6TXC
Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, dATP, dCMPNPP and Mg
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 520 | 60208.8 | 16 | UniProt (Q9Y3Z3) Pfam (PF01966) | Homo sapiens (Human) | dNTPase,Dendritic cell-derived IFNG-induced protein,DCIP,Monocyte protein 5,MOP-5,SAM domain and HD domain-containing protein 1,hSAMHD1 |
| 2 | AD, CB, EC, HA, ID... (M, F, J, C, N...) | FE (III) ION | non-polymer | 55.8 | 16 | Chemie (FE) | |||
| 3 | AA, BA, BD, CD, DB... (B, M, F, J, C...) | MAGNESIUM ION | non-polymer | 24.3 | 42 | Chemie (MG) | |||
| 4 | AC, AE, CA, ED, FB... (I, P, B, M, F...) | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine | non-polymer | 466.2 | 16 | Chemie (0KX) | |||
| 5 | AB, BC, DA, FD, GB... (E, I, B, M, F...) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 16 | Chemie (GTP) | |||
| 6 | CC, EA, GD, JC, NA... (I, B, M, J, C...) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 7 | BB, DC, FA, GA, HB... (E, I, B, C, F...) | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE | non-polymer | 491.2 | 16 | Chemie (DTP) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P: 109 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Gly 107 | - | expression tag |
| Ser 108 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 963340.9 | |
| Non-Polymers* | Number of molecules | 115 |
| Total formula weight | 26467.4 | |
| All* | Total formula weight | 989808.4 |
