8A65
| Small molecule stabilizer (compound 3) for FOXO1 and 14-3-3 | 分子名称: | (3~{S})-1-[2-azanyl-3,5-bis(chloranyl)phenyl]carbonyl-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-3-carboxamide, 14-3-3 protein sigma, Forkhead box protein O1, ... | 著者 | Kenanova, D.N, Visser, E.J, Virta, J, Sijbesma, E, Centorrino, F, Zhong, M, Vickery, H, Neitz, J, Brunsveld, L, Ottmann, C, Arkin, M.R. | 登録日 | 2022-06-16 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. Acs Cent.Sci., 9, 2023
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8A62
| Small molecule stabilizer (compound 2) for FOXO1 and 14-3-3 | 分子名称: | (3~{S})-1-[3,5-bis(chloranyl)-4-oxidanyl-phenyl]carbonyl-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-3-carboxamide, 14-3-3 protein sigma, Forkhead box protein O1, ... | 著者 | Kenanova, D.N, Visser, E.J, Virta, J, Sijbesma, E, Centorrino, F, Zhong, M, Vickery, H, Neitz, J, Brunsveld, L, Ottmann, C, Arkin, M.R. | 登録日 | 2022-06-16 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. Acs Cent.Sci., 9, 2023
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8A68
| Small molecule stabilizer (compound 5) for C-RAF(pS259) and 14-3-3 | 分子名称: | 14-3-3 protein sigma, MAGNESIUM ION, RAF proto-oncogene serine/threonine-protein kinase, ... | 著者 | Kenanova, D.N, Visser, E.J, Virta, J, Sijbesma, E, Centorrino, F, Zhong, M, Vickery, H, Neitz, J, Brunsveld, L, Ottmann, C, Arkin, M.R. | 登録日 | 2022-06-16 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. Acs Cent.Sci., 9, 2023
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7ZMU
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7ZMW
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7ZIT
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7XBQ
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7QIP
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7QIK
| SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma | 分子名称: | 14-3-3 protein sigma, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, ... | 著者 | Sluchanko, N.N, Tugaeva, K.V, Smith, J.L.R, Antson, A.A. | 登録日 | 2021-12-15 | 公開日 | 2021-12-29 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma To Be Published
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7QI1
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7Q16
| Human 14-3-3 zeta fused to the BAD peptide including phosphoserine-74 | 分子名称: | 14-3-3 protein zeta/delta,Bcl2-associated agonist of cell death | 著者 | Sluchanko, N.N, Tugaeva, K.V, Gushchin, I, Remeeva, A, Kovalev, K, Cooley, R.B. | 登録日 | 2021-10-18 | 公開日 | 2021-11-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.356 Å) | 主引用文献 | Crystal structure of human 14-3-3 zeta complexed with the noncanonical phosphopeptide from proapoptotic BAD. Biochem.Biophys.Res.Commun., 583, 2021
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7PWZ
| Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptoralpha phosphopeptide, stabilised by Pyrrolidone1 derivative 228 | 分子名称: | 14-3-3 protein sigma, 2-oxidanyl-5-[(2~{R})-4-oxidanyl-5-oxidanylidene-2-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-3-(phenylcarbonyl)-2~{H}-pyrrol-1-yl]benzoic acid, C-terminus of Estrogen receptor alpha, ... | 著者 | Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C. | 登録日 | 2021-10-07 | 公開日 | 2022-12-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65, 2022
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7PWT
| Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptor alpha phosphopeptide, stabilised by pyrrolidone derivative 228 | 分子名称: | (2~{R})-1-(2-hydroxyphenyl)-2-(4-nitrophenyl)-4-oxidanyl-3-(phenylcarbonyl)-2~{H}-pyrrol-5-one, 14-3-3 protein sigma, C-terminus of Estrogen receptor alpha, ... | 著者 | Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C. | 登録日 | 2021-10-07 | 公開日 | 2022-12-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.312 Å) | 主引用文献 | Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65, 2022
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7V9B
| Crystal Structure of 14-3-3 epsilon with FOXO3a peptide | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[3,6-bis(dimethylamino)xanthen-9-yl]-5-methanoyl-benzoate, ARG-ARG-ARG-ALA-VAL-SEP-MET-ASP-ASN-SER-ASN, ... | 著者 | Mathivanan, S, Kamariah, N. | 登録日 | 2021-08-24 | 公開日 | 2022-08-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure of a 14-3-3 epsilon :FOXO3a pS253 Phosphopeptide Complex Reveals 14-3-3 Isoform-Specific Binding of Forkhead Box Class O Transcription Factor (FOXO) Phosphoproteins. Acs Omega, 7, 2022
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7ORT
| Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ176 | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ... | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | 登録日 | 2021-06-06 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7ORS
| Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ147 | 分子名称: | (4~{S})-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]oxepane-4-carboxamide, 14-3-3 protein sigma, CHLORIDE ION, ... | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | 登録日 | 2021-06-06 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7ORG
| Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ162 | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ... | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | 登録日 | 2021-06-05 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7ORH
| Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ178 | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ... | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | 登録日 | 2021-06-05 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7OR7
| Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ178 | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | 登録日 | 2021-06-04 | 公開日 | 2022-07-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7OR5
| Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ162 | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, Neurogenic locus notch homolog protein 4, ... | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | 登録日 | 2021-06-04 | 公開日 | 2022-07-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7OQS
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7OQU
| Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ180 | 分子名称: | (2~{S},3~{S})-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-3-methyl-2,3-dihydro-1-benzofuran-2-carboxamide, 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), ... | 著者 | Centorrino, F, Ottmann, C. | 登録日 | 2021-06-04 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7OQW
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7OR3
| Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ136 | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | 登録日 | 2021-06-04 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7OR8
| Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ136 | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | 登録日 | 2021-06-04 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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