PDB: 435 件ウェブページステータス検索Chemie searchBIRD

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4PL9	Structure of the catalytic domain of ETR1 from Arabidopsis thaliana 分子名称: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, ... 著者 Panneerselvam, S, Mueller-Dieckmann, J. 登録日 2014-05-16 公開日 2014-12-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Model of the Cytosolic Domain of the Plant Ethylene Receptor 1 (ETR1). J.Biol.Chem., 290, 2015
2FXS	Yeast HSP82 in complex with the novel HSP90 Inhibitor Radamide 分子名称: ATP-dependent molecular chaperone HSP82, GLYCEROL, METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 著者 Immormino, R.M, Gewirth, D.T. 登録日 2006-02-06 公開日 2007-02-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design. J.Mol.Biol., 388, 2009
3C0E	Yeast Hsp82 N-terminal domain: effects of mutants 98-99 KS-AA 分子名称: ATP-dependent molecular chaperone HSP82 著者 Immormino, R.M, Gewirth, D.T. 登録日 2008-01-19 公開日 2008-07-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure of GRP94 with the Specific Mutation KS168-169AA with Bound Geldanamycin To be Published
3C11	Yeast Hsp82 N-terminal domain-Geldanamycin complex: effects of mutants 98-99 KS-AA 分子名称: ATP-dependent molecular chaperone HSP82, GELDANAMYCIN, GLYCEROL 著者 Immormino, R.M, Gewirth, D.T. 登録日 2008-01-21 公開日 2008-07-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal Structure of GRP94 with the Specific Mutation KS168-169AA with Bound Geldanamycin To be Published
3CGY	Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain in complex with radicicol 分子名称: RADICICOL, Virulence sensor histidine kinase phoQ 著者 Guarnieri, M.T, Zhang, L, Shen, J, Zhao, R. 登録日 2008-03-06 公開日 2008-05-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ. J.Mol.Biol., 379, 2008
3CGZ	Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain 分子名称: Virulence sensor histidine kinase phoQ 著者 Guarnieri, M.T, Zhang, L, Shen, J, Zhao, R. 登録日 2008-03-06 公開日 2008-05-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ. J.Mol.Biol., 379, 2008
3EHG	Crystal structure of the ATP-binding domain of DesK in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, IODIDE ION, MAGNESIUM ION, ... 著者 Trajtenberg, F, Buschiazzo, A. 登録日 2008-09-12 公開日 2009-09-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structural and enzymatic insights into the ATP binding and autophosphorylation mechanism of a sensor histidine kinase J.Biol.Chem., 285, 2010
3G7B	Staphylococcus aureus Gyrase B co-complex with METHYL ({5-[4-(4-HYDROXYPIPERIDIN-1-YL)-2-PHENYL-1,3-THIAZOL-5-YL]-1H-PYRAZOL-3-YL}METHYL)CARBAMATE inhibitor 分子名称: DNA gyrase subunit B, methyl ({5-[4-(4-hydroxypiperidin-1-yl)-2-phenyl-1,3-thiazol-5-yl]-1H-pyrazol-3-yl}methyl)carbamate 著者 Wei, Y, Charisfon, P. 登録日 2009-02-09 公開日 2010-02-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg.Med.Chem.Lett., 20, 2010
3FV5	Crystal Structure of E. coli Topoisomerase IV co-complexed with inhibitor 分子名称: 1-(4-acetyl-6-pyridin-3-yl-1H-benzimidazol-2-yl)-3-ethylurea, DNA topoisomerase 4 subunit B 著者 Wei, Y, Charifson, P, LeTiran, A. 登録日 2009-01-15 公開日 2010-01-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Design and syntheses of novel C7-derived-aminobenzimidazole ureas: bacterial gyrase/topoisomerase IV inhibitors with potent Gram-positve antibacterial activity To be Published
3G7E	Crystal structure of E. coli Gyrase B co-complexed with PROP-2-YN-1-YL {[5-(4-PIPERIDIN-1-YL-2-PYRIDIN-3-YL-1,3-THIAZOL-5-YL)-1H-PYRAZOL-3-YL]METHYL}CARBAMATE inhibitor 分子名称: DNA gyrase subunit B, prop-2-yn-1-yl {[5-(4-piperidin-1-yl-2-pyridin-3-yl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methyl}carbamate 著者 Wei, Y, Charifson, P. 登録日 2009-02-09 公開日 2010-02-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg.Med.Chem.Lett., 20, 2010
3G75	Crystal structure of Staphylococcus aureus Gyrase B co-complexed with 4-METHYL-5-[3-(METHYLSULFANYL)-1H-PYRAZOL-5-YL]-2-THIOPHEN-2-YL-1,3-THIAZOLE inhibitor 分子名称: 4-methyl-5-[3-(methylsulfanyl)-1H-pyrazol-5-yl]-2-thiophen-2-yl-1,3-thiazole, DNA gyrase subunit B 著者 Wei, Y, Charifson, P. 登録日 2009-02-09 公開日 2010-02-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg.Med.Chem.Lett., 20, 2010
3H80	Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LmjF33.0312:M1-K213 分子名称: 1,2-ETHANEDIOL, Heat shock protein 83-1, MAGNESIUM ION, ... 著者 Wernimont, A.K, Tempel, W, Lin, Y.H, Hutchinson, A, Mackenzie, F, Fairlamb, A, Kozieradzki, I, Cossar, D, Zhao, Y, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC) 登録日 2009-04-28 公開日 2009-05-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LmjF33.0312:M1-K213 To be Published
2VW5	Structure Of The Hsp90 Inhibitor 7-O-carbamoylpremacbecin Bound To The N- Terminus Of Yeast Hsp90 分子名称: (4E,8S,9R,10E,12S,13R,14S,16R)-13,20-dihydroxy-14-methoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(22),4,10,18,20-pentaen-9-yl carbamate, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, SULFATE ION 著者 Roe, S.M, Prodromou, C, Pearl, L.H. 登録日 2008-06-16 公開日 2008-09-02 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors. J.Med.Chem., 51, 2008
