PDB: 198 件ウェブページステータス検索Chemie searchBIRD

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6PWY	Structure of C. elegans ZK177.8, SAMHD1 ortholog 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Lim, C.S, Maehigashi, T, Wade, L.R, Bowen, N, Knecht, K, Xiong, Y, Kim, B. 登録日 2019-07-24 公開日 2020-07-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 ZK177.8 of Caenorhabditis elegans: Aicardi-Goutieres Syndrome SAMHD1 Ortholog To Be Published
6TX0	Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dAMPNPP and Mg 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... 著者 Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A. 登録日 2020-01-13 公開日 2020-06-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun, 11, 2020
6TXA	Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dGMPNPP and Mg 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... 著者 Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A, Kelly, G, Taylor, I.A. 登録日 2020-01-13 公開日 2020-06-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.853 Å) 主引用文献 Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun, 11, 2020
6TXC	Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, dATP, dCMPNPP and Mg 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... 著者 Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A, Kelly, G, Taylor, I.A. 登録日 2020-01-14 公開日 2020-06-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun, 11, 2020
6TXE	Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, dATP, dTMPNPP and Mg 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... 著者 Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A. 登録日 2020-01-14 公開日 2020-06-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun, 11, 2020
6TXF	Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dAMPNPP and Mn 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... 著者 Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A. 登録日 2020-01-14 公開日 2020-06-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun, 11, 2020
6U6X	Human SAMHD1 bound to deoxyribo(C*G*C*C*T)-oligonucleotide 分子名称: DNA SC-GS-SC-SC-DT, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ZINC ION 著者 Taylor, A.B, Bhattacharya, A, Wang, Z, Ivanov, D.N. 登録日 2019-08-30 公開日 2020-09-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification. Nat Commun, 12, 2021
6U6Y	Human SAMHD1 bound to ribo(CGCCU)-oligonucleotide 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, RNA CGCCU, ... 著者 Taylor, A.B, Bhattacharya, A, Wang, Z, Ivanov, D.N. 登録日 2019-08-30 公開日 2020-09-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification. Nat Commun, 12, 2021
6U6Z	Human SAMHD1 bound to deoxyribo(TG*TTCA)-oligonucleotide 分子名称: DNA polymer TG(PST)TCA, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ZINC ION 著者 Taylor, A.B, Yu, C.H, Ivanov, D.N. 登録日 2019-08-30 公開日 2020-09-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification. Nat Commun, 12, 2021
6XN3	Structure of the Lactococcus lactis Csm CTR_4:3 CRISPR-Cas Complex 分子名称: CRISPR-associated protein Cas10, CRISPR-associated protein Csm2, CRISPR-associated protein Csm3, ... 著者 Rai, J, Sridhara, S, Li, H. 登録日 2020-07-02 公開日 2022-01-12 最終更新日 2022-04-13 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex. Commun Biol, 5, 2022
6XN4	Structure of the Lactococcus lactis Csm CTR_3:2 CRISPR-Cas Complex 分子名称: CRISPR-associated protein Cas10, CRISPR-associated protein Csm2, CRISPR-associated protein Csm3, ... 著者 Rai, J, Sridhara, S, Li, H. 登録日 2020-07-02 公開日 2022-01-12 最終更新日 2022-04-13 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex. Commun Biol, 5, 2022
6XN5	Structure of the Lactococcus lactis Csm Apo- CRISPR-Cas Complex 分子名称: CRISPR-associated protein Cas10, CRISPR-associated protein Csm3, CRISPR-associated protein Csm4, ... 著者 Rai, J, Sridhara, S, Li, H. 登録日 2020-07-02 公開日 2022-01-12 最終更新日 2022-04-13 実験手法 ELECTRON MICROSCOPY (2.97 Å) 主引用文献 Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex. Commun Biol, 5, 2022
