3MNV
 
 | | Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment | | 分子名称: | 1,2-ETHANEDIOL, ANTI-HIV-1 ANTIBODY 13H11 HEAVY CHAIN, ANTI-HIV-1 ANTIBODY 13H11 LIGHT CHAIN, ... | | 著者 | Nicely, N.I, Dennison, S.M, Kelsoe, G, Liao, H.-X, Alam, S.M, Haynes, B.F. | | 登録日 | 2010-04-22 | | 公開日 | 2010-11-17 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region.
Nat.Struct.Mol.Biol., 17, 2010
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6CUG
 | | Crystal structure of BC8B TCR-CD1b-PC complex | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | | 著者 | Shahine, A.E, Rossjohn, J. | | 登録日 | 2018-03-26 | | 公開日 | 2019-01-16 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.
Nat Commun, 10, 2019
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1R3I
 | | potassium channel KcsA-Fab complex in Rb+ | | 分子名称: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | | 著者 | Zhou, Y, MacKinnon, R. | | 登録日 | 2003-10-02 | | 公開日 | 2003-11-25 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates
J.Mol.Biol., 333, 2003
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3KYN
 | | Crystal structure of HLA-G presenting KGPPAALTL peptide | | 分子名称: | Beta-2-microglobulin, CHLORIDE ION, COBALT (II) ION, ... | | 著者 | Walpole, N.G, Rossjohn, J, Clements, C.S. | | 登録日 | 2009-12-06 | | 公開日 | 2010-02-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The structure and stability of the monomorphic HLA-G are influenced by the nature of the bound peptide
J.Mol.Biol., 397, 2010
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6CX5
 | | Structure of alpha-GSA[8,8P] bound by CD1d and in complex with the Va14Vb8.2 TCR | | 分子名称: | (5R,6S,7S)-5,6-dihydroxy-7-(octanoylamino)-N-(8-phenyloctyl)-8-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octanamide (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wang, J, Zajonc, D. | | 登録日 | 2018-04-02 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | A molecular switch in mouse CD1d modulates natural killer T cell activation by alpha-galactosylsphingamides.
J.Biol.Chem., 294, 2019
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4OGX
 | | Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.4 Angstrom resolution | | 分子名称: | DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, Plasma kallikrein, ... | | 著者 | Edwards, T.E, Clifton, M.C, Abendroth, J, Nixon, A, Ladner, R. | | 登録日 | 2014-01-16 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Inhibition of plasma kallikrein by a highly specific active site blocking antibody.
J.Biol.Chem., 289, 2014
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3MRH
 | | Crystal Structure of MHC class I HLA-A2 molecule complexed with HCV NS3-1073-1081 nonapeptide N3S variant | | 分子名称: | 9-meric peptide from Serine protease/NTPase/helicase NS3, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | | 著者 | Gras, S, Reiser, J.-B, Chouquet, A, Le Gorrec, M, Debeaupuis, E, Echasserieau, K, Saulquin, X, Bonneville, M, Housset, D. | | 登録日 | 2010-04-29 | | 公開日 | 2011-05-25 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Analysis of Relationships between Peptide/MHC Structural Features and Naive T Cell Frequency in Humans.
J.Immunol., 193, 2014
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7UMG
 | | Crystal structure of human CD8aa-MR1-Ac-6-FP complex | | 分子名称: | Beta-2-microglobulin, CHLORIDE ION, Major histocompatibility complex class I-related gene protein, ... | | 著者 | Awad, W, Rossjohn, J. | | 登録日 | 2022-04-06 | | 公開日 | 2022-08-03 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells.
J.Exp.Med., 219, 2022
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5GR7
 | | Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide 37-1 | | 分子名称: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-D alpha chain, ... | | 著者 | Liu, K, Chai, Y, Qi, J, Tan, W, Liu, W.J, Gao, G.F. | | 登録日 | 2016-08-08 | | 公開日 | 2017-06-07 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC.
J. Immunol., 198, 2017
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8SVE
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6IFJ
 | | Structure of bispecific Fc | | 分子名称: | 13-mer peptide, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | 著者 | Qian, X, Lescar, J, Sasisekahran, R. | | 登録日 | 2018-09-20 | | 公開日 | 2019-09-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of bsfc at 2.4 Angstroms resolution
To Be Published
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6BZ4
 | | Human IgG1 lacking complement-dependent cytotoxicity: hu3S193 Fc mutant K322A | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Farrugia, W, Burvenich, I.G.J, Scott, A.M, Ramsland, P.A. | | 登録日 | 2017-12-22 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Global conformational changes in IgG-Fc upon mutation of the FcRn-binding site are not associated with altered antibody-dependent effector functions.
Biochem. J., 475, 2018
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1H3T
 | | Crystal structure of the human igg1 fc-fragment,glycoform (mn2f)2 | | 分子名称: | IG GAMMA-1 CHAIN C REGION, beta-D-mannopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Krapp, S, Mimura, Y, Jefferis, R, Huber, R, Sondermann, P. | | 登録日 | 2002-09-19 | | 公開日 | 2003-01-23 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural Analysis of Human Igg-Fc Glycoforms Reveals a Correlation between Glycosylation and Structural Integrity
J.Mol.Biol., 325, 2003
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8HT1
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1H3U
 | | CRYSTAL STRUCTURE OF THE HUMAN IGG1 FC-FRAGMENT,GLYCOFORM (M3N2F)2 | | 分子名称: | IG GAMMA-1 CHAIN C REGION, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Krapp, S, Mimura, Y, Jefferis, R, Huber, R, Sondermann, P. | | 登録日 | 2002-09-19 | | 公開日 | 2003-01-23 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural Analysis of Human Igg-Fc Glycoforms Reveals a Correlation between Glycosylation and Structural Integrity.
