PDB: 223790 件ウェブページステータス検索Chemie searchBIRD

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9B5E	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class 10 map and model from consensus 分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, Large ribosomal subunit protein eL40B, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
9BRX	SARS-CoV-2 Papain-like Protease (PLpro) with Fragment 10 分子名称: (4R)-N-(2,4-dimethylphenyl)-7-methyl[1,2,4]triazolo[4,3-a]pyrimidin-5-amine, Papain-like protease nsp3, SULFATE ION, ... 著者 Amporndanai, K, Zhao, B, Fesik, S.W. 登録日 2024-05-11 公開日 2024-07-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PLpro) Acs Med.Chem.Lett., 2024
9FBX	C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 5-(1-benzyl-4-chloro-1H-imidazol-2-yl)-1,3-dimethylpyridin-2(1H)-one 分子名称: 1,2-ETHANEDIOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 5-(1-benzyl-4-chloro-1H-imidazol-2-yl)-1,3-dimethylpyridin-2(1H)-one, ... 著者 Chung, C. 登録日 2024-05-14 公開日 2024-06-26 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.602 Å) 主引用文献 Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. J.Med.Chem., 67, 2024
9ATN	NMR structure of the MLL4 PHD2/3 fingers in complex with ASXL2 分子名称: Histone-lysine N-methyltransferase 2D, Polycomb group protein ASXL2, ZINC ION 著者 Zhang, Y, Zandian, M, Kutateladze, T. 登録日 2024-02-27 公開日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers. Nat Commun, 15, 2024
6DR5	X-ray crystallographic structure of a covalent trimer derived from A-beta 17_36 containing the I31Chg point mutation 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ORT-CYS-VAL-PHE-MEA-CYS-GLU-ASP-ORT-ALA-CHG-ILE-GLY-LEU-ORA-VAL 著者 Salveson, P.J, Nowick, J.S. 登録日 2018-06-11 公開日 2018-10-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.079 Å) 主引用文献 Repurposing Triphenylmethane Dyes to Bind to Trimers Derived from A beta. J. Am. Chem. Soc., 140, 2018
9BRA	Intact V-ATPase State 2 and synaptophysin complex in mouse brain isolated synaptic vesicles 分子名称: Renin receptor cytoplasmic fragment, Ribonuclease kappa, Synaptophysin, ... 著者 Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. 登録日 2024-05-11 公開日 2024-06-19 最終更新日 2024-08-07 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structure and topography of the synaptic V-ATPase-synaptophysin complex. Nature, 631, 2024
8ZM5	Crystal structure of Thermolysin (Dose II) 分子名称: CALCIUM ION, ISOLEUCINE, LYSINE, ... 著者 Nam, K.H. 登録日 2024-05-22 公開日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal structure of Thermolysin (Dose II) To Be Published
8Z3B	Crystal structure of GSTd2 分子名称: Glutathione S-transferase delta 著者 Mo, X, Yao, Y. 登録日 2024-04-15 公開日 2024-07-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Characterization of a Plutella xylostella GZTd2, evolved in isothiocyanate detoxification To be published
9F99	Crystal structure of MUS81-EME1 bound by compound 10. 分子名称: 2-(4-chlorophenyl)-5-oxidanyl-6-oxidanylidene-1H-pyrimidine-4-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ... 著者 Collie, G.W. 登録日 2024-05-07 公開日 2024-06-19 最終更新日 2024-07-31 実験手法 X-RAY DIFFRACTION (2.803 Å) 主引用文献 Fragment-Based Discovery of Novel MUS81 Inhibitors. Acs Med.Chem.Lett., 15, 2024
9B58	Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 4 分子名称: 4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 最終更新日 2024-08-14 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway Nature, 2024
8Z50	Crystal structure of the ASF1-H3T-H4 complex 分子名称: Histone H3.1t, Histone H4, Histone chaperone ASF1A 著者 Xu, L. 登録日 2024-04-18 公開日 2024-07-03 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural insights into instability of the nucleosome driven by histone variant H3T. Biochem.Biophys.Res.Commun., 727, 2024
9FIH	Crystal Structure of NuoEF variant P228R(NuoF) from Aquifex aeolicus bound to NADH under anoxic conditions after 10 min soaking 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, FE2/S2 (INORGANIC) CLUSTER, ... 著者 Wohlwend, D, Friedrich, T, Goeppert-Asadollahpour, S. 登録日 2024-05-29 公開日 2024-07-17 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I). Biochim Biophys Acta Bioenerg, 1865, 2024
