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3I4U
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BU of 3i4u by Molmil
Crystal Structure Analysis of a helicase associated domain
分子名称: ATP-dependent RNA helicase DHX8, BROMIDE ION, GLYCEROL
著者Kudlinzki, D, Ficner, R.
登録日2009-07-02
公開日2010-07-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22
Biol.Chem., 393, 2012
3E9L
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BU of 3e9l by Molmil
Crystal Structure of Human Prp8, Residues 1755-2016
分子名称: CHLORIDE ION, Pre-mRNA-processing-splicing factor 8, SODIUM ION
著者Pena, V, Rozov, A, Wahl, M.C.
登録日2008-08-22
公開日2008-10-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure and function of an RNase H domain at the heart of the spliceosome.
Embo J., 27, 2008
3E9O
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BU of 3e9o by Molmil
Crystal Structure of Yeast Prp8, Residues 1836-2092
分子名称: Pre-mRNA-splicing factor 8
著者Pena, V, Rozov, A, Wahl, M.C.
登録日2008-08-22
公開日2008-10-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure and function of an RNase H domain at the heart of the spliceosome.
Embo J., 27, 2008
3E9P
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BU of 3e9p by Molmil
Crystal Structure of Yeast Prp8, Residues 1827-2092
分子名称: Pre-mRNA-splicing factor 8
著者Pena, V, Rozov, A, Wahl, M.C.
登録日2008-08-22
公開日2008-10-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure and function of an RNase H domain at the heart of the spliceosome.
Embo J., 27, 2008
1LMV
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BU of 1lmv by Molmil
Solution structure of the unmodified U2 snRNA-intron branch site helix from S. cerevisiae
分子名称: 5'-R(*GP*GP*UP*GP*UP*AP*GP*UP*A)-3', 5'-R(*UP*AP*CP*UP*AP*AP*CP*AP*CP*C)-3'
著者Newby, M.I, Greenbaum, N.L.
登録日2002-05-02
公開日2002-11-27
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Sculpting of the Spliceosomal Branch Site Recognition Motif by a Conserved Pseudouridine
Nat.Struct.Biol., 9, 2002
4KIT
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BU of 4kit by Molmil
Crystal structure of human Brr2 in complex with the Prp8 Jab1/MPN domain
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, ...
著者Wahl, M.C, Wandersleben, T, Santos, K.F.
登録日2013-05-02
公開日2013-06-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.598 Å)
主引用文献Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8.
Science, 341, 2013
5EWR
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BU of 5ewr by Molmil
C merolae U4 snRNP protein Snu13
分子名称: Box C/D snoRNP and U4 snRNP component Snu13p
著者Garside, E.L, Black, C, Rader, S, MacMillan, A.M.
登録日2015-11-20
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Conserved structure of Snu13 from the highly reduced spliceosome of Cyanidioschyzon merolae.
Protein Sci., 25, 2016
5F5U
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BU of 5f5u by Molmil
Crystal structure of the Snu23-Prp38-MFAP1(217-258) complex of Chaetomium thermophilum
分子名称: Prp38, Putative uncharacterized protein, Zinc finger domain-containing protein
著者Ulrich, A.K.C, Seeger, M, Bartlick, N, Wahl, M.C.
登録日2015-12-04
公開日2016-10-19
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.748 Å)
主引用文献Scaffolding in the Spliceosome via Single alpha Helices.
Structure, 24, 2016
5F5V
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BU of 5f5v by Molmil
Crystal structure of the Snu23-Prp38-MFAP1(217-296) complex of Chaetomium thermophilum
分子名称: Prp38, Putative uncharacterized protein, Zinc finger domain-containing protein
著者Ulrich, A.K.C, Seeger, M, Bartlick, N, Wahl, M.C.
登録日2015-12-04
公開日2016-10-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Scaffolding in the Spliceosome via Single alpha Helices.
Structure, 24, 2016
5F5S
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BU of 5f5s by Molmil
Crystal structure of the Prp38-MFAP1 complex of Homo sapiens
分子名称: Microfibrillar-associated protein 1, Pre-mRNA-splicing factor 38A
著者Ulrich, A.K.C, Wahl, M.C.
登録日2015-12-04
公開日2016-10-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Scaffolding in the Spliceosome via Single alpha Helices.
Structure, 24, 2016
5F5T
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BU of 5f5t by Molmil
Crystal structure of the Prp38-MFAP1 complex of Chaetomium thermophilum
分子名称: Putative uncharacterized protein
著者Ulrich, A.K.C, Wahl, M.C.
登録日2015-12-04
公開日2016-10-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Scaffolding in the Spliceosome via Single alpha Helices.
Structure, 24, 2016
4BGD
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BU of 4bgd by Molmil
Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8
分子名称: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Nguyen, T.H.D, Li, J, Nagai, K.
登録日2013-03-25
公開日2013-05-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural Basis of Brr2-Prp8 Interactions and Implications for U5 Snrnp Biogenesis and the Spliceosome Active Site
Structure, 21, 2013
5DTU
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BU of 5dtu by Molmil
Crystal structure of the RNA-helicase Prp28 from Chaetomium thermophilum bound to ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Prp28
著者Tauchert, M.J, Ficner, R.
