PDB: 1955 件ウェブページステータス検索Chemie searchBIRD

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7B3B	Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -3 (structure 1) 分子名称: DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*G)-D(P*(RMP))-R(P*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ... 著者 Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. 登録日 2020-11-30 公開日 2020-12-23 最終更新日 2022-07-27 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12, 2021
7B3C	Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -4 (structure 2) 分子名称: DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*A)-D(P*(RMP))-R(P*GP*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ... 著者 Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. 登録日 2020-11-30 公開日 2020-12-23 最終更新日 2022-07-27 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12, 2021
4RY6	C-terminal mutant (W550A) of HCV/J4 RNA polymerase 分子名称: HCV J4 RNA polymerase (NS5B) 著者 Jaeger, J, Cherry, A, Dennis, C. 登録日 2014-12-13 公開日 2014-12-31 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation. J.Virol., 89, 2015
4RY4	C-terminal mutant (Y448F) of HCV/J4 RNA polymerase 分子名称: HCV J4 RNA polymerase (NS5B) 著者 Jaeger, J, Cherry, A, Dennis, C. 登録日 2014-12-13 公開日 2014-12-31 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation. J.Virol., 89, 2015
4RY7	C-terminal mutant (D559E) of HCV/J4 RNA polymerase 分子名称: HCV J4 RNA polymerase (NS5B) 著者 Jaeger, J, Cherry, A, Dennis, C. 登録日 2014-12-13 公開日 2014-12-31 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation. J.Virol., 89, 2015
4RY5	C-terminal mutant (W550N) of HCV/J4 RNA polymerase 分子名称: HCV J4 RNA polymerase (NS5B), MANGANESE (II) ION, URIDINE 5'-TRIPHOSPHATE 著者 Jaeger, J, Cherry, A, Dennis, C. 登録日 2014-12-13 公開日 2014-12-31 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation. J.Virol., 89, 2015
7BW4	Structure of the RNA-dependent RNA polymerase from SARS-CoV-2 分子名称: Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ... 著者 Peng, Q, Peng, R, Shi, Y. 登録日 2020-04-13 公開日 2020-05-27 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2. Cell Rep, 31, 2020
4NYZ	The EMCV 3Dpol structure with altered motif A conformation at 2.15A resolution 分子名称: GLUTAMINE, GLYCEROL, Genome polyprotein, ... 著者 Vives-adrian, L, Lujan, C, Ferrer-orta, C, Verdaguer, N. 登録日 2013-12-11 公開日 2014-03-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site J.Virol., 88, 2014
4NZ0	The EMCV 3Dpol structure at 2.8A resolution 分子名称: CHLORIDE ION, GLYCEROL, Genome polyprotein 著者 Vives-adrian, L, Ferrer-orta, C, Verdaguer, N. 登録日 2013-12-11 公開日 2014-03-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site J.Virol., 88, 2014
4Y2C	M300V 3D polymerase mutant of EMCV 分子名称: GLYCEROL, Genome polyprotein 著者 Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L. 登録日 2015-02-09 公開日 2015-04-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015
2IJD	Crystal Structure of the Poliovirus Precursor Protein 3CD 分子名称: Picornain 3C, RNA-directed RNA polymerase, SULFATE ION, ... 著者 Marcotte, L.L, Gohara, D.W, Filman, D.J, Hogle, J.M. 登録日 2006-09-29 公開日 2007-02-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Crystal structure of poliovirus 3CD: virally-encoded protease and precursor to the RNA-dependent RNA polymerase. J.Virol., 81, 2007
1RA7	Poliovirus Polymerase with GTP 分子名称: ACETIC ACID, GUANOSINE-5'-TRIPHOSPHATE, Genome polyprotein 著者 Thompson, A.A, Peersen, O.B. 登録日 2003-10-31 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase. Embo J., 23, 2004
1RAJ	Poliovirus Polymerase with a 68 residue N-terminal truncation 分子名称: Genome polyprotein 著者 Thompson, A.A, Peersen, O.B. 登録日 2003-10-31 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase. Embo J., 23, 2004
2R92	Elongation complex of RNA polymerase II with artificial RdRP scaffold 分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... 著者 Lehmann, E, Brueckner, F, Cramer, P. 登録日 2007-09-12 公開日 2007-11-27 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Molecular basis of RNA-dependent RNA polymerase II activity. Nature, 450, 2007
