PDB: 663 件ウェブページステータス検索Chemie searchBIRD

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3G3H	Crystal structure of the GluR6 ligand binding domain dimer K665R I749L Q753K mutant with glutamate and NaCl at 1.5 Angstrom resolution 分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... 著者 Chaudhry, C, Mayer, M.L. 登録日 2009-02-02 公開日 2009-06-02 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3G3K	Crystal structure of the GluR6 ligand binding domain dimer I442H K494E K665R I749L Q753K E757Q mutant with glutamate and NaCl at 1.24 Angstrom resolution 分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... 著者 Chaudhry, C, Mayer, M.L. 登録日 2009-02-02 公開日 2009-06-02 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3G3J	Crystal structure of the GluR6 ligand binding domain dimer I442H K494E K665R I749L Q753K mutant with glutamate and NaCl at 1.32 Angstrom resolution 分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... 著者 Chaudhry, C, Mayer, M.L. 登録日 2009-02-02 公開日 2009-06-02 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.321 Å) 主引用文献 Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3G3G	Crystal structure of the GluR6 ligand binding domain dimer K665R mutant with glutamate and NaCl at 1.3 Angstrom resolution 分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... 著者 Chaudhry, C, Mayer, M.L. 登録日 2009-02-02 公開日 2009-06-02 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.303 Å) 主引用文献 Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3G3I	Crystal structure of the GluR6 ligand binding domain dimer I442H K494E I749L Q753K mutant with glutamate and NaCl at 1.37 Angstrom resolution 分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... 著者 Chaudhry, C, Mayer, M.L. 登録日 2009-02-02 公開日 2009-06-02 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.371 Å) 主引用文献 Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3GBA	X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with dysiherbaine at 1.35A resolution 分子名称: (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, CHLORIDE ION, GLYCEROL, ... 著者 Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S. 登録日 2009-02-19 公開日 2009-03-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine J.Biol.Chem., 284, 2009
3GBB	X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution 分子名称: (2R,3aR,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid, Glutamate receptor, ionotropic kainate 1 著者 Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S. 登録日 2009-02-19 公開日 2009-03-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine J.Biol.Chem., 284, 2009
3H06	Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 分子名称: 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid, Glutamate receptor 2 著者 Ahmed, A.H, Oswald, R.E. 登録日 2009-04-08 公開日 2009-05-05 最終更新日 2017-08-23 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain. Biochemistry, 48, 2009
3H03	Crystal structure of the binding domain of the AMPA subunit GluR2 bound to UBP277 分子名称: 3-[3-(2-carboxyethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-L-alanine, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2009-04-08 公開日 2009-05-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain. Biochemistry, 48, 2009
3H6W	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution 分子名称: (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... 著者 Hald, H, Gajhede, M, Kastrup, J.S. 登録日 2009-04-24 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
3H6U	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS1493 at 1.85 A resolution 分子名称: (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, CITRATE ANION, GLUTAMIC ACID, ... 著者 Hald, H, Gajhede, M, Kastrup, J.S. 登録日 2009-04-24 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
3H6T	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution 分子名称: ACETATE ION, CACODYLATE ION, CYCLOTHIAZIDE, ... 著者 Hald, H, Gajhede, M, Kastrup, J.S. 登録日 2009-04-24 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
3H6V	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5206 at 2.10 A resolution 分子名称: (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... 著者 Hald, H, Gajhede, M, Kastrup, J.S. 登録日 2009-04-24 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
2WKY	Crystal structure of the ligand-binding core of GluR5 in complex with the agonist 4-AHCP 分子名称: 3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... 著者 Naur, P, Gajhede, M, Kastrup, J.S. 登録日 2009-06-18 公開日 2009-07-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The Glutamate Receptor Glur5 Agonist (S)-2-Amino-3-(3-Hydroxy-7,8-Dihydro-6H-Cyclohepta[D]Isoxazol-4-Yl)Propionic Acid and the 8-Methyl Analogue: Synthesis, Molecular Pharmacology, and Biostructural Characterization J.Med.Chem., 52, 2009
3IJO	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide 分子名称: (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... 著者 Ptak, C.P, Ahmed, A.H, Oswald, R.E. 登録日 2009-08-04 公開日 2009-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.003 Å) 主引用文献 Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3IK6	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, chlorothiazide 分子名称: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... 著者 Ptak, C.P, Ahmed, A.H, Oswald, R.E. 登録日 2009-08-05 公開日 2009-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3IJX	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydrochlorothiazide 分子名称: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... 著者 Ptak, C.P, Ahmed, A.H, Oswald, R.E. 登録日 2009-08-05 公開日 2009-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.881 Å) 主引用文献 Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3IL1	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21 分子名称: (3S)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... 著者 Ahmed, A.H, Ptak, C.P, Oswald, R.E. 登録日 2009-08-06 公開日 2009-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.998 Å) 主引用文献 Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3ILT	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, trichlormethiazide 分子名称: 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE, GLUTAMIC ACID, Glutamate receptor 2, ... 著者 Ahmed, A.H, Ptak, C.P, Oswald, R.E. 登録日 2009-08-07 公開日 2009-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.107 Å) 主引用文献 Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3ILU	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydroflumethiazide 分子名称: 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... 著者 Ahmed, A.H, Ptak, C.P, Oswald, R.E. 登録日 2009-08-07 公開日 2009-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.003 Å) 主引用文献 Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3KEI	Crystal Structure of the GluA4 Ligand-Binding domain L651V mutant in complex with glutamate 分子名称: GLUTAMIC ACID, Glutamate receptor 4 著者 Gill, A, Madden, D.R. 登録日 2009-10-26 公開日 2010-02-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors. J.Neurosci., 30, 2010
3KFM	Crystal Structure of the GluA4 Ligand-Binding domain L651V mutant in complex with kainate 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 4 著者 Gill, A, Madden, D.R. 登録日 2009-10-27 公開日 2010-02-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors. J.Neurosci., 30, 2010
3KG2	AMPA subtype ionotropic glutamate receptor in complex with competitive antagonist ZK 200775 分子名称: Glutamate receptor 2, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Sobolevsky, A.I, Rosconi, M.P, Gouaux, E. 登録日 2009-10-28 公開日 2009-12-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature, 462, 2009
3KGC	Isolated ligand binding domain dimer of GluA2 ionotropic glutamate receptor in complex with glutamate, LY 404187 and ZK 200775 分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-[(2S)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide, ... 著者 Sobolevsky, A.I, Rosconi, M.P, Gouaux, E. 登録日 2009-10-28 公開日 2009-12-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor Nature, 462, 2009
3LSF	Piracetam bound to the ligand binding domain of GluA2 分子名称: 2-(2-oxopyrrolidin-1-yl)acetamide, GLUTAMIC ACID, Glutamate receptor 2, ... 著者 Ahmed, A.H, Ptak, C.P, Oswald, R.E. 登録日 2010-02-12 公開日 2010-03-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.851 Å) 主引用文献 Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors. J.Med.Chem., 53, 2010

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