6CJP

Candida albicans Hsp90 nucleotide binding domain in complex with radicicol

Summary for 6CJP

• Entry DOI: 10.2210/pdb6cjp/pdb
• Related: 6CJI 6CJJ 6CJL
• Descriptor: Heat shock protein 90 homolog, (1aR,2Z,4E,6E,14R,15aR)-9,11-dihydroxy-6-{[(4-methoxyphenyl)methoxy]imino}-14-methyl-1a,6,7,14,15,15a-hexahydro-12H-oxireno[e][2]benzoxacyclotetradecin-12-one (3 entities in total)
• Functional Keywords: hsp90. atpase, chaperone
• Biological source: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
• Total number of polymer chains: 2
• Total formula weight: 53348.27

Authors

Nation, C.,Pizarro, J.C. (deposition date: 2018-02-26, release date: 2019-01-30, Last modification date: 2023-10-04)

• Primary citation: Whitesell, L.,Robbins, N.,Huang, D.S.,McLellan, C.A.,Shekhar-Guturja, T.,LeBlanc, E.V.,Nation, C.S.,Hui, R.,Hutchinson, A.,Collins, C.,Chatterjee, S.,Trilles, R.,Xie, J.L.,Krysan, D.J.,Lindquist, S.,Porco Jr., J.A.,Tatu, U.,Brown, L.E.,Pizarro, J.,Cowen, L.E.; Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.; Nat Commun, 10:402-402, 2019; PubMed: 30679438; DOI: 10.1038/s41467-018-08248-w

Experimental method

X-RAY DIFFRACTION (2.6 Å)