2VWC	STRUCTURE OF THE HSP90 INHIBITOR MACBECIN BOUND TO THE N-TERMINUS OF YEAST HSP90. 分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GLYCEROL, MACBECIN 著者 Roe, S.M, Prodromou, C, Pearl, L.H. 登録日 2008-06-20 公開日 2008-07-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Molecular Characterisation of Macbecin as an Hsp90 Inhibitor J.Med.Chem., 51, 2008
2WEQ	Yeast Hsp90 N-terminal domain LI-IV mutant with Geldanamycin 分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GELDANAMYCIN, GLYCEROL 著者 Roe, S.M, Prodromou, C, Pearl, L.H. 登録日 2009-04-01 公開日 2009-04-14 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90 Acs Chem.Biol., 4, 2009
2WEP	Yeast Hsp90 N-terminal domain LI-IV mutant with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 著者 Roe, S.M, Prodromou, C, Pearl, L.H. 登録日 2009-04-01 公開日 2009-04-14 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90. Acs Chem.Biol., 4, 2009
2XD6	Hsp90 complexed with a resorcylic acid macrolactone. 分子名称: (5Z)-13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-3,4,7,8,9,10,11,12-OCTAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-6-CARBALDEHYDE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GLYCEROL 著者 Roe, S.M, Prodromou, C, Pearl, L.H, Moody, C.J. 登録日 2010-04-29 公開日 2010-08-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Inhibition of Hsp90 with Resorcylic Acid Macrolactones. Synthesis and Binding Studies. Chemistry, 16, 2010
2XX4	Macrolactone Inhibitor bound to HSP90 N-term 分子名称: (E)-ETHYL 13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-1,2,3,4,7,8,9,10,11,12-DECAHYDROBENZO[C][1]AZACYCLOTETRADECINE-10-CARBOXYLATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 著者 Moody, C.J, Prodromou, C, Pearl, L.H, Roe, S.M. 登録日 2010-11-08 公開日 2011-11-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.199 Å) 主引用文献 Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies. Acs Chem.Biol., 6, 2011
2XX5	Macrolactone Inhibitor bound to HSP90 N-term 分子名称: (5E,10R)-N-BENZYL-13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-1,2,3,4,7,8,9,10,11,12-DECAHYDRO-2-BENZAZACYCLOTETRADECINE-10-CARBOXAMIDE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GLYCEROL 著者 Moody, C.J, Prodromou, C, Pearl, L.H, Roe, S.M. 登録日 2010-11-08 公開日 2011-11-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies. Acs Chem.Biol., 6, 2011
2XX2	Macrolactone Inhibitor bound to HSP90 N-term 分子名称: (5E)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-2-BENZAZACYCLOTETRADECINE-1,11(2H,12H)-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GLYCEROL 著者 Moody, C.J, Prodromou, C, Pearl, L.H, Roe, S.M. 登録日 2010-11-08 公開日 2011-11-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies. Acs Chem.Biol., 6, 2011
2YGE	E88G-N92L Mutant of N-Term HSP90 complexed with Geldanamycin 分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GELDANAMYCIN, GLYCEROL 著者 Roe, M, Prodromou, C, Pearl, L.H. 登録日 2011-04-14 公開日 2011-11-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.956 Å) 主引用文献 Features of the Streptomyces Hygroscopicus Htpg Reveal How Partial Geldanamycin Resistance Can Arise by Mutation to the ATP Binding Pocket of a Eukaryotic Hsp90. Faseb J., 25, 2011
2YGA	E88G-N92L Mutant of N-Term HSP90 complexed with Geldanamycin 分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GELDANAMYCIN 著者 Roe, S.M, Prodromou, C, Pearl, L.H. 登録日 2011-04-12 公開日 2011-11-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Features of the Streptomyces Hygroscopicus Htpg Reveal How Partial Geldanamycin Resistance Can Arise with Mutation to the ATP Binding Pocket of a Eukaryotic Hsp90. Faseb J., 25, 2011
2YGF	L89V, L93I and V136M Mutant of N-Term HSP90 complexed with Geldanamycin 分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GELDANAMYCIN, GLYCEROL 著者 Roe, M, Prodromou, C, Pearl, L.H. 登録日 2011-04-14 公開日 2011-11-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Features of the Streptomyces Hygroscopicus Htpg Reveal How Partial Geldanamycin Resistance Can Arise by Mutation to the ATP Binding Pocket of a Eukaryotic Hsp90. Faseb J., 25, 2011
3A0Y	Catalytic domain of histidine kinase ThkA (TM1359) (nucleotide free form 3: 1,2-propanediol, orthorombic) 分子名称: Sensor protein 著者 Yamada, S, Sugimoto, H, Kobayashi, M, Ohno, A, Nakamura, H, Shiro, Y. 登録日 2009-03-25 公開日 2009-10-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Structure of PAS-linked histidine kinase and the response regulator complex Structure, 17, 2009
3A0W	Catalytic domain of histidine kinase ThkA (TM1359) for MAD phasing (nucleotide free form 2, orthorombic) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(ETHYLMERCURI-THIO)-BENZOIC ACID, ETHYL MERCURY ION, ... 著者 Yamada, S, Sugimoto, H, Kobayashi, M, Ohno, A, Nakamura, H, Shiro, Y. 登録日 2009-03-24 公開日 2009-10-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Structure of PAS-linked histidine kinase and the response regulator complex Structure, 17, 2009

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