3UU7
 
 | | Crystal structure of hERa-LBD (Y537S) in complex with bisphenol-A | | 分子名称: | 4,4'-PROPANE-2,2-DIYLDIPHENOL, Estrogen receptor, Nuclear receptor coactivator 1 | | 著者 | Delfosse, V, Grimaldi, M, Bourguet, W. | | 登録日 | 2011-11-28 | | 公開日 | 2012-08-22 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.196 Å) | | 主引用文献 | Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3UUC
 | | Crystal structure of hERa-LBD (wt) in complex with bisphenol-C | | 分子名称: | 4,4'-(2,2-dichloroethene-1,1-diyl)diphenol, Estrogen receptor | | 著者 | Delfosse, V, Grimaldi, M, Bourguet, W. | | 登録日 | 2011-11-28 | | 公開日 | 2012-08-22 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4XAO
 | | Crystal structure of the hPXR-LBD obtained in presence of the pesticide trans-nonachlor | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ISOPROPYL ALCOHOL, Nuclear receptor subfamily 1 group I member 2 | | 著者 | Delfosse, V, Huet, T, Bourguet, W. | | 登録日 | 2014-12-15 | | 公開日 | 2015-09-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.
Nat Commun, 6, 2015
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4X1F
 | | Crystal structure of the hPXR-LBD in complex with the synthetic estrogen 17alpha-ethinylestradiol | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Ethinyl estradiol, Nuclear receptor subfamily 1 group I member 2 | | 著者 | Delfosse, V, Huet, T, Bourguet, W. | | 登録日 | 2014-11-24 | | 公開日 | 2015-09-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.
Nat Commun, 6, 2015
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8R81
 | | Crystal structure of the hPXR-LBD in complex with compound JMV6845 | | 分子名称: | 2,4,6-trimethyl-~{N}-[1-(phenylmethyl)benzimidazol-5-yl]benzenesulfonamide, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Delfosse, V, Huet, T, Bourguet, W. | | 登録日 | 2023-11-27 | | 公開日 | 2025-06-11 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Crystal structure of the hPXR-LBD in complex with compound JMV6845
To Be Published
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8R82
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7AXJ
 | | Crystal structure of the hPXR-LBD in complex with estradiol and clotrimazole | | 分子名称: | 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ESTRADIOL, Nuclear receptor subfamily 1 group I member 2 | | 著者 | Delfosse, V, Granell, M, Blanc, P, Bourguet, W. | | 登録日 | 2020-11-09 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7AXL
 | | Crystal structure of the hPXR-LBD in complex with estradiol and heptachlor endo-epoxide | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ESTRADIOL, Nuclear receptor subfamily 1 group I member 2, ... | | 著者 | Delfosse, V, Granell, M, Blanc, P, Bourguet, W. | | 登録日 | 2020-11-09 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7AX8
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7AXA
 | | Crystal structure of the hPXR-LBD in complex with clotrimazole | | 分子名称: | 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, Nuclear receptor subfamily 1 group I member 2 | | 著者 | Delfosse, V, Granell, M, Blanc, P, Bourguet, W. | | 登録日 | 2020-11-09 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7AXG
 | | Crystal structure of the hPXR-LBD in complex with tributyltin | | 分子名称: | Nuclear receptor subfamily 1 group I member 2, tributylstannanyl | | 著者 | Delfosse, V, Huet, T, Blanc, P, Bourguet, W. | | 登録日 | 2020-11-09 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures.
Proc.Natl.Acad.Sci.USA, 118, 2021
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1K6O
 | | Crystal Structure of a Ternary SAP-1/SRF/c-fos SRE DNA Complex | | 分子名称: | 5'-D(*CP*AP*CP*AP*GP*GP*AP*TP*GP*TP*CP*CP*AP*TP*AP*TP*TP*AP*GP*GP*AP*CP*A)-3', 5'-D(*TP*GP*TP*CP*CP*TP*AP*AP*TP*AP*TP*GP*GP*AP*CP*AP*TP*CP*CP*TP*GP*TP*G)-3', ETS-domain protein ELK-4, ... | | 著者 | Mo, Y, Ho, W, Johnston, K, Marmorstein, R. | | 登録日 | 2001-10-16 | | 公開日 | 2002-01-17 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | | 主引用文献 | Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex.
J.Mol.Biol., 314, 2001
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1BC8
 | | STRUCTURES OF SAP-1 BOUND TO DNA SEQUENCES FROM THE E74 AND C-FOS PROMOTERS PROVIDE INSIGHTS INTO HOW ETS PROTEINS DISCRIMINATE BETWEEN RELATED DNA TARGETS | | 分子名称: | DNA (5'-D(*AP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*GP*GP*AP*AP*GP*T)-3'), PROTEIN (SAP-1 ETS DOMAIN), ... | | 著者 | Mo, Y, Vaessen, B, Johnston, K, Marmorstein, R. | | 登録日 | 1998-05-05 | | 公開日 | 1998-12-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins.
