6DR5
X-ray crystallographic structure of a covalent trimer derived from A-beta 17_36 containing the I31Chg point mutation
Summary for 6DR5
| Entry DOI | 10.2210/pdb6dr5/pdb |
| Descriptor | ORT-CYS-VAL-PHE-MEA-CYS-GLU-ASP-ORT-ALA-CHG-ILE-GLY-LEU-ORA-VAL, (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total) |
| Functional Keywords | amyloid, alzheimers disease, abeta, oligomer, de novo protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 6 |
| Total formula weight | 11221.82 |
| Authors | Salveson, P.J.,Nowick, J.S. (deposition date: 2018-06-11, release date: 2018-10-17, Last modification date: 2023-11-15) |
| Primary citation | Salveson, P.J.,Haerianardakani, S.,Thuy-Boun, A.,Yoo, S.,Kreutzer, A.G.,Demeler, B.,Nowick, J.S. Repurposing Triphenylmethane Dyes to Bind to Trimers Derived from A beta. J. Am. Chem. Soc., 140:11745-11754, 2018 Cited by PubMed: 30125493DOI: 10.1021/jacs.8b06568 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.079 Å) |
Structure validation
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