J.Mol.Biol., 325, 2003
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3L3J
 | | Crystal structure of HLA-B*4402 in complex with the F3A/R5A double mutant of a self-peptide derived from DPA*0201 | | 分子名称: | ACETATE ION, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | | 著者 | Theodossis, A, Ely, L.K, Rossjohn, J. | | 登録日 | 2009-12-17 | | 公開日 | 2010-03-16 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition
Proc.Natl.Acad.Sci.USA, 107, 2010
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3I6L
 | | Newly identified epitope N1 derived from SARS-CoV N protein complexed with HLA-A*2402 | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... | | 著者 | Liu, J.W. | | 登録日 | 2009-07-07 | | 公開日 | 2010-07-14 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Novel immunodominant peptide presentation strategy: a featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein
J.Virol., 84, 2010
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5DJ8
 | | Fc Heterodimer Design 7.7 D399M/Y407A + T366V/K409I | | 分子名称: | Fc-III peptide, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Secrist, E, Demarest, S.J, Kuhlman, B. | | 登録日 | 2015-09-01 | | 公開日 | 2016-03-30 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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7AFV
 | | Crystal structure of tetrameric beta-2-microglobulin deltaN6 S52C stabilized by a covalent ligand | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-oxidanylidene-~{N}-(2-sulfanylethyl)-2,3-dihydro-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide, Beta-2-microglobulin | | 著者 | Guthertz, N, Cawood, E, Karamanos, T. | | 登録日 | 2020-09-20 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Modulation of Amyloidogenic Protein Self-Assembly Using Tethered Small Molecules.
J.Am.Chem.Soc., 142, 2020
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7KP0
 | | CD1a-42:1 SM binary complex | | 分子名称: | (4R,7S)-4-hydroxy-7-[(1S,2E)-1-hydroxyhexadec-2-en-1-yl]-N,N,N-trimethyl-4,9-dioxo-3,5-dioxa-8-aza-4lambda~5~-phosphadotriacontan-1-aminium, 1,2-ETHANEDIOL, Beta-2-microglobulin, ... | | 著者 | Wegrecki, M, Le Nours, J, Rossjohn, J. | | 登録日 | 2020-11-10 | | 公開日 | 2021-05-05 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | CD1a selectively captures endogenous cellular lipids that broadly block T cell response.
J.Exp.Med., 218, 2021
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5FA4
 | | Structure of HLA-A2:01 with peptide Y16R | | 分子名称: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | | 著者 | Remesh, S.G, Zajonc, D.M. | | 登録日 | 2015-12-10 | | 公開日 | 2016-12-21 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Unconventional Peptide Presentation by Major Histocompatibility Complex (MHC) Class I Allele HLA-A*02:01: BREAKING CONFINEMENT.
J. Biol. Chem., 292, 2017
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6WNA
 | | Next generation monomeric IgG4 Fc | | 分子名称: | Beta-2-microglobulin, IgG receptor FcRn large subunit p51, Immunoglobulin heavy constant gamma 4, ... | | 著者 | Oganesyan, V.Y, Shan, L, van Dyk, N, Dall'Acqua, W.F. | | 登録日 | 2020-04-22 | | 公開日 | 2021-09-15 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.
Commun Biol, 4, 2021
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7URU
 | | Crystal structure of the low affinity Fc gamma receptor IIIA variant in complex with the Fc of IgG1. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin gamma-1 heavy chain, ... | | 著者 | Tolbert, W.D, Pazgier, M. | | 登録日 | 2022-04-22 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of the low affinity Fc gamma receptor IIIA variant in complex with the Fc of IgG1.
To Be Published
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1LD9
 | | THE THREE-DIMENSIONAL STRUCTURE OF AN H-2LD PEPTIDE COMPLEX EXPLAINS THE UNIQUE INTERACTION OF LD WITH BETA2M AND PEPTIDE | | 分子名称: | BETA-2 MICROGLOBULIN, MHC CLASS I H-2LD HEAVY CHAIN, NANO-PEPTIDE | | 著者 | Balendiran, G.K, Solheim, J.C, Young, A.C.M, Hansen, T.H, Nathenson, S.G, Sacchettini, J.C. | | 登録日 | 1997-04-24 | | 公開日 | 1998-05-06 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide.
Proc.Natl.Acad.Sci.USA, 94, 1997
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5FKA
 | | Crystal structure of staphylococcal enterotoxin E in complex with a T cell receptor | | 分子名称: | STAPHYLOCOCCAL ENTEROTOXIN E, T CELL RECEPTOR ALPHA CHAIN, T CELL RECEPTOR BETA CHAIN, ... | | 著者 | Rodstrom, K.E.J, Regenthal, P, Lindkvist-Petersson, K. | | 登録日 | 2015-10-15 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Two Common Structural Motifs for Tcr Recognition by Staphylococcal Enterotoxins.
Sci.Rep., 6, 2016
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