登録日2015-09-18
公開日2016-05-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.199 Å)
主引用文献Structural analysis of the spliceosomal RNA helicase Prp28 from the thermophilic eukaryote Chaetomium thermophilum.
Acta Crystallogr.,Sect.F, 72, 2016
1FHT
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BU of 1fht by Molmil
RNA-BINDING DOMAIN OF THE U1A SPLICEOSOMAL PROTEIN U1A117, NMR, 43 STRUCTURES
分子名称: U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A
著者Allain, F.H.-T, Gubser, C.C, Howe, P.W.A, Nagai, K, Neuhaus, D, Varani, G.
登録日1996-02-21
公開日1996-07-11
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding.
J.Mol.Biol., 257, 1996
5MFY
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BU of 5mfy by Molmil
RBM5 OCRE domain
分子名称: RNA-binding protein 5
著者Warner, L.R, Mourao, A, Soni, K, Sattler, M.
登録日2016-11-19
公開日2016-12-07
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulation.
Elife, 5, 2016
5DCA
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BU of 5dca by Molmil
Crystal structure of yeast full length Brr2 in complex with Prp8 Jab1 domain
分子名称: Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2
著者Absmeier, E, Wollenhaupt, J, Santos, K.F, Wahl, M.C.
登録日2015-08-23
公開日2015-12-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation.
Genes Dev., 29, 2015
5URM
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BU of 5urm by Molmil
Crystal structure of human BRR2 in complex with T-1206548
分子名称: 3-(5-{[(2R)-5-amino-2-cyclohexyl-7-oxo-2,3-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl]methyl}furan-2-yl)benzoic acid, U5 small nuclear ribonucleoprotein 200 kDa helicase
著者Klein, M.G, Tjhen, R, Qin, L.
登録日2017-02-11
公開日2017-07-19
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
J. Med. Chem., 60, 2017
5URJ
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BU of 5urj by Molmil
Crystal structure of human BRR2 in complex with T-3905516
分子名称: 6-benzyl-3-[(2R)-2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-1-benzopyran-7-yl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(3H,8H)-dione, GLYCEROL, U5 small nuclear ribonucleoprotein 200 kDa helicase
著者Klein, M.G, Tjhen, R, Qin, L.
登録日2017-02-10
公開日2017-07-19
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
J. Med. Chem., 60, 2017
5URK
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BU of 5urk by Molmil
Crystal structure of human BRR2 in complex with T-3935799
分子名称: 6-benzyl-3-[3-(benzyloxy)phenyl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(1H,3H)-dione, GLYCEROL, U5 small nuclear ribonucleoprotein 200 kDa helicase
著者Qin, L, Tjhen, R, Klein, M.G.
登録日2017-02-10
公開日2017-07-19
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
J. Med. Chem., 60, 2017
6FA9
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BU of 6fa9 by Molmil
CRYSTAL STRUCTURE OF THE DEAH-BOX HELICASE PRP2
分子名称: Putative mRNA splicing factor, SULFATE ION
著者Schmitt, A, Hamann, F, Neumann, P, Ficner, R.
登録日2017-12-15
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of the spliceosomal DEAH-box ATPase Prp2.
Acta Crystallogr D Struct Biol, 74, 2018
6FAC
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BU of 6fac by Molmil
CRYSTAL STRUCTURE OF THE DEAH-BOX HELICASE PRP2 IN COMPLEX WITH ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
著者Schmitt, A, Hamann, F, Neumann, P, Ficner, R.
登録日2017-12-15
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structure of the spliceosomal DEAH-box ATPase Prp2.
Acta Crystallogr D Struct Biol, 74, 2018
6FA5
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BU of 6fa5 by Molmil
CRYSTAL STRUCTURE OF THE DEAH-BOX HELICASE PRP2 IN COMPLEX WITH ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ...
著者Hamann, F, Schmitt, A, Neumann, P, Ficner, R.
登録日2017-12-15
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.303 Å)
主引用文献Crystal structure of the spliceosomal DEAH-box ATPase Prp2.
Acta Crystallogr D Struct Biol, 74, 2018
6FAA
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BU of 6faa by Molmil
CRYSTAL STRUCTURE OF THE DEAH-BOX HELICASE PRP2 IN COMPLEX WITH ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, ETHANOL, GLYCEROL, ...
著者Schmitt, A, Hamann, F, Neumann, P, Ficner, R.
登録日2017-12-15
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Crystal structure of the spliceosomal DEAH-box ATPase Prp2.
Acta Crystallogr D Struct Biol, 74, 2018
3HIB
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BU of 3hib by Molmil
Crystal structure of the second Sec63 domain of yeast Brr2
分子名称: Pre-mRNA-splicing helicase BRR2
著者Zhang, L, Xu, T, Zhao, R.
登録日2009-05-19
公開日2009-06-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2.
Nat.Struct.Mol.Biol., 16, 2009
8BC9
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Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 24
分子名称: 1,2-ETHANEDIOL, N-hydroxybenzenesulfonamide, Pre-mRNA-processing-splicing factor 8, ...
著者Vester, K, Loll, B, Wahl, M.C.
登録日2022-10-15
公開日2023-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2.
Acta Crystallogr D Struct Biol, 79, 2023

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