7AXJ

Crystal structure of the hPXR-LBD in complex with estradiol and clotrimazole

Summary for 7AXJ

Entry DOI	10.2210/pdb7axj/pdb
Descriptor	Nuclear receptor subfamily 1 group I member 2, 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ESTRADIOL, ... (4 entities in total)
Functional Keywords	nuclear receptor hormone receptor pregnane x receptor, nuclear protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	37364.68
Authors	Delfosse, V.,Granell, M.,Blanc, P.,Bourguet, W. (deposition date: 2020-11-09, release date: 2021-01-13, Last modification date: 2024-01-31)
Primary citation	Delfosse, V.,Huet, T.,Harrus, D.,Granell, M.,Bourguet, M.,Gardia-Parege, C.,Chiavarina, B.,Grimaldi, M.,Le Mevel, S.,Blanc, P.,Huang, D.,Gruszczyk, J.,Demeneix, B.,Cianferani, S.,Fini, J.B.,Balaguer, P.,Bourguet, W. Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 33361153 DOI: 10.1073/pnas.2020551118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation