6TXC

Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, dATP, dCMPNPP and Mg

Summary for 6TXC

Entry DOI	10.2210/pdb6txc/pdb
Related	6TX0 6TXA
Descriptor	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, MAGNESIUM ION, ... (7 entities in total)
Functional Keywords	triphosphohydrolase, metallo-enzyme, binuclear, hd, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	16
Total formula weight	989808.39
Authors	Morris, E.R.,Kunzelmann, S.,Caswell, S.J.,Arnold, L.H.,Purkiss, A.,Kelly, G.,Taylor, I.A. (deposition date: 2020-01-14, release date: 2020-06-24, Last modification date: 2024-01-24)
Primary citation	Morris, E.R.,Caswell, S.J.,Kunzelmann, S.,Arnold, L.H.,Purkiss, A.G.,Kelly, G.,Taylor, I.A. Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun, 11:3165-3165, 2020 Cited by PubMed: 32576829 DOI: 10.1038/s41467-020-16983-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.84 Å)

Structure validation