4X1F
Crystal structure of the hPXR-LBD in complex with the synthetic estrogen 17alpha-ethinylestradiol
Summary for 4X1F
| Entry DOI | 10.2210/pdb4x1f/pdb |
| Related | 4x1g |
| Descriptor | Nuclear receptor subfamily 1 group I member 2, Ethinyl estradiol, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total) |
| Functional Keywords | nuclear receptor, hormone receptor, pregnane x receptor, estrogen, gene regulation |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 36813.62 |
| Authors | Delfosse, V.,Huet, T.,Bourguet, W. (deposition date: 2014-11-24, release date: 2015-09-09, Last modification date: 2024-01-10) |
| Primary citation | Delfosse, V.,Dendele, B.,Huet, T.,Grimaldi, M.,Boulahtouf, A.,Gerbal-Chaloin, S.,Beucher, B.,Roecklin, D.,Muller, C.,Rahmani, R.,Cavailles, V.,Daujat-Chavanieu, M.,Vivat, V.,Pascussi, J.M.,Balaguer, P.,Bourguet, W. Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds. Nat Commun, 6:8089-8089, 2015 Cited by PubMed: 26333997DOI: 10.1038/ncomms9089 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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