1RA6	Poliovirus Polymerase Full Length Apo Structure 分子名称: ACETIC ACID, Genome polyprotein 著者 Thompson, A.A, Peersen, O.B. 登録日 2003-10-31 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase. Embo J., 23, 2004
7C2K	COVID-19 RNA-dependent RNA polymerase pre-translocated catalytic complex 分子名称: Non-structural protein 7, Non-structural protein 8, RNA (29-MER), ... 著者 Wang, Q, Gao, Y, Ji, W, Mu, A, Rao, Z. 登録日 2020-05-07 公開日 2020-06-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.93 Å) 主引用文献 Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase. Cell, 182, 2020
4KB7	HCV NS5B GT1B N316Y with CMPD 32 分子名称: 5-cyclopropyl-2-(4-fluorophenyl)-6-[{2-[(3R)-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-3-yl]ethyl}(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide, HCV Polymerase 著者 Williams, S.P, Kahler, K.M, Shotwell, J.B. 登録日 2013-04-23 公開日 2013-05-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase. J.Med.Chem., 57, 2014
7D4F	Structure of COVID-19 RNA-dependent RNA polymerase bound to suramin 分子名称: 8-(3-(3-aminobenzamido)-4-methylbenzamido)naphthalene-1,3,5-trisulfonic acid, Non-structural protein 7, Non-structural protein 8, ... 著者 Li, Z, Yin, W, Zhou, Z, Yu, X, Xu, H. 登録日 2020-09-23 公開日 2020-11-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.57 Å) 主引用文献 Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin. Nat.Struct.Mol.Biol., 28, 2021
4KBI	HCV NS5B GT1B N316Y with CMPD 4 分子名称: 5-cyclopropyl-6-{[(7-fluoro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino}-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide, HCV Polymerase 著者 Williams, S.P, Kahler, K.M, Shotwell, J.B. 登録日 2013-04-23 公開日 2013-05-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase. J.Med.Chem., 57, 2014
4KE5	HCV NS5B GT1B N316Y with GSK5852 分子名称: HCV Polymerase, [4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid 著者 Williams, S.P, Kahler, K.M, Shotwell, J.B. 登録日 2013-04-25 公開日 2013-05-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase. J.Med.Chem., 57, 2014
4Y34	Crystal Structure of Coxsackievirus B3 3D polymerase in complex with GPC-N143 分子名称: 2,2'-[(4-fluorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ... 著者 Vives-Adrian, L, Ferrer-Orta, C, Cerdaguer, N. 登録日 2015-02-10 公開日 2015-04-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015
1RDR	POLIOVIRUS 3D POLYMERASE 分子名称: CALCIUM ION, POLIOVIRUS 3D POLYMERASE 著者 Hansen, J, Long, A, Schultz, S. 登録日 1998-04-28 公開日 1998-09-16 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of the RNA-dependent RNA polymerase of poliovirus. Structure, 5, 1997
5F8L	Enterovirus 71 Polymerase Elongation Complex (C3S1 Form) 分子名称: Genome polyprotein, RNA (35-MER), RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3'), ... 著者 Shu, B, Gong, P. 登録日 2015-12-09 公開日 2016-06-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.812 Å) 主引用文献 Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation Proc.Natl.Acad.Sci.USA, 113, 2016
1MFY	SOLUTION STRUCTURE OF INFLUENZA A VIRUS C4 PROMOTER 分子名称: C4 promoter of influneza A virus 著者 Lee, M.-K, Bae, S.-H, Park, C.-J, Cheong, H.-K, Cheong, C, Choi, B.-S. 登録日 2002-08-14 公開日 2002-09-18 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 A single-nucleotide natural variation (U4 to C4) in an influenza A virus promoter exhibits a large structural change: implications for differential viral RNA synthesis by RNA-dependent RNA polymerase. Nucleic Acids Res., 31, 2003
5F8H	Enterovirus 71 Polymerase Elongation Complex (C1S1/2 Form) 分子名称: Genome polyprotein, MAGNESIUM ION, RNA (35-MER), ... 著者 Shu, B, Gong, P. 登録日 2015-12-09 公開日 2016-06-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation Proc.Natl.Acad.Sci.USA, 113, 2016

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