6XN7	Structure of the Lactococcus lactis Csm NTR CRISPR-Cas Complex 分子名称: CRISPR-associated protein Cas10, CRISPR-associated protein Csm2, CRISPR-associated protein Csm3, ... 著者 Rai, J, Sridhara, S, Li, H. 登録日 2020-07-02 公開日 2022-01-12 最終更新日 2022-04-13 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex. Commun Biol, 5, 2022
6XU1	Crystal structure of tetrameric human H215A-SAMHD1 (residues 109-626) with GTP, dAMPNPP and Mg 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... 著者 Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A. 登録日 2020-01-17 公開日 2020-06-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun, 11, 2020
6YOM	Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dATP, dCMPNPP, Mn and Mg 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... 著者 Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A. 登録日 2020-04-14 公開日 2020-06-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun, 11, 2020
6YXA	Structure of the bifunctional Rel enzyme from B. subtilis 分子名称: GTP pyrophosphokinase, MANGANESE (II) ION 著者 Pausch, P, Bange, G. 登録日 2020-04-30 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.95 Å) 主引用文献 Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel. Cell Rep, 32, 2020
7A5Y	Crystal structure of tetrameric human H215A-SAMHD1 (residues 109-626) with Rp-dGTP-alphaS (T8T) and Mg 分子名称: 2'-deoxyguanosine-5'-O-(1-thiotriphosphate), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... 著者 Morris, E.R, Kunzelmann, S, Caswell, S.J, Purkiss, A, Taylor, I.A. 登録日 2020-08-24 公開日 2021-05-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R p - and S p -dNTP alpha S Diastereomers. Biochemistry, 60, 2021
7LTT	SAMHD1(113-626) H206R D207N R366C 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, MAGNESIUM ION 著者 Temple, J.T, Bowen, N.E. 登録日 2021-02-20 公開日 2021-11-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins. J.Biol.Chem., 297, 2021
7LU5	SAMHD1(113-626) H206R D207N R366H 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 著者 Temple, J.T, Bowen, N.E. 登録日 2021-02-20 公開日 2021-11-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.57 Å) 主引用文献 Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins. J.Biol.Chem., 297, 2021
7S2Y	SAMHD1 HD domain bound to CNDAC 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 4-amino-1-{2-cyano-2-deoxy-5-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}pyrimidin-2(1H)-one, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... 著者 Digianantonio, K.M, Xiong, Y. 登録日 2021-09-04 公開日 2021-10-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells. J Exp Clin Cancer Res, 40, 2021
7TU0	Structure of the L. blandensis dGTPase bound to Mn 分子名称: MANGANESE (II) ION, SULFATE ION, dGTP triphosphohydrolase 著者 Sikkema, A.P, Klemm, B.P, Horng, J.C, Hall, T.M.T. 登録日 2022-02-02 公開日 2022-06-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. J.Biol.Chem., 298, 2022
7TU1	Structure of the L. blandensis dGTPase R37A mutant 分子名称: 1,2-ETHANEDIOL, SULFATE ION, dGTP triphosphohydrolase 著者 Sikkema, A.P, Klemm, B.P, Horng, J.C, Hall, T.M.T. 登録日 2022-02-02 公開日 2022-06-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. J.Biol.Chem., 298, 2022
7TU2	Structure of the L. blandensis dGTPase R37A mutant bound to Mn 分子名称: MANGANESE (II) ION, SULFATE ION, dGTP triphosphohydrolase 著者 Sikkema, A.P, Klemm, B.P, Horng, J.C, Hall, T.M.T. 登録日 2022-02-02 公開日 2022-06-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. J.Biol.Chem., 298, 2022
7TU3	Structure of the L. blandensis dGTPase del55-58 mutant 分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, SULFATE ION, ... 著者 Sikkema, A.P, Klemm, B.P, Horng, J.C, Hall, T.M.T. 登録日 2022-02-02 公開日 2022-06-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. J.Biol.Chem., 298, 2022
7TU4	Structure of the L. blandensis dGTPase del55-58 mutant bound to Mn 分子名称: 1,2-ETHANEDIOL, MANGANESE (II) ION, SULFATE ION, ... 著者 Sikkema, A.P, Klemm, B.P, Horng, J.C, Hall, T.M.T. 登録日 2022-02-02 公開日 2022-06-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. J.Biol.Chem., 298, 2022

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