6DJO	Cryo-EM structure of ADP-actin filaments 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... 著者 Chou, S.Z, Pollard, T.D. 登録日 2018-05-25 公開日 2019-02-27 最終更新日 2024-04-10 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Mechanism of actin polymerization revealed by cryo-EM structures of actin filaments with three different bound nucleotides. Proc.Natl.Acad.Sci.USA, 116, 2019
9EOW	The 5-terminal stem-loop RNA element of SARS-CoV-2 features highly dynamic structural elements that are sensitive to differences in cellular pH 分子名称: RNA (29-MER) 著者 Wacker, A, Schwalbe, H. 登録日 2024-03-15 公開日 2024-06-19 最終更新日 2024-07-31 実験手法 SOLUTION NMR 主引用文献 The 5'-terminal stem-loop RNA element of SARS-CoV-2 features highly dynamic structural elements that are sensitive to differences in cellular pH. Nucleic Acids Res., 52, 2024
9B5I	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 4 map and model (Ub(A)-AMP/PPi/Mg) 分子名称: 4-aminobutanenitrile, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
9BB4	Backbone Modification in the GA Module of Protein PAB: beta3-residues at positions 23 and 26 分子名称: Peptostreptococcal albumin-binding protein 著者 Lin, Y, Horne, W.S. 登録日 2024-04-05 公開日 2024-06-05 実験手法 SOLUTION NMR 主引用文献 Backbone Modification in a Protein Hydrophobic Core. Chemistry, 2024
9F9M	Crystal structure of MUS81-EME1 bound by compound 21. 分子名称: 5-oxidanyl-4-oxidanylidene-1-(4-piperazin-1-ylphenyl)pyridine-3-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ... 著者 Collie, G.W. 登録日 2024-05-08 公開日 2024-06-19 最終更新日 2024-07-31 実験手法 X-RAY DIFFRACTION (2.469 Å) 主引用文献 Fragment-Based Discovery of Novel MUS81 Inhibitors. Acs Med.Chem.Lett., 15, 2024
8ZWH	Heparin bound E46K alpha-synuclein fibril 分子名称: Alpha-synuclein 著者 Tao, Y.Q, Liu, C, Li, D. 登録日 2024-06-13 公開日 2024-07-03 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Heparin bound E46K alpha-synuclein fibril To Be Published
8YXO	Structure of Phosphoprotein tetramer from mumps virus 分子名称: Phosphoprotein 著者 Li, T.H, Shen, Q.T. 登録日 2024-04-02 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.49 Å) 主引用文献 Structures of the mumps virus polymerase complex via cryo-electron microscopy. Nat Commun, 15, 2024
9C0B	E.coli GroEL + PBZ1587 inhibitor 分子名称: 60 kDa chaperonin, N-(2-{4-[4-(aminomethyl)benzene-1-sulfonamido]phenyl}-1,3-benzoxazol-5-yl)-5-chlorothiophene-2-sulfonamide 著者 Watson, E.R, Lander, G.C. 登録日 2024-05-25 公開日 2024-08-07 最終更新日 2024-08-14 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Bis-sulfonamido-2-phenylbenzoxazoles Validate the GroES/EL Chaperone System as a Viable Antibiotic Target. J.Am.Chem.Soc., 146, 2024
6DUQ	Structure of a Rho-NusG KOW domain complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... 著者 Berger, J.M, Lawson, M.R. 登録日 2018-06-21 公開日 2018-09-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein. Mol. Cell, 71, 2018
6DLM	DHD127 分子名称: DHD127_A, DHD127_B 著者 Bick, M.J, Chen, Z, Baker, D. 登録日 2018-06-01 公開日 2018-12-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.753 Å) 主引用文献 Programmable design of orthogonal protein heterodimers. Nature, 565, 2019
9C0Z	Clathrin terminal domain complexed with pitstop 2d 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ... 著者 Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V. 登録日 2024-05-28 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Acute inhibition of clathrin-mediated endocytosis by next-generation small molecule inhibitors of clathrin function To Be Published
9BBH	Co-crystal structure of human DDB1 bound to fragment UB028670 分子名称: 1,2-ETHANEDIOL, 4-methoxy-1H-indole, DNA damage-binding protein 1, ... 著者 Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) 登録日 2024-04-05 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Co-crystal structure of human DDB1 bound to fragment UB028670 To be published
9FEA	Crystal Structure of reduced NuoEF variant P228R(NuoF) from Aquifex aeolicus bound to NAD+ 分子名称: 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, ... 著者 Wohlwend, D, Friedrich, T, Goeppert-Asadollahpour, S. 登録日 2024-05-17 公開日 2024-07-17 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I). Biochim Biophys Acta Bioenerg, 1865, 2024

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