PDB: 184249 件ウェブページステータス検索Chemie searchBIRD

---

6IAN	T. brucei IFT22/74/81 GTP-bound crystal structure 分子名称: GUANOSINE-5'-TRIPHOSPHATE, Intraflagellar transport protein 74, Intraflagellar transport protein 81, ... 著者 Wachter, S, Basquin, J, Lorentzen, E. 登録日 2018-11-27 公開日 2019-05-01 最終更新日 2019-05-08 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly. Embo J., 38, 2019
1WW2	Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase 分子名称: Glycogen phosphorylase, muscle form, N-acetyl-beta-D-glucopyranosylamine, ... 著者 Anagnostou, E, Kosmopoulou, M.N, Chrysina, E.D, Leonidas, D.D, Hadjiloi, T, Tiraidis, C, Zographos, S.E, Gyorgydeak, Z, Somsak, L, Docsa, T, Gergely, P, Kolisis, F.N, Oikonomakos, N.G. 登録日 2004-12-30 公開日 2005-12-13 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-d-glucopyranosylamine and N-trifluoroacetyl-beta-d-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase Bioorg.Med.Chem., 14, 2006
7S1Y	Cryo-EM structure of human NKCC1 K289NA492E bound with bumetanide 分子名称: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, CHLORIDE ION, POTASSIUM ION, ... 著者 Zhao, Y.X, Cao, E.h. 登録日 2021-09-02 公開日 2022-05-25 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide Nat Commun, 13, 2022
7SBB	Structure of type I-D Cascade bound to a ssRNA target 分子名称: Cas10d, Cas11d, Cas5d, ... 著者 Schwartz, E.A, Taylor, D.W. 登録日 2021-09-24 公開日 2022-06-08 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural rearrangements allow nucleic acid discrimination by type I-D Cascade. Nat Commun, 13, 2022
5BMM	Src in complex with DNA-templated macrocyclic inhibitor MC25b 分子名称: Proto-oncogene tyrosine-protein kinase Src, macrocyclic inhibitor MC25b 著者 Georghiou, G, Guja, K.E, Aleem, S, Kleiner, R.E, Liu, D.R, Miller, W.T, Garcia-Diaz, M, Seeliger, M.A. 登録日 2015-05-22 公開日 2016-09-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles. Cell Chem Biol, 23, 2016
7SBA	Structure of type I-D Cascade bound to a dsDNA target 分子名称: Cas10d, Cas11d, Cas5d, ... 著者 Schwartz, E.A, Taylor, D.W. 登録日 2021-09-24 公開日 2022-06-08 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural rearrangements allow nucleic acid discrimination by type I-D Cascade. Nat Commun, 13, 2022
8TYL	Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein 著者 Bruch, E.M, Rak, A. 登録日 2023-08-25 公開日 2024-02-07 実験手法 ELECTRON MICROSCOPY (2.85 Å) 主引用文献 Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2. Sci Rep, 14, 2024
5BPU	Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I 分子名称: (GGL)EEE, (GGL)EEEEEE, Norrin 著者 Chang, T.-H, Hsieh, F.-L, Harlos, K, Jones, E.Y. 登録日 2015-05-28 公開日 2015-07-01 最終更新日 2019-07-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan. Elife, 4, 2015
2N2A	Spatial structure of HER2/ErbB2 dimeric transmembrane domain in the presence of cytoplasmic juxtamembrane domains 分子名称: Receptor tyrosine-protein kinase erbB-2 著者 Bragin, P.E, Mineev, K.S, Bocharov, E, Bocharova, O, Arseniev, A. 登録日 2015-05-05 公開日 2016-02-24 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 HER2 Transmembrane Domain Dimerization Coupled with Self-Association of Membrane-Embedded Cytoplasmic Juxtamembrane Regions. J.Mol.Biol., 428, 2016
1BB0	THROMBIN INHIBITORS WITH RIGID TRIPEPTIDYL ALDEHYDES 分子名称: 2-{(3S)-3-[(benzylsulfonyl)amino]-2-oxopiperidin-1-yl}-N-{(2S)-1-[(3R)-1-carbamimidoylpiperidin-3-yl]-3-oxopropan-2-yl}acetamide, HIRUGEN, SODIUM ION, ... 著者 Krishnan, R, Zhang, E, Hakansson, K, Arni, R.K, Tulinsky, A, Lim-Wilby, M.S.L, Levy, O.E, Semple, J.E, Brunck, T.K. 登録日 1998-04-28 公開日 1999-04-27 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes. Biochemistry, 37, 1998
2TMN	CRYSTALLOGRAPHIC STRUCTURAL ANALYSIS OF PHOSPHORAMIDATES AS INHIBITORS AND TRANSITION-STATE ANALOGS OF THERMOLYSIN 分子名称: CALCIUM ION, N~2~-phosphono-L-leucinamide, Thermolysin, ... 著者 Tronrud, D.E, Monzingo, A.F, Matthews, B.W. 登録日 1987-06-29 公開日 1989-01-09 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin. Eur.J.Biochem., 157, 1986
7SKS	Crystal structure of measles virus matrix protein 分子名称: Matrix protein 著者 Norris, M.J, Saphire, E.O. 登録日 2021-10-21 公開日 2022-08-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.541 Å) 主引用文献 Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization. Sci Adv, 8, 2022
8CEJ	Succinyl-CoA Reductase from Clostridium kluyveri (SucD) with Mesaconyl-C1-CoA 分子名称: (2E)-2-METHYLBUT-2-ENEDIOIC ACID, Mesaconyl Coenzme A, Succinate-semialdehyde dehydrogenase (acetylating) 著者 Pfister, P, Diehl, C, Erb, T.J. 登録日 2023-02-02 公開日 2023-05-31 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Enhancing the Substrate Specificity of Clostridium Succinyl-CoA Reductase for Synthetic Biology and Biocatalysis. Biochemistry, 62, 2023