Mol.Cell, 2, 1998
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5FV8
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3QUN
 | | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with MgATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, FomA protein, GLYCEROL, ... | | 著者 | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | | 登録日 | 2011-02-24 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA.
Biochemistry, 50, 2011
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3QUR
 | | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with MgADP and fosfomycin monophosphate | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, FomA protein, MAGNESIUM ION, ... | | 著者 | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | | 登録日 | 2011-02-24 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA.
Biochemistry, 50, 2011
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3QVH
 | | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, FomA protein | | 著者 | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | | 登録日 | 2011-02-25 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA.
Biochemistry, 50, 2011
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3QVF
 | | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with MgADP and fosfomycin vanadate | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, FomA protein, MAGNESIUM ION, ... | | 著者 | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | | 登録日 | 2011-02-25 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA.
Biochemistry, 50, 2011
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4KP7
 | | Structure of Plasmodium IspC in complex with a beta-thia-isostere derivative of Fosmidomycin | | 分子名称: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, MANGANESE (III) ION, ... | | 著者 | Kunfermann, A, Bacher, A, Groll, M. | | 登録日 | 2013-05-13 | | 公開日 | 2013-10-02 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | IspC as Target for Antiinfective Drug Discovery: Synthesis, Enantiomeric Separation, and Structural Biology of Fosmidomycin Thia Isosters.
J.Med.Chem., 56, 2013
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2P7L
 | | Crystal structure of monoclinic form of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes at pH 5.75 | | 分子名称: | GLYCEROL, Glyoxalase family protein | | 著者 | Fillgrove, K.L, Pakhomova, S, Schaab, M, Newcomer, M.E, Armstrong, R.N. | | 登録日 | 2007-03-20 | | 公開日 | 2007-07-17 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure and Mechanism of the Genomically Encoded Fosfomycin Resistance Protein, FosX, from Listeria monocytogenes.
Biochemistry, 46, 2007
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2P7P
 | | Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and sulfate ion | | 分子名称: | Glyoxalase family protein, MANGANESE (II) ION, SULFATE ION | | 著者 | Fillgrove, K.L, Pakhomova, S, Schaab, M, Newcomer, M.E, Armstrong, R.N. | | 登録日 | 2007-03-20 | | 公開日 | 2007-07-17 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Structure and Mechanism of the Genomically Encoded Fosfomycin Resistance Protein, FosX, from Listeria monocytogenes.
Biochemistry, 46, 2007
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3D40
 | | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with diphosphate | | 分子名称: | DIPHOSPHATE, FomA protein | | 著者 | Pakhomova, S, Bartlett, S.G, Augustus, A, Kuzuyama, T, Newcomer, M.E. | | 登録日 | 2008-05-13 | | 公開日 | 2008-08-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Crystal Structure of Fosfomycin Resistance Kinase FomA from Streptomyces wedmorensis.
J.Biol.Chem., 283, 2008
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2P7K
 | | Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes (hexagonal form) | | 分子名称: | CITRIC ACID, Glyoxalase family protein | | 著者 | Fillgrove, K.L, Pakhomova, S, Schaab, M, Newcomer, M.E, Armstrong, R.N. | | 登録日 | 2007-03-20 | | 公開日 | 2007-07-17 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure and Mechanism of the Genomically Encoded Fosfomycin Resistance Protein, FosX, from Listeria monocytogenes.
Biochemistry, 46, 2007
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2P7Q
 | | Crystal structure of E126Q mutant of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and 1S,2S-dihydroxypropylphosphonic acid | | 分子名称: | Glyoxalase family protein, MANGANESE (II) ION, [(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC ACID | | 著者 | Fillgrove, K.L, Pakhomova, S, Schaab, M, Newcomer, M.E, Armstrong, R.N. | | 登録日 | 2007-03-20 | | 公開日 | 2007-07-17 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure and Mechanism of the Genomically Encoded Fosfomycin Resistance Protein, FosX, from Listeria monocytogenes.
Biochemistry, 46, 2007
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2P7O
 | | Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes (tetragonal form) | | 分子名称: | Glyoxalase family protein, MANGANESE (II) ION | | 著者 | Fillgrove, K.L, Pakhomova, S, Schaab, M, Newcomer, M.E, Armstrong, R.N. | | 登録日 | 2007-03-20 | | 公開日 | 2007-07-17 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Structure and Mechanism of the Genomically Encoded Fosfomycin Resistance Protein, FosX, from Listeria monocytogenes.
Biochemistry, 46, 2007
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