7SJN

HtrA1:Fab15H6.v4 complex

Summary for 7SJN

Entry DOI	10.2210/pdb7sjn/pdb
EMDB information	25162
Descriptor	Serine protease HTRA1, Fab15H6.v4 Heavy Chain, Fab15H6.v4 Light Chain (3 entities in total)
Functional Keywords	htra1, allosteric inhibition, age-related macular degeneration, geographic atrophy, antibody complex, hydrolase, hydrolase-immune system complex, hydrolase/immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	9
Total formula weight	140287.61
Authors	Gerhardy, S.,Green, E.,Estevez, A.,Arthur, C.P.,Ultsch, M.,Rohou, A.,Kirchhofer, D. (deposition date: 2021-10-18, release date: 2022-09-07, Last modification date: 2022-09-21)
Primary citation	Gerhardy, S.,Ultsch, M.,Tang, W.,Green, E.,Holden, J.K.,Li, W.,Estevez, A.,Arthur, C.,Tom, I.,Rohou, A.,Kirchhofer, D. Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration. Nat Commun, 13:5222-5222, 2022 Cited by PubMed: 36064790 DOI: 10.1038/s41467-022-32760-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation