7QR5
 
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7QQO
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7QQP
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7QQQ
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7QQS
 | | SpCas9 bound to FANCF on-target DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, FANCF on-target non-target strand, FANCF on-target target strand, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-01-10 | | 公開日 | 2022-10-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for Cas9 off-target activity.
Cell, 185, 2022
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7QQU
 | | SpCas9 bound to FANCF off-target2 DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target2 non-target strand, FANCF off-target2 target strand, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-01-10 | | 公開日 | 2022-10-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structural basis for Cas9 off-target activity.
Cell, 185, 2022
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7QQT
 | | SpCas9 bound to FANCF off-target1 DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target1 non-target strand, FANCF off-target1 target strand, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-01-10 | | 公開日 | 2022-10-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis for Cas9 off-target activity.
Cell, 185, 2022
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7QR8
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7QQX
 | | SpCas9 bound to FANCF off-target5 DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target5 non-target strand, FANCF off-target5 target strand, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-01-10 | | 公開日 | 2022-10-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for Cas9 off-target activity.
Cell, 185, 2022
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7QR0
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7QQZ
 | | SpCas9 bound to FANCF off-target7 DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target7 non-target strand, FANCF off-target7 target strand, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-01-10 | | 公開日 | 2022-10-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural basis for Cas9 off-target activity.
Cell, 185, 2022
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7QQW
 | | SpCas9 bound to FANCF off-target4 DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target4 non-target strand, FANCF off-target4 target strand, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-01-10 | | 公開日 | 2022-10-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural basis for Cas9 off-target activity.
Cell, 185, 2022
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7QR1
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7QR7
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8FZ4
 | | The von Willebrand factor A domain of Anthrax toxin receptor 2 | | 分子名称: | Anthrax toxin receptor 2, CHLORIDE ION, MAGNESIUM ION | | 著者 | Pedroza-Romo, M.J, Soleimani, S, Lewis, A, Smith, T, Brown, S, Doukov, T, Moody, J.D. | | 登録日 | 2023-01-27 | | 公開日 | 2023-03-01 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Increasing the bulk of the 1TEL-target linker and retaining the 10×His tag in a 1TEL-CMG2-vWa construct improves crystal order and diffraction limits.
Acta Crystallogr D Struct Biol, 79, 2023
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7QDA
 | | Crystal structure of CalpL | | 分子名称: | CalpL, SULFATE ION, TETRAETHYLENE GLYCOL, ... | | 著者 | Schneberger, N, Hagelueken, G. | | 登録日 | 2021-11-26 | | 公開日 | 2022-11-16 | | 最終更新日 | 2023-02-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Antiviral signalling by a cyclic nucleotide activated CRISPR protease.
Nature, 614, 2023
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1RMZ
 | | Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor NNGH at 1.3 A resolution | | 分子名称: | CALCIUM ION, Macrophage metalloelastase, N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID, ... | | 著者 | Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Mangani, S, Terni, B. | | 登録日 | 2003-11-28 | | 公開日 | 2004-12-14 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Conformational variability of matrix metalloproteinases: beyond a single 3D structure.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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4ACM
 | | CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE | | 分子名称: | 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE, CYCLIN-DEPENDENT KINASE 2, GLYCEROL | | 著者 | Berg, S, Bhat, R, Anderson, M, Bergh, M, Brassington, C, Hellberg, S, Jerning, E, Hogdin, K, Lo-Alfredsson, Y, Neelissen, J, Nilsson, Y, Ormo, M, Soderman, P, Stanway, J, Tucker, J, von Berg, S, Weigelt, T, Xue, Y. | | 登録日 | 2011-12-16 | | 公開日 | 2012-05-16 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | Discovery of novel potent and highly selective glycogen synthase kinase-3 beta (GSK3 beta ) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines.
J. Med. Chem., 55, 2012
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8T3X
 | | TNA polymerase, closed ternary | | 分子名称: | 10-92, TNA polymerase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Maola, V, Chaput, J, Chim, N. | | 登録日 | 2023-06-07 | | 公開日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | | 主引用文献 | Directed Evolution of a Highly Efficient TNA Polymerase Achieved by Homologous Recombination
To Be Published
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7QSP
 | | Permutated C-terminal lobe of the ribose binding protein from Thermotoga maritima | | 分子名称: | 1,2-ETHANEDIOL, Ribose ABC transporter, periplasmic ribose-binding protein | | 著者 | Shanmugaratnam, S, Michel, F, Hocker, B. | | 登録日 | 2022-01-14 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Structures of permuted halves of a modern ribose-binding protein.
Acta Crystallogr D Struct Biol, 79, 2023
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7QSQ
 | | Permutated N-terminal lobe of the ribose binding protein from Thermotoga maritima | | 分子名称: | 1,2-ETHANEDIOL, Ribose ABC transporter, periplasmic ribose-binding protein, ... | | 著者 | Shanmugaratnam, S, Michel, F, Hocker, B. | | 登録日 | 2022-01-14 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Structures of permuted halves of a modern ribose-binding protein.
Acta Crystallogr D Struct Biol, 79, 2023
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6SRI
 | | Structure of the Fanconi anaemia core complex | | 分子名称: | Fanconi anaemia protein FANCL, Unassigned secondary structure elements (base region, proposed FANCC-FANC-E-FANCF), ... | | 著者 | Shakeel, S, Rajendra, E, Alcon, P, He, S, Scheres, S.H.W, Passmore, L.A. | | 登録日 | 2019-09-05 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structure of the Fanconi anaemia monoubiquitin ligase complex.
Nature, 575, 2019
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8FTT
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8TUI
 | | Crystal structure of Fab-Lirilumab bound to KIR2DL3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Killer cell immunoglobulin-like receptor 2DL3, Lirilumab Fab Heavy Chain, ... | | 著者 | Lorig-Roach, N, DuBois, R.M. | | 登録日 | 2023-08-16 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structural basis for the activity and specificity of the immune checkpoint inhibitor lirilumab.
Sci Rep, 14, 2024
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8UCE
 | | Thermophilic RNA Ligase from Palaeococcus pacificus + AMP | | 分子名称: | ADENOSINE MONOPHOSPHATE, ATP dependent DNA ligase, GLYCEROL, ... | | 著者 | Rousseau, M.D, Hicks, J.L, Oulavallickal, T, Williamson, A, Arcus, V.L, Patrick, M.W. | | 登録日 | 2023-09-26 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus.
Nucleic Acids Res., 52, 2024
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