B, ... 著者 Rouge, L, Ozen, A. 登録日 2016-07-21 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.426 Å) 主引用文献 Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation. Structure, 26, 2018
5E8P	The structure of the TEIPP associated altered peptide ligand Trh4-p5NLE in complex with H-2D(b) 分子名称: Beta-2-microglobulin, Ceramide synthase 5, H-2 class I histocompatibility antigen, ... 著者 Hafstrand, I, Doorduijn, E, Duru, A.D, Buratto, J, Oliveira, C.C, Sandalova, T, van Hall, T, Achour, A. 登録日 2015-10-14 公開日 2016-02-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer. J Immunol., 196, 2016
5ZZ1	Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum 分子名称: 3-AMINO-1,2,4-TRIAZOLE, CALCIUM ION, CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE, ... 著者 Yuzugullu Karakus, Y, Trinh, C.H, Pearson, A.R, Ogel, Z.B, McPherson, M.J. 登録日 2018-05-29 公開日 2019-05-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Identification of the site of oxidase substrate binding in Scytalidium thermophilum catalase. Acta Crystallogr D Struct Biol, 74, 2018
6UIG	Crystal structure of human monoclonal antibody H7.200 in complex with H7N9 hemagglutinin HA1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, H7.200 Fab heavy chain, H7.200 Fab light chain, ... 著者 Dong, J, Crowe, J.E. 登録日 2019-09-30 公開日 2020-10-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface. J.Clin.Invest., 130, 2020
5I9B	Caspase 3 V266A 分子名称: ACE-ASP-GLU-VAL-ASK, Caspase-3, SODIUM ION 著者 Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. 登録日 2016-02-19 公開日 2016-10-26 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
6LW2	The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase 分子名称: 7-chloranyl-4-[(3-methoxyphenyl)amino]-N-(4-methoxyphenyl)sulfonyl-1-methyl-indole-2-carboxamide, Fructose-1,6-bisphosphatase 1 著者 Wang, X.Y, Zhou, J, Xu, B.L. 登録日 2020-02-07 公開日 2020-05-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of N -Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis. J.Med.Chem., 63, 2020
8P3D	Full length structure of TcMIP with bound inhibitor NJS224. 分子名称: (2~{S})-1-[(4-fluorophenyl)methylsulfonyl]-~{N}-[(2~{S})-4-methyl-1-oxidanylidene-1-(pyridin-3-ylmethylamino)pentan-2-yl]piperidine-2-carboxamide, SODIUM ION, peptidylprolyl isomerase 著者 Whittaker, J.J, Guskov, A, Goretzki, B, Hellmich, U.A. 登録日 2023-05-17 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Structural dynamics of macrophage infectivity potentiator proteins (MIPs) are differentially modulated by inhibitors and appendage domains To Be Published
5IBC	Caspase 3 V266I 分子名称: ACE-ASP-GLU-VAL-ASK, Caspase-3, SODIUM ION 著者 Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. 登録日 2016-02-22 公開日 2016-10-26 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
7KMG	LY-CoV555 neutralizing antibody against SARS-CoV-2 分子名称: GLYCEROL, LY-CoV555 Fab heavy chain, LY-CoV555 Fab light chain, ... 著者 Hendle, J, Pustilnik, A, Sauder, J.M, Coleman, K.A, Boyles, J.S, Dickinson, C.D. 登録日 2020-11-02 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates. Sci Transl Med, 13, 2021
1P8K	The structure and DNA recognition of a bifunctional homing endonuclease and group I intron splicing factor 分子名称: 5'-D(P*CP*CP*TP*CP*CP*TP*CP*AP*GP*CP*GP*CP*GP*CP*T)-3', 5'-D(P*GP*CP*GP*CP*GP*CP*TP*GP*AP*GP*GP*AP*GP*GP*TP*TP*TP*C)-3', 5'-D(P*GP*CP*GP*CP*TP*TP*TP*AP*CP*AP*GP*AP*GP*AP*AP*A)-3', ... 著者 Stoddard, B.L, Bolduc, J.M. 登録日 2003-05-07 公開日 2004-01-20 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor. Genes Dev., 17, 2003
5IBN	Ultra high resolution crystal structure of the apo- form of second bromodomain of BRD2. 分子名称: Bromodomain-containing protein 2, CHLORIDE ION, GLYCEROL, ... 著者 Tripathi, S.K, Padmanabhan, B. 登録日 2016-02-22 公開日 2016-06-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (0.94 Å) 主引用文献 A Novel Phenanthridionone Based Scaffold As a Potential Inhibitor of the BRD2 Bromodomain: Crystal Structure of the Complex Plos One, 11, 2016
5KW9	Structural Basis for Norovirus Neutralization by a HBGA Blocking Human IgA Antibody 分子名称: Capsid protein VP1, IgA Light chain, IgA(VH)-IgG(CH) heavy chain Fab fragment, ... 著者 Shanker, S, Prasad, B.V.V. 登録日 2016-07-15 公開日 2016-10-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody. Proc.Natl.Acad.Sci.USA, 113, 2016
5DUY	Structure of lectin from the sea mussel Crenomytilus grayanus 分子名称: GLYCEROL, GalNAc/Gal-specific lectin 著者 Lubkowski, J, Jakob, M, O'Keefe, B, Wlodawer, A. 登録日 2015-09-21 公開日 2015-11-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Structure of a lectin from the sea mussel Crenomytilus grayanus (CGL). Acta Crystallogr.,Sect.F, 71, 2015
8P42	Full length structure of TcMIP with bound inhibitor NJS227. 分子名称: (2~{S})-1-[(4-fluorophenyl)methylsulfonyl]-~{N}-[(2~{S})-3-(4-fluorophenyl)-1-oxidanylidene-1-(pyridin-3-ylmethylamino)propan-2-yl]piperidine-2-carboxamide, DI(HYDROXYETHYL)ETHER, Macrophage infectivity potentiator 著者 Whittaker, J.J, Guskov, A, Goretzki, B, Hellmich, U.A. 登録日 2023-05-19 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 Structural dynamics of macrophage infectivity potentiator proteins (MIPs) are differentially modulated by inhibitors and appendage domains To Be Published
5IBP	Caspase 3 V266M 分子名称: ACE-ASP-GLU-VAL-ASK, AZIDE ION, Caspase-3 著者 Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. 登録日 2016-02-22 公開日 2016-10-26 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
5IFR	Structure of the stable UBE2D3-UbDha conjugate 分子名称: GLYCEROL, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D3 著者 Pruneda, J.N, Mulder, M.P.C, Witting, K, Ovaa, H, Komander, D. 登録日 2016-02-26 公開日 2016-05-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes. Nat.Chem.Biol., 12, 2016
4WLI	Stationary Phase Survival Protein YuiC from B.subtilis 分子名称: 1,2-ETHANEDIOL, YuiC 著者 Quay, D.H.X, Cole, A.R, Cryar, A, Thalassinos, K, Williams, M.A, Bhakta, S, Keep, N.H. 登録日 2014-10-07 公開日 2015-07-08 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Structure of the stationary phase survival protein YuiC from B.subtilis. Bmc Struct.Biol., 15, 2015
8F7H	The condensation domain of surfactin A synthetase C variant 18b in space group P212121 分子名称: GLYCEROL, Surfactin synthetase 著者 Frota, N.F, Pistofidis, A, Folger, I.B, Hilvert, D, Schmeing, M. 登録日 2022-11-18 公開日 2023-11-22 最終更新日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 High-throughput reprogramming of an NRPS condensation domain. Nat.Chem.Biol., 20, 2024

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