6P6E	Structure of Mouse Importin alpha - PAC3 NLS peptide complex 分子名称: Importin subunit alpha-1, PAC3 NLS 著者 Bernardes, N.E, Silva, T.D, Fukuda, C.A, Oliveira, H.C, Fontes, M.R.M. 登録日 2019-06-03 公開日 2020-01-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha. Sci Rep, 10, 2020
5I66	X-ray structure of the Fab fragment of 8B6, a murine monoclonal antibody specific for the human serotonin transporter 分子名称: 8B6 antibody, heavy chain, light chain 著者 Coleman, J.A, Green, E.M, Gouaux, E. 登録日 2016-02-16 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.624 Å) 主引用文献 X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
7RWY	Crystal structure of a Fe-bound RIDC1 variant in the presence of reductant 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FE (III) ION, HEME C, ... 著者 Kakkis, A, Golub, E. 登録日 2021-08-20 公開日 2022-06-29 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Redox- and metal-directed structural diversification in designed metalloprotein assemblies. Chem.Commun.(Camb.), 58, 2022
5EZV	X-ray crystal structure of AMP-activated protein kinase alpha-2/alpha-1 RIM chimaera (alpha-2(1-347)/alpha-1(349-401)/alpha-2(397-end) beta-1 gamma-1) co-crystallized with C2 (5-(5-hydroxyl-isoxazol-3-yl)-furan-2-phosphonic acid) 分子名称: 3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-activated protein kinase catalytic subunit alpha-2/alpha-1 RIM SWAP chimera, 5'-AMP-activated protein kinase subunit beta-1, ... 著者 Langendorf, C.G, Kemp, B.E. 登録日 2015-11-26 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding. Nat Commun, 7, 2016
5AOG	Structure of Sorghum peroxidase 分子名称: 1H-INDOL-3-YLACETIC ACID, CALCIUM ION, CATIONIC PEROXIDASE SPC4, ... 著者 Kwon, H, Nnamchi, C.I, Parkin, G, Efimov, I, Agirre, J, Basran, J, Raven, E.L, Moody, P.C.E. 登録日 2015-09-10 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 Structural and Spectroscopic Characterisation of a Heme Peroxidase from Sorghum. J.Biol.Inorg.Chem., 21, 2016
7SJN	HtrA1:Fab15H6.v4 complex 分子名称: Fab15H6.v4 Heavy Chain, Fab15H6.v4 Light Chain, Serine protease HTRA1 著者 Gerhardy, S, Green, E, Estevez, A, Arthur, C.P, Ultsch, M, Rohou, A, Kirchhofer, D. 登録日 2021-10-18 公開日 2022-09-07 最終更新日 2022-09-21 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration. Nat Commun, 13, 2022
5B34	Serial Femtosecond Crystallography (SFX) of Ground State Bacteriorhodopsin Crystallized from Bicelles in Complex with Iodine-labeled Detergent HAD13a Determined Using 7-keV X-ray Free Electron Laser (XFEL) at SACLA 分子名称: 2,4,6-tris(iodanyl)-5-(octanoylamino)benzene-1,3-dicarboxylic acid, Bacteriorhodopsin, DECANE, ... 著者 Mizohata, E, Nakane, T. 登録日 2016-02-10 公開日 2016-11-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent Proc.Natl.Acad.Sci.USA, 113, 2016
7SKT	Crystal structure of Nipah virus matrix protein 分子名称: Matrix protein 著者 Norris, M.J, Saphire, E.O. 登録日 2021-10-21 公開日 2022-08-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.048 Å) 主引用文献 Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization. Sci Adv, 8, 2022
8TQM	Cryo-EM structure of E3 ubiquitin ligase Doa10 from Saccharomyces cerevisiae 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ERAD-associated E3 ubiquitin-protein ligase DOA10, ... 著者 Park, E, Itskanov, S.I. 登録日 2023-08-07 公開日 2024-03-13 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10. Nat Commun, 15, 2024
6PAX	CRYSTAL STRUCTURE OF THE HUMAN PAX-6 PAIRED DOMAIN-DNA COMPLEX REVEALS A GENERAL MODEL FOR PAX PROTEIN-DNA INTERACTIONS 分子名称: 26 NUCLEOTIDE DNA, HOMEOBOX PROTEIN PAX-6 著者 Xu, H.E, Rould, M.A, Xu, W, Epstein, J.A, Maas, R.L, Pabo, C.O. 登録日 1999-04-22 公開日 1999-07-13 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. Genes Dev., 13, 1999
1O5D	Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA) 分子名称: 2-{5-[AMINO(IMINIO)METHYL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}-6-[(2-METHYLCYCLOHEXYL)OXY]BENZENOLATE, Coagulation factor VII, Tissue factor 著者 Katz, B.A, Luong, C, Ho, J.D, Somoza, J.R, Gjerstad, E, Tang, J, Williams, S.R, Verner, E, Mackman, R.L, Young, W.B, Sprengeler, P.A, Chan, H, Mortara, K, Janc, J.W, McGrath, M.E. 登録日 2003-09-09 公開日 2004-09-21 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA). J.Mol.Biol., 344, 2004
6U9R	MLL1 SET N3861I/Q3867L bound to inhibitor 12 (TC-5140) 分子名称: 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(3-chlorophenyl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase, ZINC ION 著者 Petrunak, E.M, Stuckey, J.A. 登録日 2019-09-09 公開日 2020-07-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase. Acs Med.Chem.Lett., 11, 2020

<597598599600601602603604605606607608609610611612>